Results 21 to 30 of about 2,037,833 (287)

Succinyl-CoA:acetate CoA-transferase functioning in the oxidative tricarboxylic acid cycle in Desulfurella acetivorans

Frontiers in Microbiology, 2022
Desulfurella acetivorans is a strictly anaerobic sulfur-reducing deltaproteobacterium that possesses a very dynamic metabolism with the ability to revert the citrate synthase version of the tricarboxylic acid (TCA) cycle for autotrophic growth (reversed ...
Eugenio Pettinato, Pauline Böhnert, Ivan A. Berg   +2 more
doaj   +1 more source

TCA cycle rewiring as emerging metabolic signature of hepatocellular carcinoma [PDF]

, 2020
Hepatocellular carcinoma (HCC) is a common malignancy. Despite progress in treatment, HCC is still one of the most lethal cancers. Therefore, deepening molecular mechanisms underlying HCC pathogenesis and development is required to uncover new ...
Todisco S., Infantino V., Convertini P., Iacobazzi V.   +3 more
core   +2 more sources

A tricarboxylic acid cycle-based machine learning model to select effective drug targets for the treatment of esophageal squamous cell carcinoma

Frontiers in Pharmacology, 2023
Background: The tricarboxylic acid cycle (TCA cycle) is an important metabolic pathway and closely related to tumor development. However, its role in the development of esophageal squamous cell carcinoma (ESCC) has not been fully investigated.Methods ...
Yicheng Liang, Yicheng Liang, Yicheng Liang, Binghua Tan, Binghua Tan, Minjun Du, Bing Wang, Yushun Gao, Minghui Wang, Minghui Wang   +9 more
doaj   +1 more source

Integrated metabolomic and gut microbiota analyses reveal TCA cycle dysfunction in broiler skeletal disorders and the protective effect of L‑malic acid. [PDF]

J Anim Sci Biotechnol
Background Skeletal disorders pose a significant challenge to intensive broiler production. However, the metabolic mechanisms underlying the development of skeletal abnormalities in broilers remain unclear.
Xue Y, Yao M, Peng X, Wang F, Jing W, Zhang F, Mi L, Zhang W, Nie C.   +8 more
europepmc   +2 more sources

Fatty acid feedstocks enable a highly efficient glyoxylate‐TCA cycle for high‐yield production of β‐alanine

mLife, 2022
Metabolic engineering to produce tricarboxylic acid (TCA) cycle‐derived chemicals is usually associated with problems of low production yield and impaired cellular metabolism. In this work, we found that fatty acid (FA) feedstocks could enable high‐yield
Yingchun Miao, Jiao Liu, Xuanlin Wang, Bo Liu, Weifeng Liu, Yong Tao   +5 more
doaj   +1 more source

Integration of the tricarboxylic acid (TCA) cycle with cAMP signaling and Sfl2 pathways in the regulation of CO2 sensing and hyphal development in Candida albicans.

PLoS Genetics, 2017
Morphological transitions and metabolic regulation are critical for the human fungal pathogen Candida albicans to adapt to the changing host environment. In this study, we generated a library of central metabolic pathway mutants in the tricarboxylic acid
Li Tao, Yulong Zhang, Shuru Fan, Clarissa J Nobile, Guobo Guan, Guanghua Huang   +5 more
doaj   +1 more source

Systemic alterations of tricarboxylic acid cycle enzymes in Alzheimer’s disease

Frontiers in Neuroscience, 2023
Mitochondrial dysfunction, especially tricarboxylic acid (TCA) cycle arrest, is strongly associated with Alzheimer’s disease (AD), however, its systemic alterations in the central and peripheral of AD patients are not well defined.
Dongdong Jia, Fangzhou Wang, Haitao Yu, Haitao Yu   +3 more
doaj   +1 more source

Glucose feeds the TCA cycle via circulating lactate [PDF]

, 2017
Mammalian tissues are fuelled by circulating nutrients, including glucose, amino acids, and various intermediary metabolites. Under aerobic conditions, glucose is generally assumed to be burned fully by tissues via the tricarboxylic acid cycle (TCA cycle)
Hui, Sheng, Jang, Cholsoon, Teng, Xin, et al, Morscher, Raphael J; https://orcid.org/, Ghergurovich, Jonathan M   +5 more
core   +3 more sources

A Dysfunctional Tricarboxylic Acid Cycle Enhances Fitness of Staphylococcus epidermidis During β-Lactam Stress

mBio, 2013
A recent controversial hypothesis suggested that the bactericidal action of antibiotics is due to the generation of endogenous reactive oxygen species (ROS), a process requiring the citric acid cycle (tricarboxylic acid [TCA] cycle).
Vinai Chittezham Thomas, Lauren C. Kinkead, Ashley Janssen, Carolyn R. Schaeffer, Keith M. Woods, Jill K. Lindgren, Jonathan M. Peaster, Sujata S. Chaudhari, Marat Sadykov, Joselyn Jones, Sameh M. Mohamadi AbdelGhani, Matthew C. Zimmerman, Kenneth W. Bayles, Greg A. Somerville, Paul D. Fey   +14 more
doaj   +1 more source

Reduced TCA Flux in Diabetic Myotubes: Determined by Single Defects?

Biochemistry Research International, 2012
The diabetic phenotype is complex, requiring elucidation of key initiating defects. Diabetic myotubes express a primary reduced tricarboxylic acid (TCA) cycle flux but at present it is unclear in which part of the TCA cycle the defect is localised.
Michael Gaster
doaj   +1 more source