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Immunoglobulin light chain amyloidosis [PDF]
Memo - Magazine of European Medical Oncology, 2021 SummaryImmunoglobulin light chain (AL) amyloidosis is a rare and underdiagnosed life-threatening systemic disease, primarily caused by insoluble depositions of misfolded monoclonal light chains. The monoclonal light chain paraprotein originates from a small clonal B‑cell or a clonal plasma cell population.
Hermine Agis
exaly +2 more sources
Immunoglobulin light chain amyloidosis and the kidney [PDF]
Kidney International, 2002 Immunoglobulin light chain amyloidosis and the kidney. Amyloidosis (AL) is a common cause of nephrotic syndrome in nondiabetic, nonhypertensive adults. All adult patients with nephrotic syndrome should have immunofixation of serum and urine as a screen.
Gertz, Morie A. +2 more
openaire +4 more sources
Immunoglobulin light chain amyloidosis diagnosis and treatment algorithm 2021 [PDF]
Blood Cancer Journal, 2021 Immunoglobulin light chain amyloidosis (AL) commonly presents with nephrotic range proteinuria, heart failure with preserved ejection fraction, nondiabetic peripheral neuropathy, unexplained hepatomegaly or diarrhea, and should be considered in patients ...
M. Hasib Sidiqi, Morie A. Gertz
doaj +2 more sources
Immunoglobulin Light Chain Amyloidosis: Diagnosis and Risk Assessment. [PDF]
J Natl Compr Canc Netw, 2023 Immunoglobulin light chain (AL) amyloidosis is a clonal plasma cell disorder with multiple clinical presentations. The diagnosis of AL amyloidosis requires a high index of suspicion, making a delay in diagnosis common, which contributes to the high early mortality seen in this disease.
Zanwar S, Gertz MA, Muchtar E.
europepmc +3 more sources
Localized Lymph Node Light Chain Amyloidosis [PDF]
Case Reports in Hematology, 2015 Immunoglobulin-derived light chain amyloidosis can occasionally be associated with localized disease. We present a patient with localized lymph node light chain amyloidosis without an underlying monoclonal protein or lymphoproliferative disorder and ...
Binod Dhakal +3 more
doaj +2 more sources
Exploiting endogenous and therapy-induced apoptotic vulnerabilities in immunoglobulin light chain amyloidosis with BH3 mimetics [PDF]
Nature Communications, 2022 Immunoglobulin light chain amyloidosis is a lethal hematologic disorder driven by clonal plasma cells producing abnormal light chains that damage healthy tissues. Fraser et al.
Cameron S. Fraser +14 more
doaj +2 more sources
PLoS ONE, 2020 Immunoglobulin light chain amyloidosis is the most common form of systemic amyloidosis. AL amyloidosis is caused by a misfolded light chain produced by a clonal population of plasma cells.
Elaine C Chen +9 more
doaj +2 more sources
Daratumumab for Immunoglobulin Light Chain Amyloidosis [PDF]
Oncology & Haematology, 2021 Immunoglobulin light chain (AL) amyloidosis is characterized by small, indolent plasma cell clones that uniformly demonstrate high expression of CD38 surface molecule and produce toxic, free light chains.
Theodorakakou, Foteini +2 more
core +4 more sources
Clinical characteristics and prognosis of immunoglobulin light chain amyloidosis patients. [PDF]
Front Med (Lausanne)Objective To analyze the prognostic factors associated with overall survival (OS) in patients diagnosed with immunoglobulin light chain (AL) amyloidosis, with the goal of improving risk stratification and patient management.
Song L +9 more
europepmc +3 more sources
Suggestive Diagnostic Process in a Case of Multiple Myeloma with Gastrointestinal Immunoglobulin Light-Chain Amyloidosis Accompanied by Protein-Losing Enteropathy [PDF]
Case Reports in Gastrointestinal Medicine, 2021 Multiple myeloma is a type of plasma cell neoplasm that produces monoclonal immunoglobulin. Multiple myeloma is known to cause immunoglobulin light-chain (AL) amyloidosis, which frequently involves the kidney and heart.
Katsuya Endo +15 more
doaj +2 more sources