Results 61 to 70 of about 54,210 (294)

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

Kidney-limited AL amyloidosis: a case report and review of the literature

Journal of Community Hospital Internal Medicine Perspectives, 2021
Amyloidosis involves the deposition of abnormal proteins in various tissues and results in progressive organ dysfunction, commonly affecting multiple organs.
Sara Velayati, Alexander Belkin, Gurwinder Sidhu Kumar, Zubin J Tharayil, Neeru Kumar, Samir Patel   +5 more
doaj   +1 more source

Perspectives in treatment of AL amyloidosis [PDF]

British Journal of Haematology, 2007
SummaryLight chain (AL) amyloidosis is the most frequently diagnosed form of systemic amyloid in the western world. The historically poor prognosis of AL amyloidosis appears to be improving with currently reported median survival of c. 40 months compared to 13 months in the early 1990s when low‐dose oral melphalan was the mainstay of treatment ...
Ashutosh D, Wechalekar, Philip N, Hawkins, Julian D, Gillmore   +2 more
openaire   +2 more sources

Primary bladder amyloidosis as a cause of haematuria

, 2018
We report the case of a 46-year-old man who initially presented with macroscopic haematuria. Although initially concerning for a malignancy in the bladder, histology demonstrated a primary bladder amyloidosis that has remained stable for 6 years since ...
Nesbitt, AL, Khan, M, Lokan, J, Hoag, N
core   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

Treatment patterns and outcomes in light chain amyloidosis: An institutional registry of amyloidosis report in Argentina.

PLoS ONE, 2022
Light chain (AL) amyloidosis is a form of systemic amyloidosis, causing organ dysfunction, mainly affecting the heart and kidney. Patient-tailored and risk-adapted decision making is critical in AL amyloidosis management.
Maria Lourdes Posadas-Martinez, María Adela Aguirre, Erika Brulc, Maria Soledad Saez, Patricia Sorroche, Gerardo Machnicki, Mariana Fernandez, Elsa Mercedes Nucifora   +7 more
doaj   +1 more source

Resting State fMRI Reveals Diminished Functional Connectivity in a Mouse Model of Amyloidosis [PDF]

, 2013
Introduction: Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer’s disease (AD). AD is a complex disorder, characterised by several pathological features. The problem
Rafael Delgado Y Palacios, Christian Bigot, Van Der Linden, Anne-Marie, Bigot, Christian, Van der Linden, Annemie, Rafael Delgado y Palacios (498616), Verhoye, Marleen, Disha Shah, Annemie Van der Linden, Christian Bigot (498617), Dany V D'Souza, Shah, Disha, Disha Shah (498613), Annemie Van der Linden (2227165), Elisabeth Jonckers, D'Souza, Dany V., Greetje Vanhoutte, Jonckers, Elisabeth, Jelle Praet (498614), Delgado y Palacios, Rafael, Greetje Vanhoutte (498615), Marleen Verhoye, Praet, Jelle, Marleen Verhoye (95635), Vanhoutte, Greetje, Jelle Praet, Elisabeth Jonckers (353117), Dany V. D’Souza (498618)   +27 more
core   +1 more source

Molecular Mobility of N‐Acetylgalactosamine‐Modified Cyclodextrins on a Polyrotaxane for Highly Efficient Liver Targeting of Antibody Chimeras and Genome‐Editing Ribonucleoproteins

Advanced Science, EarlyView.
Monovalent N‐acetylgalactosamine (GalNAc)‐modified polyrotaxane enables efficient liver targeting by utilizing ligand mobility. The sliding and rotating cyclic components i.e., cyclodextrin in the polyrotaxane dynamically cluster GalNAc moieties, thereby mimicking trivalent interactions with asialoglycoprotein receptors.
Toru Taharabaru, Keiichi Motoyama, Yuting Wen, Zhongxing Zhang, Xuehao Tian, Jun Li, Taishi Higashi   +6 more
wiley   +1 more source

Beyond Survival in AL amyloidosis: Identifying and Satisfying Patients’ Needs

Hemato, 2022
The survivorship needs of patients with light-chain (AL) amyloidosis are complex, as is the diagnosis and treatment itself. Early diagnosis is critical in improving patient outcomes; however, given the nonspecific nature of the symptoms, most patients ...
Hamza Hassan, Vaishali Sanchorawala
doaj   +1 more source

Upfront CyBorD in AL amyloidosis [PDF]

Blood, 2015
In this issue of Blood , [Palladini et al][1] report on the outcome of a large series of 230 patients with systemic immunoglobulin (Ig) amyloid light chain (AL) amyloidosis treated frontline with cyclophosphamide, bortezomib, and dexamethasone (CyBorD) at 2 referral centers.[1][2] ![Figure][3]
M Teresa, Cibeira, Joan, Bladé
openaire   +2 more sources