The Anti-Sigma Factor MucA of Pseudomonas aeruginosa: Dramatic Differences of a mucA22 vs. a ΔmucA Mutant in Anaerobic Acidified Nitrite Sensitivity of Planktonic and Biofilm Bacteria in vitro and During Chronic Murine Lung Infection [PDF]
, 2019 Mucoid mucA22 Pseudomonas aeruginosa (PA) is an opportunistic lung pathogen of cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD) patients that is highly sensitive to acidified nitrite (A-NO2-).
Hassett, Daniel J. +14 more
core +2 more sources
An optimized perfusate for enhanced rat ex vivo lung perfusion and lung transplant models
Animal Models and Experimental Medicine, EarlyView.We explored a low‐cost and efficient perfusate composition for use in rat ex vivo lung perfusion (EVLP) and lung transplant models. This perfusate demonstrates better biocompatibility, likely due to a reduction in immune responses associated with high doses of xenogenic proteins, resulting in less lung injury posttransplantation.
Jie Zhang, Xuanlin Zhang, Jianxing He
wiley +1 more source
Non-local impact of distal airway constrictions on patterns of inhaled particle deposition [PDF]
arXivAirway constriction and blockage in obstructive lung diseases cause ventilation heterogeneity and create barriers to effective drug deposition. Established computational particle-deposition models have not accounted for these impacts of disease. We present a new particle-deposition model that calculates ventilation based on the resistance of each ...
arxiv
Investigation of the Methodology of Specific Airway Resistance Measurements in COPD. [PDF]
Int J Chron Obstruct Pulmon Dis, 2023 Dean J, Singh D.
europepmc +1 more source
The Effects of Ultrasonically-produced Aerosols on Airway Resistance in Man [PDF]
, 1968 Frederick W. Cheney, John M. Butler
openalex +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The rise in chronic lung diseases globally and the corresponding lag in drug discovery in this field highlights the need for In Vitro models closely mimicking In Vivo lung tissue. Efforts to date have largely focused on In Vitro coculture models, often neglecting the pulmonary vasculature's role in lung physiology and lacking perfusability. To
Sakshi Phogat +3 more
wiley +1 more source
Automatic Airway Segmentation in chest CT using Convolutional Neural Networks [PDF]
arXiv, 2018 Segmentation of the airway tree from chest computed tomography (CT) images is critical for quantitative assessment of airway diseases including bronchiectasis and chronic obstructive pulmonary disease (COPD). However, obtaining an accurate segmentation of airways from CT scans is difficult due to the high complexity of airway structures. Recently, deep
arxiv
Effect of aerosol propellants and surfactants on airway resistance [PDF]
, 1969 G. M. Sterling, John Batten
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