Results 131 to 140 of about 897,077 (404)

Genetic correlation between circulating metabolites and chalazion: a two-sample Mendelian randomization study

open access: yesFrontiers in Molecular Biosciences
Background: Lipid metabolism disorders were observationally associated with chalazion, but the causality of the related circulating metabolites on chalazion remained unknown.
Xin Zhang   +6 more
doaj   +1 more source

Germinant receptor diversity and germination responses of four strains of the Bacillus cereus group [PDF]

open access: yes, 2010
Four strains of the Bacillus cereus group were compared for their germinant receptor composition and spore germination capacity. Phylogenetic analysis of the germinant receptor encoding operons of the enterotoxic strains B.
Abee, T.   +3 more
core   +2 more sources

Diverse taxa of cyanobacteria produce beta-N-methylamino-L-alanine, a neurotoxic amino acid.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2005
Cyanobacteria can generate molecules hazardous to human health, but production of the known cyanotoxins is taxonomically sporadic. For example, members of a few genera produce hepatotoxic microcystins, whereas production of hepatotoxic nodularins appears
P. Cox   +9 more
semanticscholar   +1 more source

Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations

open access: yesAdvanced Functional Materials, EarlyView.
Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou   +2 more
wiley   +1 more source

Study on synthesis of alanine derivative and corrosion inhibition on carbon steel

open access: yesGongye shui chuli
Alanine hydrochloride was prepared from alanine, then its derivative was synthesized by amidation. The structure of the synthesized product was characterized by infrared and 1H nuclear magnetic resonance.
TIAN Huijuan   +3 more
doaj   +1 more source

Metabolomics Reveal d-Alanine:d-Alanine Ligase As the Target of d-Cycloserine in Mycobacterium tuberculosis

open access: yesACS Medicinal Chemistry Letters, 2013
Stable isotope-mass spectrometry (MS)-based metabolomic profiling is a powerful technique for following changes in specific metabolite pool sizes and metabolic flux under various experimental conditions in a test organism or cell type.
G. Prosser, L. P. S. de Carvalho
semanticscholar   +1 more source

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

open access: yesAdvanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang   +9 more
wiley   +1 more source

Determination of Imidazole Dipeptides and Related Amino Acids in Natural Seafoods by Liquid Chromatography–Tandem Mass Spectrometry Using a Pre-Column Derivatization Reagent

open access: yesFoods
Imidazole dipeptides (IDPs) and taurine (Tau) have several health benefits and are known to be contained in natural seafoods. However, their levels vary widely in different natural seafoods, making their simultaneous determination desirable.
Mayu Onozato   +5 more
doaj   +1 more source

Local Order in the Unfolded State: Conformational Biases and Nearest Neighbor Interactions

open access: yesBiomolecules, 2014
The discovery of Intrinsically Disordered Proteins, which contain significant levels of disorder yet perform complex biologically functions, as well as unwanted aggregation, has motivated numerous experimental and theoretical studies aimed at describing ...
Siobhan Toal   +1 more
doaj   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

open access: yesAdvanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim   +8 more
wiley   +1 more source

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