Results 11 to 20 of about 572,945 (313)
Molecular Therapy, 2022 Amino acids metabolism, especially aspartate metabolism, is often altered in human cancers including hepatocellular carcinoma (HCC) and this metabolic remodeling is required for supporting cancer cell malignant activities.
Muhua Chen +5 more
semanticscholar +1 more source
Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation
Nature Immunology, 2021 Misdirected immunity gives rise to the autoimmune tissue inflammation of rheumatoid arthritis, in which excess production of the cytokine tumor necrosis factor (TNF) is a central pathogenic event. Mechanisms underlying the breakdown of self-tolerance are
Bowen Wu +7 more
semanticscholar +1 more source
Amino Acid Oncometabolism and Immunomodulation of the Tumor Microenvironment in Lung Cancer
Frontiers in Oncology, 2020 The observation that cancer acquires significant changes in its metabolism dates back nearly a century, to Otto Warburg noting that cancer cells preferentially utilize glycolysis even when there are no hypoxic conditions in the growth media.
Johannes F. Fahrmann +2 more
doaj +1 more source
Frontiers in Veterinary Science, 2023 Aspartate (asp), glutamate (glu), and glutamine (gln) are the major energy fuels for the small intestine, and it had been indicated in our previous study that the mix of these three amino acid supplementations could maintain intestinal energy homeostasis.
Yuankun Deng +8 more
doaj +1 more source
Frontiers in Genetics, 2021 Mycobacterium tuberculosis harbours nine toxin-antitoxin (TA) systems of the MazEF family. MazEF TA modules are of immense importance due to the perceived role of the MazF toxin in M. tuberculosis persistence and disease.
Soumyanetra Chandra +2 more
doaj +1 more source
IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2020 This article presents a personal and critical review of the history of the malate–aspartate shuttle (MAS), starting in 1962 and ending in 2020. The MAS was initially proposed as a route for the oxidation of cytosolic NADH by the mitochondria in Ehrlich ...
P. Borst
semanticscholar +1 more source
The roles of organic acids in C4 photosynthesis
Frontiers in Plant Science, 2016 Organic acids are involved in numerous metabolic pathways in all plants. The finding that some plants, known as C4 plants, have four-carbon dicarboxylic acids as the first product of carbon fixation showed these organic acids play essential roles as ...
Martha eLudwig
doaj +1 more source
Lancet Neurology, 2013 Background Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder in which the use of immunotherapy and the long-term outcome have not been defined.
M. Titulaer +18 more
semanticscholar +1 more source
Inborn disorders of the malate aspartate shuttle
Journal of Inherited Metabolic Disease, 2021 Over the last few years, various inborn disorders have been reported in the malate aspartate shuttle (MAS). The MAS consists of four metabolic enzymes and two transporters, one of them having two isoforms that are expressed in different tissues. Together
M. Broeks +4 more
semanticscholar +1 more source
Plants, 2022 Aspartate is the most critical amino acid in the aspartate metabolic pathway, which is associated with multiple metabolic pathways, such as protein synthesis, nucleotide metabolism, TCA cycle, glycolysis, and hormone biosynthesis. Aspartate also plays an
Shuhan Lei +2 more
doaj +1 more source