Results 81 to 90 of about 16,704,778 (257)
Identification of Causal Relationship between Amyloid-beta Accumulation and Alzheimer's Disease Progression via Counterfactual Inference [PDF]
arXiv, 2023 Alzheimer's disease (AD) is a neurodegenerative disorder that is beginning with amyloidosis, followed by neuronal loss and deterioration in structure, function, and cognition. The accumulation of amyloid-beta in the brain, measured through 18F-florbetapir (AV45) positron emission tomography (PET) imaging, has been widely used for early diagnosis of AD.
arxiv
A Case of Systemic AL Amyloidosis Diagnosed by Screening Colonoscopy
Case Reports in Gastrointestinal Medicine, 2022 Amyloidosis encompasses several diseases associated with deposition of low-molecular-weight proteins in an abnormal configuration. In light-chain amyloidosis (AL), monoclonal free lambda (λ) or kappa (κ) light chains are the amyloid proteins involved and
Lynna Alnimer +6 more
doaj +1 more source
Solvent and mutation effects on the nucleation of amyloid $β$-protein folding [PDF]
, 2005 Experimental evidence suggests that the folding and aggregation of the amyloid $\beta$-protein (A$\beta$) into oligomers is a key pathogenetic event in Alzheimer's disease (AD). Inhibiting the pathologic folding and oligomerization of A$\beta$ could be effective in the prevention and treatment of AD.
arxiv +1 more source
Blood Advances, 2020 Despite achieving a hematologic complete response after treatment, many patients with AL amyloidosis do not attain recovery of organ function and/or experience hematologic relapse.
Andrew Staron +5 more
semanticscholar +1 more source
Improving management of AL amyloidosis
Annals of the Academy of Medicine, Singapore, 2023 In this issue of the Annals, Tan et al. on behalf of Singapore Myeloma Study Group presented the consensus guidelines on light chain (AL) amyloidosis.1 This is an encouraging effort as AL amyloidosis is a rare disease, with diagnostic and therapeutic challenges.
Yuh Shan, Lee, Jeffrey, Huang
openaire +2 more sources
Aspects of structural landscape of human islet amyloid polypeptide [PDF]
, 2014 The human islet amyloid polypeptide (hIAPP) co-operates with insulin to maintain glycemic balance. It also constitutes the amyloid plaques that aggregate in the pancreas of type-II diabetic patients. We have performed extensive in silico investigations to analyse the structural landscape of monomeric hIAPP, which is presumed to be intrinsically ...
arxiv +1 more source
Optimization of $Al/AlO_x/Al$-Layer Systems for Josephson Junctions from a Microstructure Point of View [PDF]
Journal of Applied Physics 125, 165301 (2019), 2019 $Al/AlO_x/Al$-layer systems are frequently used for Josephson junction-based superconducting devices. Although much work has been devoted to the optimization of the superconducting properties of these devices, systematic studies on influence of deposition conditions combined with structural analyses on the nanoscale are rare up to now.
arxiv +1 more source
Peritoneal amyloidosis with myopathy in primary systemic (AL) amyloidosis [PDF]
BMJ Case Reports, 2017 We present an unusual case of primary systemic amyloidosis presenting with myopathy and peritoneal amyloid deposition. Peritoneal amyloid is a rare disease with few published cases.1 An 85-year-old man was referred to rheumatology with walking difficulties and elevation of serum creatine kinase (CK).
Ali Al-Adhami +2 more
openaire +2 more sources
A Generalizable Deep Learning System for Cardiac MRI [PDF]
arXiv, 2023 Cardiac MRI allows for a comprehensive assessment of myocardial structure, function, and tissue characteristics. Here we describe a foundational vision system for cardiac MRI, capable of representing the breadth of human cardiovascular disease and health.
arxiv
Blood, 2019 Bortezomib is a standard therapy in AL amyloidosis (AL), but little is known about response duration. A difference in involved amyloidogenic and uninvolved serum free light chains (dFLC) less than 10mg/L (low-dFLC response) post-treatment predicts ...
R. Manwani +12 more
semanticscholar +1 more source