Results 11 to 20 of about 2,037,833 (287)
Tricarboxylic Acid (TCA) Cycle Intermediates: Regulators of Immune Responses
Life, 2021 The tricarboxylic acid cycle (TCA) is a series of chemical reactions used in aerobic organisms to generate energy via the oxidation of acetylcoenzyme A (CoA) derived from carbohydrates, fatty acids and proteins.
Hyewon Son, Jea-Hyun Baek, Inseok Choi
core +2 more sources
Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism [PDF]
eLife, 2021 The Tricarboxylic Acid Cycle (TCA) cycle is arguably the most critical metabolic cycle in physiology and exists as an essential interface coordinating cellular metabolism, bioenergetics, and redox homeostasis. Despite decades of research, a comprehensive
Prag, Hiran A.; id_orcid +13 more
core +9 more sources
TCA Cycle Defects and Cancer: When Metabolism Tunes Redox State [PDF]
International Journal of Cell Biology, 2012 Inborn defects of the tricarboxylic acid (TCA) cycle enzymes have been known for more than twenty years. Until recently, only recessive mutations were described which, although resulted in severe multisystem syndromes, did not predispose to cancer onset.
Simone Cardaci +4 more
core +2 more sources
mBio, 2022 Oxygenic photoautotrophic bacteria, cyanobacteria, have the tricarboxylic acid (TCA) cycle, and metabolite production using the cyanobacterial TCA cycle has been spotlighted recently. The unicellular cyanobacterium Synechocystis sp.
Noriaki Katayama +4 more
doaj +1 more source
Emerging role of the TCA cycle and its metabolites in lung disease. [PDF]
Front PhysiolThe TCA cycle is a central pathway for oxidative phosphorylation in eukaryotic mitochondria, plays a role in energy production and biosynthesis, and can alter cellular function in a variety of ways.
Lu X +5 more
europepmc +2 more sources
The Role of Tricarboxylic Acid Cycle Metabolites in Viral Infections
Frontiers in Cellular and Infection Microbiology, 2021 Host cell metabolism is essential for the viral replication cycle and, therefore, for productive infection. Energy (ATP) is required for the receptor-mediated attachment of viral particles to susceptible cells and for their entry into the cytoplasm. Host
Francisco Javier Sánchez-García +3 more
doaj +1 more source
Harnessing the glycolysis-TCA cycle axis to boost host defense against neonatal infection. [PDF]
EMBO Mol MedPreterm infants are highly susceptible to infections that can lead to sepsis, yet therapies beyond antibiotics are limited. Nutrition and host energy metabolism are known as immune modulators, but how they interact to mediate newborn host infection ...
Wu Z +17 more
europepmc +2 more sources
The TGF-β/HDAC7 axis suppresses TCA cycle metabolism in renal cancer
JCI Insight, 2021 Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma (RCC). However, the mechanisms that regulate the TCA cycle in RCC remain uncharacterized.
Hyeyoung Nam +11 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2021 The scope and variety of the metabolic intermediates from the mitochondrial tricarboxylic acid (TCA) cycle that are engaged in epigenetic regulation of the chromatin function in the nucleus raise an outstanding question about how timely and precise ...
Xujun Liu +22 more
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The TCA cycle—mitochondrial version.
, 2022 The TCA cycle—mitochondrial version.
Morten Beck Rye (14009114) +3 more
core +1 more source