Results 321 to 330 of about 17,175,483 (375)

The Evolution of Functional Amyloids and Their Impact on Host–Microbe Interactions

Advanced Science, Volume 12, Issue 38, October 13, 2025.
This review describes functional amyloids and highlights the importance of structural repetition and molecular mimicry that distinguish the amyloid fold. The authors describe how amyloid can be the last universal common ancestor of protein folds. The authors also discuss how microbes utilize functional amyloids and how the structural characteristics of
Divya Kolli, Saroj K. Rout, Roland Riek, Matthew R. Chapman   +3 more
wiley   +1 more source

Genome Sequencing Uncovers Additional Findings in Phelan‐McDermid Syndrome

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Volume 198, Issue 7, Page 126-134, October 2025.
ABSTRACT Phelan‐McDermid syndrome (PMS) is a genetic condition caused by deletions of chromosome 22q13.3 or pathogenic variants in the SHANK3 gene. Neurologic features typically include intellectual disability, autism spectrum disorder, hypotonia, and absent speech, though there is considerable variability even among individuals with the same molecular
Rachel Gore Moses, Morgan Similuk, Alexandra Hehn, Rylee Duncan, Margaret Pekar, Eliza Gordon‐Lipkin, Maria T. Acosta, Deena Zeltser, Nadjalisse Reynolds‐Lallement, Latha Soorya, Mustafa Sahin, Tess Levy, Alexander Kolevzon, Joseph D. Buxbaum, Elizabeth Berry‐Kravis, Craig M. Powell, Jonathan A. Bernstein, Mari Tokita, Bryce A. Seifert, Rajarshi Ghosh, Magdalena A. Walkiewicz, Audrey Thurm   +21 more
wiley   +1 more source

Febrile neutropenia in patients with Duffy-null-associated neutrophil counts and multiple myeloma or AL amyloidosis. [PDF]

Blood Adv
Abdallah M, Arters F, Patel J, Edwards C, Lerner A, Petrocca F, Dockerty M, Fuller B, Godfrey A, Staron A, Sanchorawala V, Sloan JM, Bertrand K, Szalat R.   +13 more
europepmc   +1 more source

SGLT‐2 inhibitors for cardiac amyloidosis: Hype or hope?

European Journal of Clinical Investigation, Volume 55, Issue 11, November 2025.
Flavio Tangianu, Eleonora Nicolini, Francesco Dentali, Aldo Bonaventura   +3 more
wiley   +1 more source

Decoding adipose–brain crosstalk: Distinct lipid cargo in human adipose‐derived extracellular vesicles modulates amyloid aggregation in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Obesity is a major modifiable risk factor for Alzheimer's disease (AD), but the mechanistic link between peripheral metabolic dysfunction and AD progression remains unclear. Adipose‐derived extracellular vesicles (EVs) may penetrate the brain and alter lipid homeostasis, contributing to neurodegeneration.
Li Yang, Michael Chan, Jianting Sheng, Shaohua Qi, Bill Chan, Dharti Shantaram, Xilal Y. Rima, Eduardo Reategui, Xianlin Han, Willa A. Hsueh, Stephen T. C. Wong   +10 more
wiley   +1 more source

Predicting Structural Consequences of Antibody Light Chain N-Glycosylation in AL Amyloidosis. [PDF]

Pharmaceuticals (Basel)
Morgan GJ, Yung Z, Spencer BH, Sanchorawala V, Prokaeva T.   +4 more
europepmc   +1 more source

White matter hyperintensities precede other biomarkers in GRN frontotemporal dementia

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Increased white matter hyperintensities (WMHs) have been reported in genetic frontotemporal dementia (FTD) in small studies, but the sequence of WMH abnormalities relative to other biomarkers is unclear. METHODS Using a large dataset (n = 763 GENFI2 participants), we measured WMHs and examined them across genetic FTD variants and ...
Mahdie Soltaninejad, Mahsa Dadar, D. Louis Collins, Reza Rajabli, Vikram Venkatraghavan, Arabella Bouzigues, Lucy L. Russell, Phoebe H. Foster, Eve Ferry‐Bolder, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Raquel Sanchez‐Valle, Robert Laforce, Caroline Graff, Daniela Galimberti, Rik Vandenberghe, Alexandre de Mendonça, Pietro Tiraboschi, Isabel Santana, Alexander Gerhard, Johannes Levin, Benedetta Nacmias, Markus Otto, Maxime Bertoux, Thibaud Lebouvier, Chris R. Butler, Isabelle Le Ber, Elizabeth Finger, Maria Carmela Tartaglia, Mario Masellis, James B. Rowe, Matthis Synofzik, Fermin Moreno, Barbara Borroni, Jonathan D. Rohrer, Yasser Iturria‐Medina, Simon Ducharme, GENFI Consortium   +38 more
wiley   +1 more source

Glymphatic and meningeal lymphatic dysfunction in Alzheimer's disease: Mechanisms and therapeutic perspectives

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid‐beta (Aβ) deposition and tau pathology. Although disease‐modifying therapies, such as anti‐Aβ monoclonal antibodies, have been approved, their clinical efficacy remains modest and accompanied by substantial safety concerns. The glymphatic system, which is a brain‐
Jiangwei Ding, Chengbin Zhao, Xiaoyan Hao, Hongliang Jiao   +3 more
wiley   +1 more source

Spontaneous Hepatic Hemorrhage as a Rare Presentation of Amyloid Light Chain (AL) Amyloidosis: A Case Report. [PDF]

Cureus
Srivastava M.
europepmc   +1 more source

Alzheimer's disease diagnostic progression is associated with cerebrovascular disease and neuroinflammation in adults with Down syndrome

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Despite having few vascular risk factors, people with Down syndrome (DS) have MRI evidence of cerebrovascular disease (CVD) and neuroinflammation that worsens with Alzheimer's disease (AD) severity. We investigated whether markers of CVD and inflammation are associated with AD‐related diagnostic progression in people with DS ...
Natalie C. Edwards, Patrick J. Lao, Mohamad J. Alshikho, Olivia M. Ericsson, Batool Rizvi, Melissa E. Petersen, Sid O'Bryant, Lisi Flores‐Aguilar, Sabrina Simoes, Mark Mapstone, Dana L. Tudorascu, Shorena Janelidze, Oskar Hansson, Benjamin L. Handen, Bradley T. Christian, Joseph H. Lee, Florence Lai, H Diana Rosas, Shahid Zaman, Ira T. Lott, Michael A. Yassa, Alzheimer's Biomarkers Consortium–Down Syndrome (ABC‐DS) Investigators, José Gutierrez, Donna M. Wilcock, Elizabeth Head, Adam M. Brickman   +25 more
wiley   +1 more source