Results 251 to 260 of about 54,210 (294)
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Immunotherapy in AL Amyloidosis
Current Treatment Options in Oncology, 2022Light-chain amyloidosis is a rare disorder where a small clone of plasma cells is producing excess toxic light chains that deposit in various organs and cause dysfunction. Cardiac involvement is a major determinant of survival and rapid reduction of light chain is critical for recovery of organ function and overall survival. Immunotherapy targeting the
Yifei, Zhang, Raymond L, Comenzo
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New England Journal of Medicine
AL Amyloidosis A 58-year-old man presented with a 2-year history of eyelid lesions and several months of weight loss and fatigue. Scattered periorbital petechiae and purpura were noted, as well as coalescing, waxy papules on the eyelids.
Miguel Mansilla Polo +1 more
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AL Amyloidosis A 58-year-old man presented with a 2-year history of eyelid lesions and several months of weight loss and fatigue. Scattered periorbital petechiae and purpura were noted, as well as coalescing, waxy papules on the eyelids.
Miguel Mansilla Polo +1 more
+9 more sources
Once AL amyloidosis: not always AL amyloidosis
Amyloid, 2018Amyloid cardiomyopathy could be related to AL amyloidosis, wild-type transthyretin amyloidosis (ATTRwt) or hereditary amyloidosis (ATTRm).
Tulip Jhaveri +5 more
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The Lancet, 2014
A 62-year-old man came to our outpatient clinic with purpura on his eyelids. 7 months before, periocular purpura appeared after a minimal trauma. These lesions did not resolve for months. He also reported fatigue over the previous 6 months. On examination pinch purpura between smooth waxy papules were found (fi gure).
Barbara C, Böckle, Norbert T, Sepp
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A 62-year-old man came to our outpatient clinic with purpura on his eyelids. 7 months before, periocular purpura appeared after a minimal trauma. These lesions did not resolve for months. He also reported fatigue over the previous 6 months. On examination pinch purpura between smooth waxy papules were found (fi gure).
Barbara C, Böckle, Norbert T, Sepp
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Macroglossia – not always AL amyloidosis
Amyloid, 2010Abstract Abstract 5007 Introduction: Amyloidosis is characterized by extracellular deposition of abnormal insoluble fibrillar proteins. The two most frequent systemic amyloidoses are the light-chain (AL amyloidosis) and familial transthyretin (ATTR) forms.
Andrew J, Cowan +6 more
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La Revue de medecine interne, 2015
AL amyloidosis belongs to the group of conformational diseases. It is the most common type of amyloidosis with an estimated 500 new cases per year in France. It is due to a small and usually indolent plasma cell clone which synthesizes an unstable, misfolded monoclonal immunoglobulin light chain that is prone to aggregate and form amyloid fibrils.
A, Jaccard +3 more
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AL amyloidosis belongs to the group of conformational diseases. It is the most common type of amyloidosis with an estimated 500 new cases per year in France. It is due to a small and usually indolent plasma cell clone which synthesizes an unstable, misfolded monoclonal immunoglobulin light chain that is prone to aggregate and form amyloid fibrils.
A, Jaccard +3 more
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Diagnosis and Treatment of AL Amyloidosis
Drugs, 2023Systemic light chain (AL) amyloidosis is caused by an usually small B cell clone that produces a toxic light chain forming amyloid deposits in tissue. The heart and kidney are the major organs affected, but all others, with the exception of the CNS, can be involved. The disease is rapidly progressive, and it is still diagnosed late.
Giovanni Palladini, Paolo Milani
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Archives of Internal Medicine, 1984
[ill]myloidosis is considered by many to be a rare disease. In a retrospective review by Alexanian al in this issue,130 cases of amyloidosis were [ill]gnosed during a 15-year span. Because symptoms [ill]re present for 20 months before diagnosis, the [ill]hors point out the need for better identification [ill]d earlier diagnosis.
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[ill]myloidosis is considered by many to be a rare disease. In a retrospective review by Alexanian al in this issue,130 cases of amyloidosis were [ill]gnosed during a 15-year span. Because symptoms [ill]re present for 20 months before diagnosis, the [ill]hors point out the need for better identification [ill]d earlier diagnosis.
openaire +2 more sources