Results 41 to 50 of about 4,912,345 (213)

Akathisia Associated with the Use of Third-Generation Antipsychotics: Clinical Data Analysis and Management Strategies

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева
This article is a narrative review focused on the analysis of drug-induced akathisia associated with the use of antipsychotics exhibiting partial agonist activity at D2 receptors.
V. A. Bogacheva, D. V. Zakharov, V. А. Mikhailov   +2 more
doaj   +1 more source

Parasomnias and sleep‐related movement disorders induced by drugs in the adult population: a review about iatrogenic medication effects

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Parasomnias and sleep‐related movement disorders (SRMD) are major causes of sleep disorders and may be drug induced. The objective of this study was to conduct a systematic review of the literature to examine the association between drug use and the occurrence of parasomnias and SRMD.
Sylvain Dumont, Vanessa Bloch, Agnès Lillo‐Lelouet, Christine Le Beller, Pierre A. Geoffroy, Marc Veyrier   +5 more
wiley   +1 more source

Haloperidol for Hypoactive and Hyperactive Delirium in ICU Patients—A Post Hoc Bayesian Analysis of the AID‐ICU Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
ABSTRACT Background Delirium is clinically classified into hypoactive or hyperactive motoric subtypes, which may have different responses to treatment. We assessed heterogeneity in treatment effects according to baseline motoric subtype in the AID‐ICU trial, which randomised adult ICU patients with delirium to haloperidol versus placebo.
Nina C. Andersen‐Ranberg, Lone Musaeus Poulsen, Anders Perner, Johanna Hästbacka, Matthew Morgan, Giuseppe Citerio, Stine Estrup Damby, Camilla Bekker Mortensen, Marie Oxenbøll Collet, Sven‐Olaf Weber, Anne Sofie Andreasen, Morten Bestle, Bülent Uslu, Helle Scharling Pedersen, Louise Gramstrup Nielsen, Kjeld Damgaard, Troels Bek Jensen, Trine Sommer, Nilanjan Dey, Ole Mathiesen, Anders Granholm   +20 more
wiley   +1 more source

Is Aripiprazole an Effective Adjunct to Reduce Metabolic Adverse Effects Caused by Clozapine in Patients With Schizophrenia—A Systematic Review

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
Adjunctive aripiprazole may provide modest improvements in lipid parameters and body weight in clozapine‐treated patients with schizophrenia, but evidence for glucose and waist circumference outcomes remains limited. Larger, long‐term randomized controlled trials are needed.
Avtaar Singh, Soban Sadiq
wiley   +1 more source

Drug-Induced Movement Disorders and Its Associated Factors Among Patients Attending Treatment at Public Hospitals in Eastern Ethiopia

Neuropsychiatric Disease and Treatment, 2020
Tadesse Misgana,1 Niguse Yigzaw,2 Getachew Asfaw3 1Department of Psychiatry, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia; 2Department of Psychiatry, College of Medicine and Health Science, University of Gondar, Gondar ...
Misgana T, Yigzaw N, Asfaw G
doaj  

One patient with schizophrenia showed reduced drug-induced extrapyramidal symptoms as a result of an alternative regimen of treatment with paliperidone 3 and 6 mg every other day

SAGE Open Medical Case Reports, 2017
Background: Schizophrenia is a chronic disease that requires long-term management with antipsychotics. Antipsychotic drugs are given by tapering their dose, extending the dosing interval, and so on, as part of a treatment strategy to minimize the adverse
Hidenobu Suzuki, Hiroyuki Hibino, Yuichi Inoue, Hideo Matsumoto, Katsunaka Mikami   +4 more
doaj   +1 more source

The “GABAergic Brake” on the Spinal Defecation Reflex: A Proposed Neurobiological Model Explaining Clozapine‐ and Benzodiazepine‐Induced Gastrointestinal Hypomotility and Ogilvie's Syndrome

Neuropsychopharmacology Reports, Volume 46, Issue 3, September 2026.
Synergistic “Double Brake” Model on the Spinal Defecation Center in Clozapine‐Induced Constipation. Real‐world data shows BZDRs increase laxative risk in schizophrenia. Mitigating the central GABAergic brake via sedative optimization and maintaining gut microbiota homeostasis prevents fatal Ogilvie's syndrome.
Takahiko Nagamine
wiley   +1 more source

Deprescription of Psychotropics in Children and Adolescents: Systematic Review of Guidelines and Development of a Deprescribing Algorithm

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Background Psychotropics are increasingly prescribed in paediatrics despite limited evidence regarding their benefits and effectiveness. Although deprescribing approaches are established in adults, structured paediatric strategies remain poorly defined.
Paul‐Benoît Fargier, Mark Horowitz, Rodolphe Charles, Valérie Rousselon, Erik Fakra, Marie‐Noëlle Beyens, Marie‐Laure Laroche   +6 more
wiley   +1 more source

Diagnosis of drug induced liver injury using a lymphocyte blast transformation test based on whole blood culture [PDF]

, 1977
Twenty cases of suspected drug induced liver injury (16 cases of which satisfied the criteria for at least a query positive diagnosis as based on the Fourth Congress of "Drugs and the Liver" in Japan) were studied by the whole blood culture ...
Takata, Shinji
core   +1 more source

Xanomeline and Trospium Chloride: Mechanism of Action, Clinical, and Translational Science

Clinical and Translational Science, Volume 19, Issue 9, September 2026.
ABSTRACT Xanomeline‐trospium chloride (Cobenfy, formerly KarXT) is a first‐in‐class, oral central M1/M4 muscarinic receptor agonist approved for the treatment of schizophrenia in adults. Cobenfy represents a paradigm shift by avoiding direct dopamine D2 receptor blockade and thus significantly reduces the burden of metabolic, extrapyramidal, and ...
Samantha Avila, Ingrid L. Chen
wiley   +1 more source