Results 231 to 240 of about 897,077 (404)

S‐ketamine Alleviates Neuroinflammation and Attenuates Lipopolysaccharide‐Induced Depression Via Targeting SIRT2

Advanced Science, EarlyView.
S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin, Xiaoxuan Zhou, Mingqi Li, Cong Zhang, Haojiang Zhai, Haohong Li, Hongshuang Wang, Xiaohui Wang   +7 more
wiley   +1 more source

Accurate temperature dependence of structure factors of L-alanine and taurine for quantum crystallography. [PDF]

IUCrJ
Hayashi M, Nishioka T, Kasai H, Nishibori E.   +3 more
europepmc   +1 more source

THE IONIZATION OF dl-ALANINE FROM TWENTY TO FORTY-FIVE DEGREES

, 1933
Leslie F. Nims, Paul K. Smith
openalex   +1 more source

Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation

Advanced Science, EarlyView.
Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu, Tong Ji, Zhichao Ye, Jianing Yan, Chao Wang, Jiachen Chen, Ziyang Jin, Yongji Zhu, Xiujun Cai, Yifan Wang   +9 more
wiley   +1 more source

Glycine receptor activation promotes pancreatic islet cell proliferation via the PI3K/mTORC1/p70S6K pathway. [PDF]

JCI Insight
Zhang Z, Ye WW, Piro AL, Wang DS, Untereiner A, Lyons SA, Bhattacharjee A, Singh I, Beaudry JL, Orser BA, Dai FF, Wheeler MB.   +11 more
europepmc   +1 more source

RELATIVE AMOUNT OF HEPATIC GLYCOGEN DEPOSITED BY GLUCOSE, GLYCINE, AND dl-ALANINE

, 1940
Eaton M. MacKay, Arne N. Wick, Herbert O. Carne   +2 more
openalex   +1 more source

Carnosine and anserine homeostasis in skeletal muscle and heart is controlled by β‐alanine transamination

Journal of Physiology, 2016
L. Blancquaert, S. Baba, S. Kwiatkowski, J. Stautemas, Sanne Stegen, S. Barbaresi, Weiliang Chung, A. Boakye, J. Hoetker, A. Bhatnagar, J. Delanghe, B. Vanheel, M. Veiga-da-Cunha, W. Derave, I. Everaert   +14 more
semanticscholar   +1 more source

Inhibition of Ferroptosis Delays Aging and Extends Healthspan Across Multiple Species

Advanced Science, EarlyView.
This study identifies ferroptosis as a key driver of cellular senescence, with its inhibition delaying aging and extending healthspan across species. During senescence, ferroptosis worsens, increasing oxidative stress and lipid peroxidation, which accelerate aging.
Hai‐Jun Fu, Xing‐Yue Zhou, Da‐Lian Qin, Qan Qiao, Qiao‐Zhi Wang, Shi‐Ying Li, Yun‐Fei Zhu, Ya‐Ping Li, Jiang‐Min Zhou, Hui Cai, Fei‐Hong Huang, Lu Yu, Long Wang, An‐Guo Wu, Jian‐Ming Wu, Xiao‐Gang Zhou   +15 more
wiley   +1 more source

Targeting the Exonic Circular <i>OGT</i> RNA/O-GlcNAc Transferase/Forkhead Box C1 Axis Inhibits Asparagine- and Alanine-Mediated Ferroptosis Repression in Neuroblastoma Progression. [PDF]

Research (Wash D C)
Li Q, Cheng Y, Yang C, Tian M, Wang X, Li D, Li X, Qu J, Zhou S, Zheng L, Tong Q.   +10 more
europepmc   +1 more source

THE FREE ENERGIES OF FORMATION OF AQUEOUS d-ALANINE, l-ASPARTIC ACID, AND d-GLUTAMIC ACID

, 1933
Henry Borsook, Hugh M. Huffman
openalex   +1 more source