Results 81 to 90 of about 240,500 (234)
Frontiers in Physiology, 2012 Whether mouse models of chronic asthma can be used to investigate the relationship between airway inflammation/remodelling and airway hyper-responsiveness (AHR) is a vexed question.
Rakesh K. Kumar, Paul S. Foster
doaj +1 more source
Resolution of airway remodelling in a mouse model of chronic allergic asthma
, 2019 Asthma is associated with chronic airway inflammation and progressive airway remodelling. However, the dynamics of the development of these features and their spontaneous and pharmacological reversibility are still poorly understood.
Garn, Holger (Prof. Dr.) +1 more
core +1 more source
Three‐dimensional geometric morphometric analysis of diaphragmatic dome motion in COPD patients
The Anatomical Record, EarlyView.Abstract Diaphragmatic dysfunction is a hallmark of chronic obstructive pulmonary disease (COPD), especially in emphysema, where hyperinflation alters diaphragm geometry and impairs inspiratory mechanics. However, quantitative three‐dimensional (3D) assessments of diaphragmatic dome shape and motion across COPD phenotypes are limited.
José M. López‐Rey +5 more
wiley +1 more source
Airway disease phenotypes in animal models of cystic fibrosis
Respiratory Research, 2018 In humans, cystic fibrosis (CF) lung disease is characterised by chronic infection, inflammation, airway remodelling, and mucus obstruction. A lack of pulmonary manifestations in CF mouse models has hindered investigations of airway disease pathogenesis,
Alexandra McCarron +2 more
doaj +1 more source
The Anatomical Record, EarlyView.Abstract Sequence variations in fibroblast growth factor receptor 2 (FGFR2) are associated with craniosynostosis syndromes, disrupting craniofacial development, yet early mandibular alterations remain poorly characterized. This study examined Meckel's cartilage (MC) and mandibular morphology in mouse models of Apert (Fgfr2+/P253R) and Crouzon ...
Fred R. Foster +7 more
wiley +1 more source
, 2006 It is well known that the lungs of asthmatics show airway wall remodelling and that asthma exacerbations are linked to respiratory infections. There is some evidence that respiratory infections in early childhood may increase the risk of developing ...
Gualano, RC, Anderson, GP, Vlahos, R
core +1 more source
Arthritis &Rheumatology, EarlyView.Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib +8 more
wiley +1 more source
Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung
Pharmaceuticals, 2012 Therapies involving elevation of the endogenous suppressor cyclic AMP (cAMP) are currently used in the treatment of several chronic inflammatory disorders, including chronic obstructive pulmonary disease (COPD).
Martina Schmidt +2 more
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective Tissue‐specific biomarkers that are reliable and associated with clinical manifestations of idiopathic inflammatory myopathy (IIM) are lacking. The blood circulation in individuals serves as a central conduit, allowing communication between tissues and facilitating clearance and recycling of tissue‐derived proteins.
Yue‐Bei Luo +23 more
wiley +1 more source
Pharmacotherapy of asthma: regular treatment or on demand?
Therapeutic Advances in Respiratory Disease, 2009 Some studies have raised the question of the need for chronic controller therapy in mild persistent asthma as suggested by international guidelines. Although the Improving Asthma Control (IMPACT) and Beclomethasone plus Salbutamol (BEST) studies suggest ...
Paolo Montuschi +2 more
doaj +1 more source