Results 41 to 50 of about 37,394 (238)

Amyloidosis of the gastrointestinal tract: a 13-year, single-center, referral experience

Haematologica, 2013
Amyloidosis of the gastrointestinal tract, with biopsy-proven disease, is rare. We reviewed a series of patients who presented with biopsy-proven gastrointestinal amyloidosis and report their clinical characteristics, treatments, and survival.
Andrew J. Cowan, Martha Skinner, David C. Seldin, John L. Berk, David R. Lichtenstein, Carl J. O'Hara, Gheorghe Doros, Vaishali Sanchorawala   +7 more
doaj   +1 more source

Light‐chain amyloid myopathy isolated to skeletal muscles: A case report

Clinical Case Reports, 2020
Isolated amyloidosis, especially of amyloid light‐chain type, is an infrequent disease. Systemic chemotherapy for light‐chain amyloidosis isolated to skeletal muscles plays a key role to reduce clonal plasma cells producing aberrant immunoglobulin.
Toshihiro Matsukawa, Katsuki Eguchi, Ichizo Nishino, Kohei Okada, Kazuo Oshimi, Takuto Miyagishima   +5 more
doaj   +1 more source

Amyloid light-chain deposition in a schwannoma

Interdisciplinary Neurosurgery, 2021
Systemic amyloid light-chain amyloidosis is a protein misfolding disorder characterized by extracellular deposition of amyloid fibrils derived from abnormal clonal immunoglobulin light chains in various organ systems.
Megan M. Jack, Brandon W. Smith, Christopher J. Klein, Taxiarchis Kourelis, Andrew L. Folpe, Robert J. Spinner, Ellen D. McPhail   +6 more
doaj   +1 more source

Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties [PDF]

, 2002
The X-ray structure of an immunoglobulin light-chain dimer isolated from the urine as a 'Bence-Jones protein' from a patient with multiple myeloma and amyloidosis (Sea) was determined at 1.94 Angstrom resolution and refined to R and R-free factors of 0 ...
Bourne, P. C., DeWitt, C. R., Edmundson, A. B., Fan, Z. C., Guddat, L. W., Moomaw, C. R., Ramsland, P. A., Shan, L., Shultz, B. B., Slaughter, C. A., Terzyan, S. S.   +10 more
core   +2 more sources

FOCUSED REVIEW ON NUTRITIONAL STATUS OF PATIENTS WITH IMMUNOGLOBULIN LIGHT CHAIN AMYLOIDOSIS

medRxiv, 2021
Background: Immunoglobulin light chain (AL) amyloidosis is a complex disease marked by a poor clinical portrait and prognosis generally leading to organ dysfunction and shortened survival.
S. Grigoletti, P. Zuchinali, É. Lemieux-Blanchard, S. Béchard, B. Lemieux, P. A. Ribeiro, F. Tournoux   +6 more
semanticscholar   +1 more source

Immunoglobulin light chain amyloidosis and the kidney [PDF]

Kidney International, 2002
Immunoglobulin light chain amyloidosis and the kidney. Amyloidosis (AL) is a common cause of nephrotic syndrome in nondiabetic, nonhypertensive adults. All adult patients with nephrotic syndrome should have immunofixation of serum and urine as a screen.
Gertz, Morie A., Lacy, Martha Q., Dispenzieri, Angela   +2 more
openaire   +2 more sources

Biomarkers in Immunoglobulin Light Chain Amyloidosis

Klinicka Onkologie, 2017
Immunoglobulin light chain amyloidosis (AL amyloidosis - ALA) is a monoclonal gammopathy characterized by presence of aberrant plasma cells producing amyloidogenic immunoglobulin light chains. This leads to formation of amyloid fibrils in various organs and tissues, mainly in heart and kidney, and causes their dysfunction.
Kufova, Z., Sevcikova, T., Growkova, K., Vojta, P., Filipova, J., Adam, Z., Pour, L., Penka, M., Rysava, R., Nemec, P., Brozova, L., Vychytilova, P., Jurczyszyn, Artur, Grosicki, S., Barchnicka, A., Hajduch, M., Simicek, M., Hajek, R.   +17 more
openaire   +4 more sources

Natural history and outcome in systemic AA amyloidosis [PDF]

, 2007
BACKGROUND:Deposition of amyloid fibrils derived from circulating acute-phase reactant serum amyloid A protein (SAA) causes systemic AA amyloidosis, a serious complication of many chronic inflammatory disorders.
Gallimore, JR, Gilbertson, JA, Gillmore, JD, Goodman, HJB, Hawkins, PN, Lachmann, HJ, Sabin, CA   +6 more
core   +1 more source

C-src Enriched Serum Microvesicles Are Generated in Malignant Plasma Cell Dyscrasia [PDF]

, 2013
Plasma cell dyscrasias are immunosecretory disorders that can lead to hematological malignancies such as Multiple Myeloma (MM). MM accounts for 15% of all hematologic cancers, and those diagnosed with MM typically become severely ill and have a low life
Andrea, Zendrini, Caimi, Luigi, DI NOTO, Giuseppe, Paolini, Lucia, Radeghieri, Annalisa, Ricotta, Doris   +5 more
core   +8 more sources

Clinical diagnosis and typing of systemic amyloidosis in subcutaneous fat aspirates by mass spectrometry-based proteomics

Haematologica, 2014
Examination of abdominal subcutaneous fat aspirates is a practical, sensitive and specific method for the diagnosis of systemic amyloidosis. Here we describe the development and implementation of a clinical assay using mass spectrometry-based proteomics ...
Julie A. Vrana, Jason D. Theis, Surendra Dasari, Oana M. Mereuta, Angela Dispenzieri, Steven R. Zeldenrust, Morie A. Gertz, Paul J. Kurtin, Karen L. Grogg, Ahmet Dogan   +9 more
doaj   +1 more source