l-Aspartate: An Essential Metabolite for Plant Growth and Stress Acclimation
Molecules, 2021 L-aspartate (Asp) serves as a central building block, in addition to being a constituent of proteins, for many metabolic processes in most organisms, such as biosynthesis of other amino acids, nucleotides, nicotinamide adenine dinucleotide (NAD), the ...
Mei Han +5 more
doaj +2 more sources
Aspartate availability limits hematopoietic stem cell function during hematopoietic regeneration
Cell Stem Cell, 2021 SUMMARY The electron transport chain promotes aspartate synthesis, which is required for cancer cell proliferation. However, it is unclear whether aspartate is limiting in normal stem cells.
Zhiyu Zhao +2 more
exaly +2 more sources
Aspartate Metabolism Facilitates IL-1β Production in Inflammatory Macrophages
Frontiers in Immunology, 2021 Increasing evidence support that cellular amino acid metabolism shapes the fate of immune cells; however, whether aspartate metabolism dictates macrophage function is still enigmatic.
Hao Wang +9 more
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Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting
Cell Metabolism, 2018 Summary Mitochondrial function is important for aspartate biosynthesis in proliferating cells. Here, we show that mitochondrial aspartate export via the aspartate-glutamate carrier 1 (AGC1) supports cell proliferation and cellular redox homeostasis ...
Sarah Stryeck +2 more
exaly +2 more sources
Cell Metabolism, 2016 Summary Metformin use is associated with reduced cancer mortality, but how metformin impacts cancer outcomes is controversial. While metformin can act cell autonomously to inhibit tumor growth, the doses of metformin that inhibit proliferation in tissue ...
Shawn Davidson +2 more
exaly +2 more sources
Alterations in Liver Enzymes in the Postoperative Period Following Laparoscopic and Open Cholecystectomy: A Prospective Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Laparoscopic Cholecystectomy (LC) is one of the most common procedures that is being performed by a general surgeon, and is the treatment of choice for symptomatic gallstone disease.
Upasana Choudhury, Partha Sarathi Dutta
doaj +1 more source
Roles of malate and aspartate in gluconeogenesis in various physiological and pathological states.
Metabolism: Clinical and Experimental, 2023 Gluconeogenesis, a pathway for glucose synthesis from non-carbohydrate substances, begins with the synthesis of oxaloacetate (OA) from pyruvate and intermediates of citric acid cycle in hepatocyte mitochondria.
M. Holeček
semanticscholar +1 more source
Gut microbes, 2021 The gut bacterium Akkermansia muciniphila has been increasingly recognized for its therapeutic potential in treating metabolic disorders, including obesity, diabetes, and metabolicdysfunction-associated fatty liver disease (MAFLD).
Yong Rao +15 more
semanticscholar +1 more source
Changes in alanine aminotransfearase, aspartate aminotransfearase in blasma, kidney and liver in rabbits treated with cadmium chloride [PDF]
Iraqi Journal of Veterinary Sciences, 2006 The study was designed to investigate the subchronic toxic effect of cadmium chloride administered orally on alanine aminotransfearase (ALT), aspartate aminotransfearase (AST) activity and certain tissues in adult male rabbits.
K. A. Mohi-Aldeen
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Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells
eLife, 2023 The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating catabolic conversions of NAD +to NADH and anabolic production of aspartate, a key amino acid for cell proliferation.
Madeleine L Hart +8 more
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