Results 41 to 50 of about 109,154 (297)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Orofacial-cervical alterations in individuals with upper airway resistance syndrome [PDF]

, 2015
INTRODUCTION: Studies that assess the upper airways in sleep-related breathing disorders have been performed only in patients with obstructive sleep apnea syndrome who seek medical attention.
Rogério Santos Silva, Lia Rita Azevedo Bittencourt, Sergio Tufik, Luis Carlos Gregório, Pedro Wey Barbosa de Oliveira, Luciano Lobato Gregorio   +5 more
core   +2 more sources

Risk of Narrow Upper Airway in Class II Children with Large Horizontal Maxillary Overjet Assessed By Acoustic Reflection: a Case-Control Study

eJournal of Oral Maxillofacial Research
Objectives: The aim of this case-control study was to examine upper airway by acoustic reflection in class II children with large horizontal maxillary overjet compared to children with neutral occlusion.
Camilla Hansen, Merete Bakke, Liselotte Sonnesen   +2 more
doaj   +1 more source

Measurement of airway function using invasive and non-invasive methodsin mild and severe models for allergic airway inflammation in mice

, 2014
In this study a direct comparison was made between non-invasive and non-ventilated unrestrained whole body plethysmography (Penh) (conscious animals) and the invasive ventilated lung resistance (RL) method (anaesthetized animals) in both mild and severe ...
Johan eGarssen, Kim eVerheijden, Frank A Redegeld, Verheijden, Kim A T, Paul A. J. Henricks, Garssen, Johan, Pharmacology, Gert Folkerts, Sub Immunopharmacology, Sub Airway in vivo Pharmacology, Kim A. T. Verheijden, Redegeld, Frank A., Henricks, Paul A J, Frank A. Redegeld, Paul eHenricks, Folkerts, Gert, Gert eFolkerts, UIPS - Utrecht Institute for Pharmaceutical Sciences, Johan Garssen   +18 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Effect of periodontal therapy on the oral microbiome and lung function: an intervention study

Frontiers in Cellular and Infection Microbiology
IntroductionThe oral cavity harbors over 700 bacterial species, and disruption of this balance can lead to periodontitis, which has been linked to systemic conditions including respiratory disease.MethodsIn this longitudinal clinical trial, 57 never ...
Anders Røsland, Anders Røsland, Hesham Amin, Stein Atle Lie, Andrei Malinovschi, Dagmar F. Bunæs, Dagmar F. Bunæs, Randi J. Bertelsen, Randi J. Bertelsen   +8 more
doaj   +1 more source

Characteristics and Outcomes of Male Participants in a Multicenter Longitudinal Australian Study Cohort

Arthritis Care &Research, EarlyView.
Objective The aim of this study was to determine the differences in demographic, serologic, and clinical characteristics between male and female patients with systemic sclerosis (SSc) in an Australian cohort. Methods This was a retrospective observational study using data from the Australian Scleroderma Cohort Study.
Emily Lin, Dylan Hansen, Laura Ross, Gene‐Siew Ngian, Susanna Proudman, Gabor Major, Maryam Tabesh, Mandana Nikpour, Jennifer Walker, Lauren Host, Nava Ferdowsi, Alannah Quinlivan, Wendy Stevens, Joanne Sahhar, Diane Apostolopoulos   +14 more
wiley   +1 more source

Acute Effect of Submaximal Exercise on Respiratory System Impedance in Healthy Adults

Journal of Functional Morphology and Kinesiology
Background: Previous studies have experimentally investigated and simulated the effects of dynamic hyperinflation on respiratory system resistance variables in populations with different respiratory diseases.
Thales Henrique do Carmo Furquim, Daniele Oliveira dos Santos, Jéssica Perossi, Fernanda Cristina Lima, Janne Marques Silveira, Ada Clarice Gastaldi   +5 more
doaj   +1 more source