Results 211 to 220 of about 803,336 (334)

Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver–Brain Axis

Advanced Science, EarlyView.
Arsenic in realgar induces CNS toxicity through direct and indirect effects: it activates ZBTB7A in astrocytes, which in turn inhibits glycolysis and impairs mice's learning, memory, and exploration; it also suppresses OTC in the liver to block the ornithine cycle, leading to blood ornithine accumulation that crosses into the frontal lobe and further ...
Ping Ye, Zhen Li, Huanyong Fu, Shuai Wang, Xingang Cui, Chengbo Song, Chao Ma, Hong Jiang   +7 more
wiley   +1 more source

Increased 1-deoxysphingolipids caused by an altered plasma alanine to serine ratio are associated with metabolic dysfunction-associated steatotic liver disease (MASLD). [PDF]

Metabolomics
Wipfli F, A Lone M, von Eckardstein A, Verrijken A, Francque S, Weyler J, Van Gaal L, Staels B, Hornemann T.   +8 more
europepmc   +1 more source

Correction for Girard et al., “Uptake of l -Alanine and Its Distinct Roles in the Bioenergetics of Trypanosoma cruzi ” [PDF]

, 2018
Richard M. B. M. Girard, Marcell Crispim, Mayke Bezerra Alencar, Ariel Mariano Silber   +3 more
openalex   +1 more source

Epigenetic Targeting of Senescent Cells Prevents the Deleterious Effects of Obstructive Sleep Apnea on Growing Skeleton

Advanced Science, EarlyView.
Chronic intermittent hypoxia induces premature senescence of osteoprogenitor cells in long bone metaphysis via HIF1α‐mediated EZH2‐H3k27me3 downregulation, leading to impaired bone growth. Restoration of H3K27me3 level via UTX inhibition rescues osteogenesis and growth impairment in young mice.
Xiaonan Liu, Peilin Zhang, Zhongyi Su, Yong Feng, Zhenger Zhou, Sa Pang, Yicheng Wang, Jiacheng Hu   +7 more
wiley   +1 more source

A novel low -cost and sensitive sensor for the voltammetric nano detection of linezolid antibiotic in real samples using carbon paste electrode modified with calcium oxide nanoparticle combined with electropolymerized D-alanine. [PDF]

BMC Chem
Khodari M, Hassan NZ, Mohamed AE, Rashed MN.   +3 more
europepmc   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

DFT calculations and theory do not support enantiospecificity in NMR J-coupling constants. [PDF]

Nat Commun
Perras FA, Zwanziger JW, Rossini AJ.
europepmc   +1 more source

One-Pot Synthesis of Alanine from Glycerol Without Additional H2 Over a Rutile-Supported Ru Catalyst

Jiachen Li, Zhenchen Tang, Huaizhou Yang, D Gerlach, Petra Rudolf, Hero J. Heeres, Paolo P. Pescarmona   +6 more
openalex   +1 more source

Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration

Advanced Science, EarlyView.
Through a genetic screen, PKN2 and MOB4 are identified as two proteins regulating the healing of an epithelial model wound. PKN2 promotes collective cell migration by maintaining the cohesion of cell monolayers from their lateral junctions, whereas MOB4 restrains collective cell migration and provides a lamellipodial cue for front‐rear polarity in ...
Artem I. Fokin, Yueying Lin, Dmitry Y. Guschin, Hsiang‐Ying Chen, John James, Jie Yan, Pascal Silberzan, Alexis M. Gautreau   +7 more
wiley   +1 more source

AlphaFold-Guided Discovery of an Overlapping MYC/Miz-1 Interface Enables Peptidomimetic Disruption of MYC/MAX. [PDF]

ChemMedChem
Ellenbroek BD, Tirtosentono ASS, Pomplun SJ.   +2 more
europepmc   +1 more source