Results 1 to 10 of about 81,191 (254)
Systemic alterations of tricarboxylic acid cycle enzymes in Alzheimer’s disease [PDF]
Frontiers in Neuroscience, 2023 Mitochondrial dysfunction, especially tricarboxylic acid (TCA) cycle arrest, is strongly associated with Alzheimer’s disease (AD), however, its systemic alterations in the central and peripheral of AD patients are not well defined.
Dongdong Jia +3 more
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Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses
Life, 2021 The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic organisms to generate energy via the oxidation of acetylcoenzyme A (CoA) derived from carbohydrates, fatty acids and proteins.
Inseok Choi, Hyewon Son, Jea-Hyun Baek
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The Role of Tricarboxylic Acid Cycle Metabolites in Viral Infections
Frontiers in Cellular and Infection Microbiology, 2021 Host cell metabolism is essential for the viral replication cycle and, therefore, for productive infection. Energy (ATP) is required for the receptor-mediated attachment of viral particles to susceptible cells and for their entry into the cytoplasm. Host
Francisco Javier Sánchez-García +3 more
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The Methylcitrate Cycle and Its Crosstalk with the Glyoxylate Cycle and Tricarboxylic Acid Cycle in Pathogenic Fungi [PDF]
Molecules, 2023 In fungi, the methylcitrate cycle converts cytotoxic propionyl-coenzyme A (CoA) to pyruvate, which enters gluconeogenesis. The glyoxylate cycle converts acetyl-CoA to succinate, which enters gluconeogenesis.
Zhicheng Huang +8 more
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Cell Reports, 2019 Summary: Increased glycolysis parallels immune cell activation, but the role of pyruvate remains largely unexplored. We found that stimulation of dendritic cells with the fungal surrogate zymosan causes decreases of pyruvate, citrate, itaconate, and α ...
Saioa Márquez +10 more
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Tracking the Reversed Oxidative Tricarboxylic Acid Cycle in Bacteria
Bio-Protocol, 2022 Different pathways for autotrophic CO2 fixation can be recognized by the presence of genes for their specific key enzymes. On this basis, (meta)genomic, (meta)transcriptomic, or (meta)proteomic analysis enables the identification of the role of an ...
Lydia Steffens +4 more
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Involvement of Tricarboxylic Acid Cycle Metabolites in Kidney Diseases
Biomolecules, 2021 Mitochondria are complex organelles that orchestrate several functions in the cell. The primary function recognized is energy production; however, other functions involve the communication with the rest of the cell through reactive oxygen species (ROS ...
Alexis Paulina Jiménez-Uribe +3 more
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Signals from the Circle: Tricarboxylic Acid Cycle Intermediates as Myometabokines
Metabolites, 2021 Regular physical activity is an effective strategy to prevent and ameliorate aging-associated diseases. In particular, training increases muscle performance and improves whole-body metabolism.
Jennifer Maurer +2 more
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Molecules, 2023 When the expression of NOS2 in M1-polarized macrophages is induced, huge amounts of nitric oxide (•NO) are produced from arginine and molecular oxygen as the substrates.
Junichi Fujii, Tsukasa Osaki
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Role of Oxidative Stress in Mitochondrial Function: Relevance for Liver Function
Antioxidants, 2023 The traditional recognition of mitochondria as powerhouses that generate ATP and reactive oxygen species (ROS) via oxidative phosphorylation and the tricarboxylic acid cycle has ceased [...]
Jie Xu, Zhihui Feng
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