Results 1 to 10 of about 2,037,833 (287)

Localisation of gluconeogenesis and tricarboxylic acid (TCA)-cycle enzymes and first functional analysis of the TCA cycle in Toxoplasma gondii

International Journal for Parasitology, 2008
The apicomplexan parasite Toxoplasma gondii displays some unusual localisations of carbohydrate converting enzymes, which is due to the presence of a vestigial, non-photosynthetic plastid, referred to as the apicoplast. It was recently demonstrated that the single pyruvate dehydrogenase complex (PDH) in T.
Wolfgang Bohne
exaly   +5 more sources

Changes in TCA cycle and TCA cycle-related metabolites in plasma upon citric acid administration in rats [PDF]

Heliyon, 2021
Recent studies have reported that plasma levels of tricarboxylic acid (TCA) cycle metabolites and TCA cycle-related metabolite change in patients with chronic fatigue syndrome (CFS) and in healthy humans after exercise. Exogenous dietary citric acid has been reported to alleviate fatigue during daily activities and after exercise.
Yurie Hara, Satoshi Kume, Yosky Kataoka, Nakamichi Watanabe   +3 more
openaire   +4 more sources

The Role of TCA Cycle Enzymes in Plants

Advanced Biology, 2023
AbstractAs one of the iconic pathways in plant metabolism, the tricarboxylic acid (TCA) cycle is commonly thought to not only be responsible for the oxidization of respiratory substrate to drive ATP synthesis but also provide carbon skeletons to anabolic processes and contribute to carbon–nitrogen interaction and biotic stress responses.
Youjun Zhang, Alisdair R. Fernie
openaire   +4 more sources

Operation of a TCA cycle subnetwork in the mammalian nucleus [PDF]

Science Advances, 2022
Nucleic acid and histone modifications critically depend on the tricarboxylic acid (TCA) cycle for substrates and cofactors. Although a few TCA cycle enzymes have been reported in the nucleus, the corresponding pathways are considered to operate in mitochondria.
Kafkia, Eleni, Andres-Pons, Amparo, Ganter, Kerstin, Seiler, Markus, Smith, Tom S., Andrejeva, Anna, Jouhten, Paula, Pereira, Filipa, Franco, Catarina, Kuroshchenkova, Anna, Leone, Sergio, Sawarkar, Ritwick, Boston, Rebecca, Thaventhiran, James, Zaugg, Judith B., Lilley, Kathryn S., Lancrin, Christophe, Beck, Martin, Patil, Kiran Raosaheb   +19 more
openaire   +9 more sources

Identification and characterization of the TCA cycle genes in maize [PDF]

BMC Plant Biology, 2019
Abstract Background The tricarboxylic acid (TCA) cycle is crucial for cellular energy metabolism and carbon skeleton supply. However, the detailed functions of the maize TCA cycle genes remain unclear. Results In this study, 91 TCA genes were identified in maize by a ...
Yongming Liu, Jingtao Qu, Ling Zhang, Xiangyu Xu, Gui Wei, Zhuofan Zhao, Maozhi Ren, Moju Cao   +7 more
openaire   +3 more sources

Rescue of TCA Cycle Dysfunction for Cancer Therapy [PDF]

Journal of Clinical Medicine, 2019
Mitochondrion, a maternally hereditary, subcellular organelle, is the site of the tricarboxylic acid (TCA) cycle, electron transport chain (ETC), and oxidative phosphorylation (OXPHOS)—the basic processes of ATP production. Mitochondrial function plays a pivotal role in the development and pathology of different cancers.
Marquez, Jubert, Flores, Jessa, Kim, Amy Hyein, Nyamaa, Bayalagmaa, Nguyen, Anh Thi Tuyet, Park, Nammi, Han, Jin   +6 more
openaire   +3 more sources

Noncanonical TCA cycle fosters canonical TCA cycle and mitochondrial integrity in acute myeloid leukemia. [PDF]

Cancer Sci
AbstractCancer cells rely on mitochondrial oxidative phosphorylation (OXPHOS) and the noncanonical tricarboxylic acid (TCA) cycle. In this paper, we shed light on the vital role played by the noncanonical TCA cycle in a host‐side concession to mitochondria, especially in highly energy‐demanding malignant tumor cells.
Watanabe A, Tipgomut C, Totani H, Yoshimura K, Iwano T, Bashiri H, Chua LH, Yang C, Suda T.   +8 more
europepmc   +3 more sources

TCA cycle signalling and the evolution of eukaryotes

Current Opinion in Biotechnology, 2021
A major question remaining in the field of evolutionary biology is how prokaryotic organisms made the leap to complex eukaryotic life. The prevailing theory depicts the origin of eukaryotic cell complexity as emerging from the symbiosis between an α-proteobacterium, the ancestor of present-day mitochondria, and an archaeal host (endosymbiont theory). A
Ryan, Dylan G, Frezza, Christian, O'Neill, Luke Aj   +2 more
openaire   +3 more sources

The role and regulatory mechanisms of the TCA cycle in early embryonic development [PDF]

Frontiers in Cell and Developmental Biology
Liwen Zhao
exaly   +2 more sources

TCA cycle-powered synthesis of fucosylated oligosaccharides [PDF]

Glycobiology, 2018
Microbial catalysis has recently emerged as one of the most promising approaches in oligosaccharide synthesis. However, despite significant progress, microbial synthesis still requires much improvement in efficiency and in reduction of process complexity. Additionally, given the stunning diversity and many varied applications of glycans, broadening the
Ningzi, Guan, Hyun-Dong, Shin, Lingfeng, Long, Parastoo, Azadi, Rachel, Chen   +4 more
openaire   +2 more sources