Results 221 to 230 of about 972,716 (314)

STOML2 promotes hepatocellular carcinoma cell proliferation, invasion and migration by activating the PI3K/AKT signaling pathway (Review). [PDF]

Oncol Lett
Li M, Chen J.
europepmc   +1 more source

Functional specificity of Akt isoforms in cancer progression

, 2011
Anne-Marie Fortier, Éric Asselin, Monique Cadrin   +2 more
openalex   +1 more source

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Amphiregulin attenuates sepsis-induced myocardial dysfunction by maintaining the localization of connexin43. [PDF]

Inflamm Regen
Chen M, Takamori S, Isayama K, Wang Y, Matsunaga S, Narahara S, Honsho M, Murata M, Kinugawa S, Abe K, Akahoshi T.   +10 more
europepmc   +1 more source

Possible Involvement of Akt Activity in Endothelial Dysfunction in Type 2 Diabetic Mice

, 2008
Yasuhiro Takenouchi, Tsuneo Kobayashi, Takayuki Matsumoto, Katsuo Kamata   +3 more
openalex   +2 more sources

VE‐Cadherin–Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension‐Sensitive Intermediate State

Advanced Science, EarlyView.
This study investigates how endothelial monolayers balance cohesion and plasticity during mechanical stimulation. In HUVECs, shear stress induces a tension‐sensitive intermediate state in which junctional VE‐cadherin and actomyosin relaxation levels coordinate actin/integrin remodeling. This rapid, reversible state strengthens cell junctions, preserves
Jonas Franz, Maria Odenthal‐Schnittler, Jan Philip Kipcke, Jochen Seebach, Zahra Labbaf, Franziska Merten, Vesna Bojovic, Muna Taha, Johannes A. Eble, Erez Raz, Milos Galic, Hans Schnittler   +11 more
wiley   +1 more source

Ghrelin Inhibit the Synovial Cells Apoptosis and Aoutphagy Via ADORA2B/ PI3K/Akt/mTOR Axis

Jian Huang
openalex   +1 more source

Carbamylated Erythropoietin Regulates Immune Responses and Promotes Long-Term Kidney Allograft Survival Through Activation of PI3K/AKT Signaling

, 2019
Ning Na, Daqiang Zhao, Jinhua Zhang, Shicong Yang, Dielai Xie, Jiaqing Wu, Bin Miao, Heng Li, Yingxun Luo, Zuofu Tang, Wensheng Zhang   +10 more
openalex   +1 more source

Neuroprotective Effects of Time‐Restricted Feeding Combined With Different Protein Sources in MPTP‐Induced Parkinson's Disease Mice Model and Its Modulatory Impact on Gut Microbiota Metabolism

Advanced Science, EarlyView.
Time‐restricted feeding (TRF) exerts protein‐dependent neuroprotective effects in an MPTP‐induced Parkinson's disease model. In casein‐fed mice, TRF improves gut barrier integrity and reduces neuroinflammation, possibly via modulation of Allobaculum and BCAAs.
Ting Li, Jian Wu, Sheng‐Yang Zhou, Ming‐An Li, Li‐Ping Zhao, Ao Wang, Yi‐Zhi Song, Wen‐Yan Huang, Lu‐Lu Tan, Chen‐Meng Qiao, Wei‐Jiang Zhao, Chun Cui, Yan‐Qin Shen   +12 more
wiley   +1 more source