Results 21 to 30 of about 572,945 (313)

Adaptive stimulation of macropinocytosis overcomes aspartate limitation in cancer cells under hypoxia

Nature Metabolism, 2021
Stress-adaptive mechanisms enable tumour cells to overcome metabolic constraints under nutrient and oxygen shortage. Aspartate is an endogenous metabolic limitation under hypoxic conditions, but the nature of the adaptive mechanisms that contribute to ...
J. Garcia-Bermudez, Michael A. Badgley, S. Prasad, Lou Baudrier, Yuyang Liu, Konnor C. La, Mariluz Soula, Robert T. Williams, N. Yamaguchi, R. Hwang, L. Taylor, E. de Stanchina, B. Rostandy, Hanan Alwaseem, H. Molina, D. Bar-Sagi, Kıvanç Birsoy   +16 more
semanticscholar   +1 more source

Enzyme Nanosheet-Based Electrochemical Aspartate Biosensor for Fish Point-of-Care Applications

Micromachines, 2022
Bacterial infections in marine fishes are linked to mass mortality issues; hence, rapid detection of an infection can contribute to achieving a faster diagnosis using point-of-care testing.
Thenmozhi Rajarathinam, Dinakaran Thirumalai, Sivaguru Jayaraman, Seonghye Kim, Minho Kwon, Hyun-jong Paik, Suhkmann Kim, Mijeong Kang, Seung-Cheol Chang   +8 more
doaj   +1 more source

Aspartate metabolic flux promotes nitric oxide to eliminate both antibiotic-sensitive and -resistant Edwardsiella tarda in zebrafish

Frontiers in Immunology, 2023
IntroductionMetabolic reprogramming potentiates host protection against antibiotic-sensitive or -resistant bacteria. However, it remains unclear whether a single reprogramming metabolite is effective enough to combat both antibiotic-sensitive and ...
Jiao Xiang, Min-yi Li, Hui Li, Hui Li, Hui Li, Hui Li   +5 more
doaj   +1 more source

An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis

Cell, 2015
Summary The mitochondrial electron transport chain (ETC) enables many metabolic processes, but why its inhibition suppresses cell proliferation is unclear.
Kıvanç Birsoy, Tim Wang, Walter W. Chen, Elizaveta Freinkman, Monther Abu-Remaileh, D. Sabatini   +5 more
semanticscholar   +1 more source

p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival

Nature Communications, 2020
Asparagine synthetase (ASNS) catalyses the ATP-dependent conversion of aspartate to asparagine. However, both the regulation and biological functions of asparagine in tumour cells remain largely unknown.
Longfei Deng, Pengbo Yao, Le Li, Fansen Ji, Shuang Zhao, Chang Xu, Xun Lan, P. Jiang   +7 more
semanticscholar   +1 more source

Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community

eLife, 2020
Previously, we found that in glucose-limited Saccharomyces cerevisiae colonies, metabolic constraints drive cells into groups exhibiting gluconeogenic or glycolytic states.
Sriram Varahan, Vaibhhav Sinha, Adhish Walvekar, Sandeep Krishna, Sunil Laxman   +4 more
doaj   +1 more source

An Asp to Strike Out Cancer? Therapeutic Possibilities Arising from Aspartate’s Emerging Roles in Cell Proliferation and Survival

Biomolecules, 2021
A better understanding of the metabolic constraints of a tumor may lead to more effective anticancer treatments. Evidence has emerged in recent years shedding light on a crucial aspartate dependency of many tumor types.
Iiro Taneli Helenius, Hanumantha Rao Madala, Jing-Ruey Joanna Yeh   +2 more
doaj   +1 more source

Chloroquine Triggers Cell Death and Inhibits PARPs in Cell Models of Aggressive Hepatoblastoma

Frontiers in Oncology, 2020
Background: Hepatoblastoma (HB) is the most common pediatric liver malignancy. Despite advances in chemotherapeutic regimens and surgical techniques, the survival of patients with advanced HB remains poor, underscoring the need for new therapeutic ...
Katja Eloranta, Stefano Cairo, Emmi Liljeström, Tea Soini, Tea Soini, Antti Kyrönlahti, Jean-Gabriel Judde, David B. Wilson, David B. Wilson, Markku Heikinheimo, Markku Heikinheimo, Marjut Pihlajoki   +11 more
doaj   +1 more source

Studying the Excitotoxic Amino Acids Impact on the Degree of Impairment of Consciousness in Purulent Meningitises in Children

Zdorovʹe Rebenka, 2013
The study revealed a strong and significant inverse correlation between the level of excitatory neurotransmitter amino acid of glutamate, aspartate in the blood serum and level of consciousness according to Glasgow Coma Scale.
L.V. Pypa, Т.V. Svistilnik
doaj   +1 more source

Acute severe hepatotoxicity associated with clomipramine

Psychiatry and Clinical Psychopharmacology, 2021
Miss Y. presented with complaints of irritability, depressed mood, avolition, anhedonia, markedly decreased appetite and around 10 kg weight loss within two months, amenorrhea, dysmorphophobia, and psychomotor retardation.
Murad Atmaca
doaj   +1 more source