Results 1 to 10 of about 4,867,269 (191)

Cutaneous light chain amyloidosis with multiple myeloma: A concise review

Hematology/Oncology and Stem Cell Therapy, 2019
Objective/Background: Cutaneous immunoglobulin (Ig) amyloid light-chain (AL) amyloidosis associated with overt multiple myeloma (MM) is rare and optimal treatment is not well defined.
Mirela Andrei, Jen Chin Wang
doaj   +2 more sources

A stepwise data interpretation process for renal amyloidosis typing by LMD-MS

BMC Nephrology, 2022
Backgrounds Systemic amyloidosis is classified according to the deposited amyloid fibril protein (AFP), which determines its best therapeutic scheme. The most common type of AFP found are immunoglobulin light chains.
Ming Ke, Xin Li, Lin Wang, Shuling Yue, Beibei Zhao   +4 more
doaj   +1 more source

Chronic myopathy due to immunoglobulin light chain amyloidosis [PDF]

Molecular Genetics and Metabolism, 2013
Amyloid myopathy associated with a plasma cell dyscrasia is a rare cause of muscle hypertrophy. It can be a challenging diagnosis, since pathological findings are often elusive. In addition, the mechanism by which immunoglobulin light-chain deposition stimulates muscle overgrowth remains poorly understood. We present a 53-year old female with a 10-year
Manoli, Irini, Kwan, Justin Y, Wang, Qian, Rushing, Elisabeth J, Tsokos, Maria, Arai, Andrew E, Burch, Warner M, Dispenzieri, Angela, McPherron, Alexandra C, Gahl, William A   +9 more
openaire   +4 more sources

Activity of pomalidomide in patients with immunoglobulin light-chain amyloidosis [PDF]

Blood, 2012
Abstract Immunoglobulin light-chain (AL) amyloidosis is a rare, incurable plasma cell disorder. Its therapy has benefited immensely from the expanding drug armamentarium available for multiple myeloma. Pomalidomide in combination with weekly dexamethasone (Pom/dex) is active among patients with relapsed myeloma.
Angela, Dispenzieri, Francis, Buadi, Kristina, Laumann, Betsy, LaPlant, Suzanne R, Hayman, Shaji K, Kumar, David, Dingli, Steven R, Zeldenrust, Joseph R, Mikhael, Robert, Hall, S Vincent, Rajkumar, Craig, Reeder, Rafael, Fonseca, P Lief, Bergsagel, A Keith, Stewart, Vivek, Roy, Thomas E, Witzig, John A, Lust, Stephen J, Russell, Morie A, Gertz, Martha Q, Lacy   +20 more
openaire   +2 more sources

Light-chain amyloidosis with dysphagia as the main symptom: a case report

Journal of Medical Case Reports
Background Immunoglobulin light-chain amyloidosis is a relatively rare condition with a worldwide incidence of 5.1–12.8 cases per million person-years (Baker, 2022).
Maomao Ai, Tao Lin, Ruoyu Guo, Haiyao Zheng, Haiyan Deng, Feng Yu   +5 more
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Cardiac Amyloidosis: Clinical Features, Pathogenesis, Diagnosis, and Treatment [PDF]

Türk Patoloji Dergisi
Cardiac amyloidosis is a type of amyloidosis that deserves special attention as organ involvement significantly worsens the prognosis. Cardiac amyloidosis can be grouped under three main headings: immunoglobulin light chain (AL) amyloidosis that is ...
Asuman ARGON, Deniz NART, Funda YILMAZ BARBET   +2 more
doaj   +1 more source

Germ line origin and somatic mutations determine the target tissues in systemic AL-amyloidosis. [PDF]

PLoS ONE, 2007
BACKGROUND: Amyloid is insoluble aggregated proteins deposited in the extra cellular space. About 25 different proteins are known to form amyloid in vivo and are associated with severe diseases such as Alzheimer's disease, prion diseases and type-2 ...
Stina Enqvist, Knut Sletten, Fred J Stevens, Ulf Hellman, Per Westermark   +4 more
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Clinical Outcome of Immunoglobulin Light Chain Amyloidosis Affecting the Kidney [PDF]

Blood, 2008
Abstract Introduction: The kidney is affected by immunoglobulin light chain amyloidosis (AL) in more than 50% of patients who present with the disease, but long-term predictors for and outcomes after renal replacement therapy have not been well described in this patient group Patients: 145 patients with AL who participated
Morie A, Gertz, Nelson, Leung, Martha Q, Lacy, Angela, Dispenzieri, Steven R, Zeldenrust, Suzanne R, Hayman, Francis K, Buadi, David, Dingli, Philip R, Greipp, Shaji K, Kumar, John A, Lust, S Vincent, Rajkumar, Stephen J, Russell, Thomas E, Witzig   +13 more
openaire   +2 more sources

Systemic Immunoglobulin Light Chain Amyloidosis Presenting as Painful Penile Ulcers

Annals of Internal Medicine: Clinical Cases, 2022
Immunoglobulin light chain (AL) amyloidosis is a systemic form of amyloidosis that commonly affects the heart, kidney, liver, and nervous system. Penile involvement in AL amyloidosis is rare and thus often not considered in the differential diagnosis for
Crystal Lihong Yan, Fireneh N. Beshah, Karen Eliahu, James E. Hoffman   +3 more
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Diagnosing Smoldering Multiple Myeloma and Light Chain Amyloidosis in the Setting of Severe Transthyretin Amyloid Cardiomyopathy and Extracardiac Sarcoidosis

Annals of Internal Medicine: Clinical Cases
Light chain (AL) amyloidosis involves deposition of monoclonal immunoglobulin light chain-derived amyloid fibrils, whereas ATTR amyloidosis involves deposition of insoluble antiparallel beta-pleated protein within tissues, leading to organ-specific ...
Robert A. Churchill, Andrew Rosenbaum
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