Results 31 to 40 of about 2,037,833 (287)
TCA cycle intermediates as an adjunct strategy for human iPSC-derived cardiomyocyte maturation. [PDF]
BBA AdvHuman induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) are a valuable tool for modeling cardiac diseases, drug testing, and regenerative applications. However, their application is limited by the immature phenotype of iPSC-CM.
Alagarsamy KN +4 more
europepmc +2 more sources
BMC Genomics, 2021 Background The tricarboxylic acid (TCA) cycle is crucial for energy supply in animal, plant, and microbial cells. It is not only the main pathway of carbohydrate catabolism but also the final pathway of lipid and protein catabolism.
Yongming Liu +4 more
doaj +1 more source
Figure 3: Krebs (TCA) Cycle Intermediates
, 2019 The center diagram depicts the TCA cycle following pyruvate oxidation, and the graphs show the quantitative comparisons of TCA intermediates in cardiac tissue of NDs and at the pre- and post-LVAD time points.
Abdallah G. Kfoury (434257) +17 more
core +1 more source
Journal of Analytical Methods in Chemistry, 2017 It is now well-established that perturbations in the tricarboxylic acid (TCA) cycle play an important role in the metabolic transformation occurring in cancer including that of the prostate. A method for simultaneous qualitative and quantitative analysis
Omar Al Kadhi +3 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Revisiting the TCA cycle: signaling to tumor formation [PDF]
Trends in Molecular Medicine, 2011 A role for mitochondria in tumor formation is suggested by mutations in enzymes of the TCA cycle: isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH) and fumarate hydratase (FH). Although they are all components of the TCA cycle, the resulting clinical presentations do not overlap. Activation of the hypoxia pathway can explain SDH phenotypes,
Nuno, Raimundo +2 more
openaire +2 more sources
Extracellular pH modulates TCA cycle metabolism.
, 2016 Targeted GC/MS quantification of TCA cycle metabolites (A) malate, (B) fumarate, and (C) succinate in PNEC cells demonstrate that TCA cycle metabolite levels increase with alkalinization.
Jan R. Crowley (13141) +10 more
core +1 more source
Nature Communications, 2018 The citric acid cycle (TCA) is a fundamental metabolic pathway to release stored energy in living organisms. Here, the authors report two linked cycles of reactions that each oxidize glyoxylate into CO2 and generate intermediates shared with the modern ...
Greg Springsteen +4 more
doaj +1 more source