Results 211 to 220 of about 109,106 (257)

Alanine dehydrogenases in mycobacteria

Journal of Microbiology, 2019
Since NAD(H)-dependent L-alanine dehydrogenase (EC 1.1.4.1; Ald) was identified as one of the major antigens present in culture filtrates of Mycobacterium tuberculosis, many studies on the enzyme have been conducted. Ald catalyzes the reversible conversion of pyruvate to alanine with concomitant oxidation of NADH to NAD+ and has a homohexameric ...
Ji-A, Jeong, Jeong-Il, Oh
openaire   +2 more sources

Amperometric Alanine Electrode

Analytical Letters, 1993
Abstract An amperometric enzyme electrode for L-Alanine determination was developed. The probe is based on a platinum electrode which senses the hydrogen peroxide produced by the enzymatic reactions catalyzed by two enzymes: alanine aminotransferase (ALT) and glutamate oxidase.
PALLESCHI, GIUSEPPE, VOLPE, GIULIA, D. Compagnone, M. G. Lavagnini, MOSCONE DINIA, DANILA, A. Amine   +5 more
openaire   +4 more sources

Brivanib alaninate for cancer

Expert Opinion on Investigational Drugs, 2011
Angiogenesis inhibition represents a rational therapeutic strategy in the management of solid tumors. Brivanib is a dual tyrosine kinase inhibitor with selectivity against VEFGR-2 and FGFR.This review provides an updated summary of preclinical and clinical experience with brivanib in cancer.
Ivan, Diaz-Padilla, Lillian L, Siu
openaire   +2 more sources

Inactivation of alanine aminotransferase by the neurotoxin β-cyano-L-alanine

Biochemical and Biophysical Research Communications, 1980
Abstract β-Cyano-L-alanine inactivates pig heart alanine aminotransferase. The nitrile and enzyme form a freely dissociable Michaelis complex which rearranges to a form of inactive enzyme. The inactivated enzyme slowly recovers activity at 25° in 100 mM phosphate buffer, pH 7.4. The observations are consistent with a mechanism of inactivation similar
T A, Alston, D J, Porter, L, Mela, H J, Bright   +3 more
openaire   +2 more sources

Serum alanine assay with an enzymic micromethod (L-alanine dehydrogenase)

Clinica Chimica Acta, 1978
L-Alanine was measured by an enzymic micromethod in serum after treatment with perchloric acid, as well as after ultrafiltration through collodium membrane filters. Serum L-alanine was also determined by an automated column chromatographic technique. Using the enzymic method, spuriously increased L-alanine levels could be obtained due to the absorbent ...
A, Berg, W, Gerok, J, Keul
openaire   +2 more sources

Diazenedicarboxamides as inhibitors of d-alanine-d-alanine ligase (Ddl)

Bioorganic & Medicinal Chemistry Letters, 2007
D-Alanine-D-alanine ligase (Ddl) catalyzes the biosynthesis of an essential bacterial peptidoglycan precursor D-alanyl-D-alanine and it represents an important target for development of new antibacterial drugs. A series of semicarbazides, aminocarbonyldiazenecarboxylates, diazenedicarboxamides, and hydrazinedicarboxamides was synthesized and screened ...
Andreja, Kovac, Vita, Majce, Roman, Lenarsic, Sergeja, Bombek, Julieanne M, Bostock, Ian, Chopra, Slovenko, Polanc, Stanislav, Gobec   +7 more
openaire   +2 more sources

The glucose-alanine cycle

Metabolism, 1973
Abstract Alanine is quantitatively the primary amino acid released by muscle and extracted by the splanchnic bed in postabsorptive as well as prolonged fasted man. The hepatic capacity for conversion of alanine to glucose exceeds that of all other amino acids. Insulin inhibits gluconeogenesis by reducing hepatic alanine uptake.
openaire   +2 more sources

Isotope tracing in adult zebrafish reveals alanine cycling between melanoma and liver

Cell Metabolism, 2021
Ryan Fields, Ethan Stancliffe, Jonathan Spalding   +2 more
exaly  

Enzymatic determination of d-alanine with l-alanine dehydrogenase and alanine racemase

Bioscience, Biotechnology and Biochemistry, 2021
Yoshihiro Sawa, Tohru Yoshimura
exaly  

Alanine

2021
openaire   +1 more source