Airway Remodelling in Asthma: From Benchside to Clinical Practice
Canadian Respiratory Journal, 2010 Airway remodelling refers to the structural changes that occur in both large and small airways relevant to miscellaneous diseases including asthma. In asthma, airway structural changes include subepithelial fibrosis, increased smooth muscle mass, gland ...
Céline Bergeron +2 more
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Quantification of collagen and proteoglycan deposition in a murine model of airway remodelling [PDF]
Respiratory Research, 2005 Background Sub-epithelial extracellular matrix deposition is a feature of asthmatic airway remodelling associated with severity of disease, decline in lung function and airway hyperresponsiveness.
Laurent Geoffrey J +3 more
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Compartmental and temporal dynamics of chronic inflammation and airway remodelling in a chronic asthma mouse model. [PDF]
PLoS ONE, 2014 BackgroundAllergic asthma is associated with chronic airway inflammation and progressive airway remodelling. However, the dynamics of the development of these features and their spontaneous and pharmacological reversibility are still poorly understood ...
Mohammed Alrifai +6 more
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The role of IgE-receptors in IgE-dependent airway smooth muscle cell remodelling. [PDF]
PLoS ONE, 2013 BACKGROUND: In allergic asthma, IgE increases airway remodelling but the mechanism is incompletely understood. Airway remodelling consists of two independent events increased cell numbers and enhanced extracellular matrix deposition, and the mechanism by
Michael Roth +5 more
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Airway Remodelling in Asthma and COPD: Findings, Similarities, and Differences Using Quantitative CT [PDF]
Pulmonary Medicine, 2012 Airway remodelling is a well-established feature in asthma and chronic obstructive lung disease (COPD), secondary to chronic airway inflammation. The structural changes found on pathological examination of remodelled airway wall have been shown to ...
Gaël Dournes, François Laurent
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Remodelling and Inflammation in Bronchial Asthma
European Journal of Inflammation, 2003 Chronic stable asthma is characterized by inflammation of the airway wall, with abnormal accumulation of basophils, eosinophils, lymphocytes, mast cells, macrophages, dendritic cells and myofibroblasts.
G. Riccioni +4 more
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Aspergillus fumigatus—Host Interactions Mediating Airway Wall Remodelling in Asthma [PDF]
Journal of Fungi, 2022 Asthma is a chronic heterogeneous respiratory condition that is mainly associated with sensitivity to airborne agents such as pollen, dust mite products and fungi.
Sara Namvar +3 more
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Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling. [PDF]
Eur Respir J, 2022 BACKGROUND: Airway smooth muscle (ASM) cells are fundamental to asthma pathogenesis, influencing bronchoconstriction, airway hyperresponsiveness and airway remodelling. The extracellular matrix (ECM) can influence tissue remodelling pathways; however, to
Ramis J +15 more
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Role of Inhaled Steroids in Vascular Airway Remodelling in Asthma and COPD [PDF]
International Journal of Endocrinology, 2012 In chronic obstructive airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), changes in bronchial microvasculature are present in response to inflammatory stimuli.
Alfredo Chetta, Dario Olivieri
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Airway remodelling in asthma and the epithelium: on the edge of a new era. [PDF]
Eur Respir JAsthma is a chronic, heterogeneous disease of the airways, often characterised by structural changes known collectively as airway remodelling. In response to environmental insults, including pathogens, allergens and pollutants, the epithelium can ...
Varricchi G +4 more
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