Results 201 to 210 of about 80,331 (267)

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

Association of Sodium-Glucose Cotransporter 2 Inhibitors Treatment With Contrast-Induced Acute Kidney Injury in Older Adults With T2D and CKD: A Propensity Matched Analysis. [PDF]

J Diabetes
Ma J, Yang Q, Yang X, Liu K, Chen X, Liu F.   +5 more
europepmc   +1 more source

Effects of tempol on renal medullary tissue hypoxia in an ovine model of Gram‐negative septic acute kidney injury

Experimental Physiology, EarlyView.
Abstract Renal arterial infusion of tempol (RAT) at the onset of Gram‐negative sepsis can prevent sepsis‐induced medullary tissue hypoxia and acute kidney injury (AKI). However, it is not known whether treatment with tempol at a clinically relevant time point of sepsis is similarly effective. Thus, we examined whether tempol can reverse renal medullary
Rachel Peiris, Anton Trask‐Marino, Alemayehu Jufar, Ashenafi H. Betrie, Adam Southon, Sally G. Hood, Rinaldo Bellomo, Abraham H. Hulst, Clive N. May, Connie P. C. Ow, Yugeesh R. Lankadeva   +10 more
wiley   +1 more source

Long-term risks of major adverse cardiovascular events after acute kidney injury: a systematic review and meta-analysis. [PDF]

Clin Kidney J
Veltkamp DMJ, Zwank F, Groenestege WMT, Verhaar MC, van Solinge WW, Haitjema S, Vernooij RWM, Janse RJ.   +7 more
europepmc   +1 more source

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source

Proteomic signatures of renal recovery from acute kidney injury-a translational study in critically ill postoperative patients. [PDF]

Intensive Care Med Exp
von Groote T, Mertes MJ, Booke H, Sadjadi M, Strauß C, Schützenmeister K, Porschen C, Menke AF, de Grooth HJ, Forni LG, Meersch-Dini M, König S, Zarbock A.   +12 more
europepmc   +1 more source

Seven days of mixed‐method heat acclimation improved markers of cardiovascular and fluid‐regulatory strain during exercise‐heat stress

Experimental Physiology, EarlyView.
Abstract A mixed‐method heat acclimation (HA) protocol may optimise performance by supporting the training taper while promoting thermal adaptation; however, the impact on cardiovascular and fluid‐regulatory adjustments to protect health is unknown. Therefore, we examined the effects of a mixed‐method heat protocol on physiological responses, including
Daniel Snape, Barney Wainwright, Iain T. Parsons, Michael J. Stacey, David R. Woods, John O'Hara   +5 more
wiley   +1 more source

Contrast-Associated AKI in Hospitalized Adults With Sickle Cell Disease. [PDF]

Kidney Int Rep
Azoyan L, Lombardi Y, Bartolucci P, Lionnet F, Chantalat Auger C, Le Jeune S, Affo L, Arlet JB, Haymann JP, Leblanc J, Steichen O.   +10 more
europepmc   +1 more source

Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials

Experimental Physiology, EarlyView.
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler, Pedro Rojas‐Morales, Roman‐Ulrich Müller   +2 more
wiley   +1 more source