Results 11 to 20 of about 81,191 (254)
Xylose-induced tricarboxylic acid cycle activation resensitizes gentamicin-resistant Escherichia coli [PDF]
Applied and Environmental MicrobiologyThe escalating antibiotic resistance crisis requires innovative strategies to revitalize existing antibiotics. Here, we report that xylose, a food-grade sugar poorly metabolized by humans but readily utilized by bacteria, acts as a potent metabolic ...
Ling Chen +5 more
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Tricarboxylic Acid Cycle Intermediates and Individual Ageing [PDF]
BiomoleculesAnti-ageing biology and medicine programmes are a focus of genetics, molecular biology, immunology, endocrinology, nutrition, and therapy. This paper discusses metabolic therapies aimed at prolonging longevity and/or health.
Natalia Kurhaluk
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The Tricarboxylic Acid Cycle Metabolites for Cancer: Friend or Enemy [PDF]
ResearchThe tricarboxylic acid (TCA) cycle is capable of providing sufficient energy for the physiological activities under aerobic conditions. Although tumor metabolic reprogramming places aerobic glycolysis in a dominant position, the TCA cycle remains ...
Jie Wu +7 more
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Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients [PDF]
BMC MedicineBackground Disrupted tricarboxylic acid (TCA) cycle metabolism drives ischemic mitochondrial stress in the pathophysiology of acute myocardial infarction (AMI), yet its clinical prognostic utility remains poorly defined. This study aimed to (1) develop a
Ye Wang +7 more
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LINC00571 drives tricarboxylic acid cycle metabolism in triple-negative breast cancer through HNRNPK/ILF2/IDH2 axis [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Triple-negative breast cancer is a complex breast malignancy subtype characterized by poor prognosis. The pursuit of effective therapeutic approaches for this subtype is considerably challenging.
Zihan Xi +10 more
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Frontiers in Fungal Biology, 2022 The growth and development of organisms depend on nutrient availability. Dermatophytes must sense nutrient levels and adapt to the host environment to colonize human and animal keratinized tissues.
Aline H. S. Cruz +9 more
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Frontiers in Microbiology, 2022 Desulfurella acetivorans is a strictly anaerobic sulfur-reducing deltaproteobacterium that possesses a very dynamic metabolism with the ability to revert the citrate synthase version of the tricarboxylic acid (TCA) cycle for autotrophic growth (reversed ...
Eugenio Pettinato +2 more
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Molecular Metabolism, 2022 Objectives: Glucocorticoids (GCs) are one of the most widely prescribed anti-inflammatory drugs. By acting through their cognate receptor, the glucocorticoid receptor (GR), GCs downregulate the expression of pro-inflammatory genes and upregulate the ...
Ulrich Stifel +15 more
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Ketogenic diet in action: Metabolic profiling of pyruvate dehydrogenase deficiency
Molecular Genetics and Metabolism Reports, 2023 The pyruvate dehydrogenase complex serves as the main connection between cytosolic glycolysis and the tricarboxylic acid cycle within mitochondria. An infant with pyruvate dehydrogenase complex deficiency was treated with vitamin B1 supplementation and a
Eri Ogawa +6 more
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Edwardsiella tarda Tunes Tricarboxylic Acid Cycle to Evade Complement-Mediated Killing
Frontiers in Immunology, 2017 Evasion of complement-mediated killing is a common phenotype for many different types of pathogens, but the mechanism is still poorly understood. Most of the clinic isolates of Edwardsiella tarda, an important pathogen infecting both of human and fish ...
Zhi-xue Cheng +10 more
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