Results 91 to 100 of about 16,704,778 (257)
Organ responses with daratumumab therapy in previously treated AL amyloidosis.
Blood Advances, 2020 Immunoglobulin light chain amyloidosis (AL amyloidosis) involves deposition of abnormally folded light chains into a wide range of tissues causing organ dysfunction, including in the heart and kidney.
A. Chung +8 more
semanticscholar +1 more source
Blood ScienceAmyloid light chain (AL) amyloidosis is a rare plasma cell dyscrasia with dismal prognosis. This study aims to investigate the T-cell immune checkpoint expression patterns in systemic AL amyloidosis and its relationship with clinicobiological traits.
Jinghua Wang +7 more
doaj +1 more source
Gastroparesis in a Patient with Gastric AL Amyloidosis
Case Reports in Gastroenterology, 2018 Systemic amyloidosis is a group of complex disorders characterized by the extracellular deposition of nonbranching fibrils in various tissues, ultimately leading to a variety of clinical presentations including isolated or multiorgan dysfunction. Amyloid
Matthew Hoscheit +2 more
doaj +1 more source
Epidemiological, clinical and laboratorial profile of renal amyloidosis: a 12-year retrospective study of 37 cases [PDF]
Journal of Nephropathology, 2015 Background: Renal amyloidosis is one of the main differential diagnoses in the investigation of nephrotic proteinuria in adults, especially elderly patients.
Elissa Oliveira da Fonseca +3 more
doaj +1 more source
The Relation Between α-Helical Conformation And Amyloidogenicity [PDF]
, 2017 Amyloid fibrils are stable aggregates of misfolded proteins and polypeptides that are insoluble and resistant to protease activity. Abnormal formation of amyloid fibrils in vivo may lead to neurodegenerative disorders and other systemic amyloidosis such as Alzheimer's, Parkinson's, and atherosclerosis.
arxiv +1 more source
Nature Communications, 2019 Amyloid fibrils derived from antibody light chains are key pathogenic agents in systemic AL amyloidosis. They can be deposited in multiple organs but cardiac amyloid is the major risk factor of mortality.
L. Radamaker +8 more
semanticscholar +1 more source
Annals of Internal Medicine: Clinical CasesLight chain (AL) amyloidosis involves deposition of monoclonal immunoglobulin light chain-derived amyloid fibrils, whereas ATTR amyloidosis involves deposition of insoluble antiparallel beta-pleated protein within tissues, leading to organ-specific ...
Robert A. Churchill, Andrew Rosenbaum
doaj +1 more source
AL Amyloidosis with Renal Involvement [PDF]
Kidney and Blood Pressure Research, 2007 Primary (AL amyloidosis) is a systemic disease characterized by an amyloid deposition process in many organs, with unsatisfactory survival of patients. The monoclonal light chains form the fibrils that deposit and accumulate in tissues. Renal involvement is very frequent in AL amyloidosis and could lead to development of nephrotic syndrome followed by ...
openaire +3 more sources
Non-native beta-sheet formation: insights into protein amyloidosis [PDF]
arXiv, 2002 Protein amyloidosis is a cytopathological process characterized by the formation of highly beta-sheet-rich fibrils. How this process occurs and how to prevent/treat the associated diseases are not completely understood. Here, we carry out a theoretical investigation of sequence-independent beta-sheet formation, based on recent findings regarding the ...
arxiv
F1000Research, 2018 Immunoglobulin (Ig) light chain (AL) amyloidosis is a clonal plasma cell disorder characterized by misfolded Ig light chain deposition in vital organs of the body, resulting in proteotoxicity and organ dysfunction.
Talha Badar +2 more
doaj +1 more source