Results 71 to 80 of about 2,514 (185)

Isocitrate Dehydrogenase Mutations in Cancer: From Bench to Bedside Applications

MedComm, Volume 7, Issue 5, May 2026.
Mutant isocitrate dehydrogenase affects multiple cancer types. Alterations in IDH1 and IDH2 result in abnormal enzyme activity, leading to the overproduction of D‐2‐hydroxyglutarate (D‐2HG). This metabolite disrupts cellular metabolism and epigenetic regulation, driving cancer initiation, progression, and metastasis.
Yuhan Fang, Xiaoqing Wang, Kai Luo, Tikam Chand Dakal, He Bai, Caiming Xu, Guixin Zhang   +6 more
wiley   +1 more source

Sustained Belinostat‐Induced Metabolic Response and Tolerability in Heavily Pretreated Relapsed/Refractory Angioimmunoblastic T‐Cell Lymphoma: A Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Angioimmunoblastic T‐cell lymphoma (AITL), a rare and aggressive subtype of peripheral T‐cell lymphoma (PTCL), often demonstrates resistance to standard therapies. The optimal therapeutic approach for relapsed/refractory (R/R) AITL remains therefore uncertain and challenging, with an unmet need for effective treatment options.
Vassiliki Labropoulou, Evgenia Verigou, Eleni P. Kourea, Maria Liga, Dimitrios Tsokanas, Krisela‐Christina Valera, Alexandros Spyridonidis   +6 more
wiley   +1 more source

Erdheim‐Chester disease associated with myeloid neoplasm: Clinical features, molecular landscape, and treatment outcomes

HemaSphere, Volume 10, Issue 4, April 2026.
Abstract Erdheim‐Chester disease (ECD) is frequently associated with clonal hematopoiesis and myeloid neoplasms (MN), but clinical phenotype and response to kinase inhibitors (KI) in this setting remain unclear. We analyzed 67 patients with ECD associated with MN (ECD‐MN) from a French national cohort and assessed ECD treatment response, MN progression,
Ambroise Le Pogam, Matthias Papo, Pierre Hirsch, Fleur Cohen‐Aubart, Jean‐François Emile, François Delhommeau, Pierre Duffau, Jérôme Razanamahery, Florence Nguyen‐Khac, Christopher Nunes Gomes, Felicien Triboulet, Jeanne de La Rochefoucauld, Chloé McAvoy, Estibaliz Lazaro, Mehdi Hage‐Sleiman, Damien Roos‐Weil, François Chasset, Vincent Jachiet, Arsène Mekinian, Olivier Fain, Zahir Amoura, Jérôme Hadjadj, Julien Haroche   +22 more
wiley   +1 more source

Secondary cutaneous Epstein-Barr virus-associated diffuse large B-cell lymphoma in a patient with angioimmunoblastic T-cell lymphoma: a case report and review of literature

Diagnostic Pathology, 2012
Only a few cases of extranodal Epstein-Barr virus (EBV)-associated B-cell lymphomas arising from patients with angioimmunoblastic T-cell lymphoma (AITL) have been described.
Yang Qing-Xu, Pei Xiao-Juan, Tian Xiao-Ying, Li Yang, Li Zhi   +4 more
doaj   +1 more source

Advancing the Diagnosis of Non‐Hodgkin Lymphoma Through Next‐Generation Sequencing in Developing Countries: An Evaluation of Progress—A Narrative Review

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Non‐Hodgkin lymphoma (NHL) is the most prevalent hematological malignancy worldwide and accounts for approximately 3% of all cancer cases and fatalities. Next‐generation sequencing (NGS) has advanced molecular diagnosis and targeted treatment in developed countries.
Mohammadreza Saeidnia, Mehdi Shokri, Hassan Nourmohammadi, Safa Radmehr, Mashallah Babashahi, Mohamad Moradi, Maryam Karimian, Mohammad Panji, Elahe Motevaseli   +8 more
wiley   +1 more source

Clinicopathological implications of immunohistochemical expression of TBX21, CXCR3, GATA3, CCR4, and TCF1 in nodal follicular helper T-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified [PDF]

Journal of Pathology and Translational Medicine
Background The classification of nodal peripheral T-cell lymphoma (PTCL) has evolved according to histology, cell-of-origin, and genetic alterations. However, the comprehensive expression pattern of follicular helper T-cell (Tfh) markers, T-cell factor-1
Bogyeong Han, Sojung Lim, Jeemin Yim, Young Keun Song, Jiwon Koh, Sehui Kim, Cheol Lee, Young A Kim, Yoon Kyung Jeon   +8 more
doaj   +1 more source

A Murine Database of Structural Variants Identifies A Candidate Gene for a Spontaneous Murine Lymphoma Model

Advanced Science, Volume 13, Issue 17, 23 March 2026.
We analyzed long‐read genomic sequencing data obtained from 40 inbred mouse strains to produce a large database of structural variants. This dataset captures the major types of structural variants, which includes deletions, insertions, duplications, and inversions.
Wenlong Ren, Zhuoqing Fang, Egor Dolzhenko, Christopher T. Saunders, Zhuanfen Cheng, Victoria Popic, Gary Peltz   +6 more
wiley   +1 more source

Dupilumab and Systemic Hematologic Malignancies: Case Series and Literature Review

JEADV Clinical Practice, Volume 5, Issue 1, Page 171-175, March 2026.
ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting 15%–20% of children and 3%–10% of adults. An increased risk of systemic lymphomas – but not leukemias – has been reported in patients with AD. Dupilumab, a monoclonal IgG4 antibody targeting IL‐4 and IL‐13 signaling, is approved for moderate‐to‐severe AD and is ...
Nello Tommasino, Cataldo Patruno, Francesca di Vico, Maddalena Napolitano   +3 more
wiley   +1 more source

Development of a Novel Clinical Prognostic Model for Patients With Angioimmunoblastic T-Cell Lymphoma

Technology in Cancer Research & Treatment, 2020
In this study we aimed to identify a set of prognostic factors for angioimmunoblastic T-cell lymphoma (AITL) and establish a novel prognostic model. The clinical data of 64 AITL patients enrolled to the Fourth Hospital of Hebei Medical University (from ...
Chen Huang MD, Huichao Zhang MD, Yuhuan Gao BD, Lanping Diao BD, Lihong Liu PhD   +4 more
doaj   +1 more source

Epstein‐Barr Virus Infection at Single‐Cell Resolution

Journal of Medical Virology, Volume 98, Issue 2, February 2026.
ABSTRACT Epstein‐Barr virus (EBV) infection has been studied at single‐cell resolution for six decades and counting. Such investigations can reveal virus‐host interactions and their dependence on viral strain, cellular niche, infection program, immune response regulation, and time.
Elliott D. SoRelle
wiley   +1 more source