Bronchoconstriction: A Potential Missing Link in Airway Remodelling [PDF]
Open Biology, 2020 In asthma, progressive structural changes of the airway wall are collectively termed airway remodelling. Despite its deleterious effect on lung function, airway remodelling is incompletely understood.
Jin-Ah Park +2 more
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Artesunate ameliorates cigarette smoke-induced airway remodelling via PPAR-γ/TGF-β1/Smad2/3 signalling pathway [PDF]
Respiratory Research, 2021 Background Airway remodelling is the major pathological feature of chronic obstructive pulmonary disease (COPD), and leads to poorly reversible airway obstruction.
Kunming Pan, Juanjuan Lu, Yun Song
doaj +2 more sources
Exogenous Ang-(1-7) inhibits autophagy via HIF-1α/THBS1/BECN1 axis to alleviate chronic intermittent hypoxia-enhanced airway remodelling of asthma [PDF]
Cell Death Discovery, 2023 Obstructive sleep apnoea (OSA)-induced chronic intermittent hypoxia (CIH) has been considered a risk factor for severe asthma. Airway remodelling, which could be modulated by autophagy, plays a key role in severe asthma.
Jian Ping Zhou +10 more
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CT airway remodelling and chronic cough [PDF]
BMJ Open Respiratory Research, 2023 Rationale Structural airway changes related to chronic cough (CC) are described in the literature, but so far reported data are rare and non-conclusive. Furthermore, they derive mainly from cohorts with small sample sizes.
Jean Bourbeau +9 more
doaj +2 more sources
EV-associated non-coding RNAs in paediatric asthma airway remodelling: current mechanistic evidence and therapeutic perspectives [PDF]
Frontiers in PharmacologyPaediatric asthma is a chronic inflammatory airway disease that can cause airway swelling, excessive mucus secretion, and increased smooth muscle tone, leading to airway narrowing and respiratory distress.
Yaling Liu +5 more
doaj +2 more sources
The amount of hyaluronic acid and airway remodelling increase with the severity of inflammation in neutrophilic equine asthma [PDF]
BMC Veterinary ResearchBackground Equine asthma (EA) is a chronic lower airway inflammation that leads to structural and functional changes. Hyaluronic acid (HA) has crucial functions in the extracellular matrix homeostasis and inflammatory mediator activity.
Nina Höglund +8 more
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Neuroimmune Mechanisms in Equine Asthma: Primary Inflammatory Triggers, Neuroimmune Modulation and Chronic Airway Remodelling [PDF]
AnimalsEquine asthma is a chronic inflammatory disease of the lower respiratory tract, primarily associated with inhalation of organic dust, microbial particles and environmental aeroantigens.
Małgorzata Wierzbicka +2 more
doaj +2 more sources
Protective effects of ascorbic acid and calcitriol combination on airway remodelling in ovalbumin-induced chronic asthma [PDF]
Pharmaceutical Biology, 2020 Context Airway remodelling is one of the most refractory problems in asthma. According to the critical roles of oxidative stress and inflammation in airway remodelling, it is supposed that ascorbic acid and calcitriol have beneficial effects.
Farzaneh Kianian +5 more
doaj +2 more sources
MicroRNA-21 inhibition attenuates airway inflammation and remodelling by modulating the transforming growth factor β–Smad7 pathway [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims Current asthma therapies remain unsatisfactory for controlling airway remodelling in asthma. MicroRNA-21 is a key player in asthma pathogenesis, but the molecular mechanisms underlying its effects on airway remodelling are not completely ...
Jung Hur +4 more
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Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. [PDF]
PLoS ONE, 2013 Airway remodelling, including smooth muscle remodelling, is a primary cause of airflow limitation in asthma. Recent evidence links bronchoconstriction to airway remodelling in asthma. The mechanisms involved are poorly understood.
Tjitske A Oenema +5 more
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