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Role of Aspartate in Immune Response and Mortality in a Polymicrobial Sepsis Model: Insights from Metabolomics and Transcriptomics [PDF]
CellsSepsis is a life-threatening syndrome characterized by dysregulated host responses to infection. In addition to early hyperinflammation, many patients develop profound immune suppression, and multiple targeted immunotherapies have failed to improve ...
Min Ji Lee +19 more
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Alterations in Liver Enzymes in the Postoperative Period Following Laparoscopic and Open Cholecystectomy: A Prospective Study [PDF]
Journal of Clinical and Diagnostic Research, 2023 Introduction: Laparoscopic Cholecystectomy (LC) is one of the most common procedures that is being performed by a general surgeon, and is the treatment of choice for symptomatic gallstone disease.
Upasana Choudhury, Partha Sarathi Dutta
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l-Aspartate: An Essential Metabolite for Plant Growth and Stress Acclimation
Molecules, 2021 L-aspartate (Asp) serves as a central building block, in addition to being a constituent of proteins, for many metabolic processes in most organisms, such as biosynthesis of other amino acids, nucleotides, nicotinamide adenine dinucleotide (NAD), the ...
Mei Han +5 more
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Changes in alanine aminotransfearase, aspartate aminotransfearase in blasma, kidney and liver in rabbits treated with cadmium chloride [PDF]
Iraqi Journal of Veterinary Sciences, 2006 The study was designed to investigate the subchronic toxic effect of cadmium chloride administered orally on alanine aminotransfearase (ALT), aspartate aminotransfearase (AST) activity and certain tissues in adult male rabbits.
K. A. Mohi-Aldeen
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Mitochondrial redox adaptations enable alternative aspartate synthesis in SDH-deficient cells
eLife, 2023 The oxidative tricarboxylic acid (TCA) cycle is a central mitochondrial pathway integrating catabolic conversions of NAD +to NADH and anabolic production of aspartate, a key amino acid for cell proliferation.
Madeleine L Hart +8 more
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Amino Acid Oncometabolism and Immunomodulation of the Tumor Microenvironment in Lung Cancer
Frontiers in Oncology, 2020 The observation that cancer acquires significant changes in its metabolism dates back nearly a century, to Otto Warburg noting that cancer cells preferentially utilize glycolysis even when there are no hypoxic conditions in the growth media.
Johannes F. Fahrmann +2 more
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Frontiers in Veterinary Science, 2023 Aspartate (asp), glutamate (glu), and glutamine (gln) are the major energy fuels for the small intestine, and it had been indicated in our previous study that the mix of these three amino acid supplementations could maintain intestinal energy homeostasis.
Yuankun Deng +8 more
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Frontiers in Genetics, 2021 Mycobacterium tuberculosis harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in M. tuberculosis persistence and disease.
Soumyanetra Chandra +2 more
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The roles of organic acids in C4 photosynthesis
Frontiers in Plant Science, 2016 Organic acids are involved in numerous metabolic pathways in all plants. The finding that some plants, known as C4 plants, have four-carbon dicarboxylic acids as the first product of carbon fixation showed these organic acids play essential roles as ...
Martha eLudwig
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Plants, 2022 Aspartate is the most critical amino acid in the aspartate metabolic pathway, which is associated with multiple metabolic pathways, such as protein synthesis, nucleotide metabolism, TCA cycle, glycolysis, and hormone biosynthesis. Aspartate also plays an
Shuhan Lei +2 more
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