Results 211 to 220 of about 1,534,638 (251)

cGMP Signaling in Arterioles Revealed by FRET‐Based Real‐Time Measurement in Mice In Vivo

open access: yesActa Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT cGMP evokes arteriolar vasorelaxation and is generated in smooth muscle by the soluble guanylyl cyclase (sGC) stimulated by endothelial NO. Phosphodiesterases (PDEs) degrade cGMP and may contribute in diameter regulation. We examined arteriolar cGMP levels in real‐time in vivo upon NO and acetylcholine (ACh) and effects of PDE inhibition ...
Lukas Thiele   +6 more
wiley   +1 more source

Honokiol regulates Acute respiratory distress syndrome (ARDS)‐associated pulmonary fibrosis via the miR‐19a‐3p/POSTN axis

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 21, Page 6329-6351, November 2026.
Abstract Background and Purpose Acute respiratory distress syndrome (ARDS) and subsequent pulmonary fibrosis are associated with high mortality and limited treatment options. Periostin (POSTN) is a profibrotic mediator predicted to be regulated by microRNA‐19a‐3p (miR‐19a‐3p), but the relevance of this axis in ARDS‐associated pulmonary fibrosis remains
Weilun Liu   +14 more
wiley   +1 more source

Matrix Metalloproteinase‐8 Deficiency Alters the Balance Between Viral Clearance and Immunopathology in H1N1 Infection

open access: yesThe FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Mmp‐8 deficiency during H1N1 influenza infection enhances Type I interferon responses, necroptosis‐associated signaling, and adaptive immunity, leading to lower lung viral burden and improved survival, but also amplifies inflammatory lung injury. ABSTRACT Matrix metalloproteinase‐8 (MMP‐8) regulates inflammatory responses, but its contributions to the ...
Xiaoyun Wang   +4 more
wiley   +1 more source

A-Kinase-Anchoring Protein Subtypes Differentially Regulate GPCR Signaling and Function in Human Airway Smooth Muscle. [PDF]

open access: yesAm J Respir Cell Mol Biol
Javed E   +8 more
europepmc   +1 more source

Electrospun Core–Shell Bioadhesive Nanofiber Sheets Enable Durable Pulmonary Air Leak Sealing Under Wet and Dynamic Conditions

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 40, 27 October 2026.
A core–shell electrospun nanofiber sheet provides strong adhesion and durable sealing on the wet and dynamic lung surface. The engineered fibrous architecture maintains airtight integrity and offers a potential alternative to fibrin sealants for pulmonary air leak management in thoracic surgery.
Tomohito Okubo   +10 more
wiley   +1 more source

Multiscale Coupling From Mastication to Retronasal Aroma Perception: The PG‐DTCFN Model and Multiphysics Simulation

open access: yesAdvanced Science, Volume 13, Issue 55, 5 October 2026.
Using grilled lamb skewers as a model system, this work builds a multiscale coupling framework from oral processing to retronasal aroma perception, reveals dual‐kinetic release patterns and Electroencephalogram‐characterized central encoding features, and proposes an interpretable physics‐guided deep learning model validated by multiphysics simulation,
Che Shen   +12 more
wiley   +1 more source

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