Results 261 to 270 of about 532,309 (312)

PI3K/Akt Signaling as a Potential Therapeutic Target for Reducing Inflammation and Corneal Stromal Injury in Microsporidial Stromal Keratitis. [PDF]

Invest Ophthalmol Vis Sci
Wei Y, Xu X, Peng Y, Pang J, Chen Q, Peng B, Shen S, Liang Q.   +7 more
europepmc   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

Advanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang, Xiuying Jiang, Xi Sun, Hao Chen, Jianjun Jin, Xin'e Shi   +5 more
wiley   +1 more source

GRB2 Promotes Sorafenib Resistance in Hepatocellular Carcinoma Cells Under Hypoxia by Activating the PI3K/AKT Signaling Pathway. [PDF]

J Hepatocell Carcinoma
He J, Kong Y, Wang Y, Fang Q, Wu H, Du K, Luo Y, Tan J, Yin H, Lin H, Li M.   +10 more
europepmc   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Mechanism Through Which Antioxidant Polysaccharide from <i>Tetrastigma hemsleyanum</i> Protects Against DSS-Induced Ulcerative Colitis: Insights from Multi-Omics. [PDF]

Molecules
Zhang L, Xu W, Liao X, Yuan G, Jin C, Xiao H, Liu H, Jin Z, Deng Y, Liu Y.   +9 more
europepmc   +1 more source

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

G protein-coupled receptor 1 participating in the mechanism of mediating gestational diabetes mellitus by phosphorylating the AKT pathway

Open Life Sciences
Zhu Yanbin, Huang Shufeng, Chai Dan, Liang Lei   +3 more
doaj   +1 more source

Effects of <i>TRIB3</i> gene overexpression and interference on lipid metabolism in mammary epithelial cells of yaks. [PDF]

Front Vet Sci
Zheng J, Lei F, Liu S, Zhao Y, Zhang Z, Dong B, Feng H, Jing H.   +7 more
europepmc   +1 more source

Combination of ivermectin and metformin promotes autophagy in MCF‑7 cells by inhibiting phosphorylation of the PI3K/AKT/mTOR pathway. [PDF]

Oncol Rep
Feng H, He L, Umar T, Wang H, Gao Y, Chen G, Sun P, Yin L, Zhao W, Lu H, Deng G, Qiu C.   +11 more
europepmc   +1 more source

Nuclear translocation of mitochondrial ferredoxin reductase is regulated by AKT-mediated phosphorylation. [PDF]

Biochem J
Nakajima KI, Mohibi S, Chen X, Zhang J.
europepmc   +1 more source