Results 11 to 20 of about 467,415 (311)

Aspartate kinase and the synthesis of aspartate-derived amino acids in wheat

Planta, 1978
Aspartate kinase (EC 2.7.2.4.) has been purified from 7 day etiolated wheat (Triticum aestivum L. var. Maris Freeman) seedlings and from embryos imbibed for 8 h. The enzyme was 50% inhibited by 0.25 mM lysine. In this study wheat aspartate kinase was not inhibited by threonine alone or cooperatively with lysine; these results contrast with those ...
Bright, S. W. J., Shewry, P. R., Miflin, B. J.   +2 more
openaire   +3 more sources

An engineered biosensor enables dynamic aspartate measurements in living cells

eLife
Intracellular levels of the amino acid aspartate are responsive to changes in metabolism in mammalian cells and can correspondingly alter cell function, highlighting the need for robust tools to measure aspartate abundance.
Kristian Davidsen, Jonathan S Marvin, Abhi Aggarwal, Timothy A Brown, Lucas B Sullivan   +4 more
doaj   +2 more sources

Aspartate in the Brain: A Review

Neurochemical Research
Abstract l-Aspartate (aspartic acid; C4H7NO4; 2-aminobutanedoic acid) is a non-essential α-amino acid found ubiquitously throughout the body, including in the brain. Aspartate is one of the protein-forming amino acids and the formation of tRNA-aspartate complex is catalysed by aspartyl tRNA synthetase.
Caroline D. Rae, Benjamin D. Rowlands, Vladimir J. Balcar   +2 more
openaire   +4 more sources

Enzyme Nanosheet-Based Electrochemical Aspartate Biosensor for Fish Point-of-Care Applications

Micromachines, 2022
Bacterial infections in marine fishes are linked to mass mortality issues; hence, rapid detection of an infection can contribute to achieving a faster diagnosis using point-of-care testing.
Thenmozhi Rajarathinam, Dinakaran Thirumalai, Sivaguru Jayaraman, Seonghye Kim, Minho Kwon, Hyun-jong Paik, Suhkmann Kim, Mijeong Kang, Seung-Cheol Chang   +8 more
doaj   +1 more source

EPSPs in rat neocortical neurons in vitro. II. Involvement of N-methyl-D-aspartate receptors in the generation of EPSPs [PDF]

, 1989
1. Intracellular recordings were obtained from neurons in layer II/III of rat frontal cortex. Single-electrode current- and voltage-clamp techniques were employed to compare the sensitivity of excitatory postsynaptic potentials (EPSPs) and ...
J. J. Hablitz, Sutor, Bernd, Hablitz, John H., B. Sutor   +3 more
core   +1 more source

Human D-aspartate Oxidase: A Key Player in D-aspartate Metabolism [PDF]

, 2021
In recent years, the D-enantiomers of amino acids have been recognized as natural molecules present in all kingdoms, playing a variety of biological roles.
Giulia Murtas, Gianluca Molla, Molla, Gianluca, Murtas, Giulia, Silvia Sacchi, Sacchi, Silvia, Loredano Pollegioni, Pollegioni, Loredano   +7 more
core   +1 more source

Aspartate metabolic flux promotes nitric oxide to eliminate both antibiotic-sensitive and -resistant Edwardsiella tarda in zebrafish

Frontiers in Immunology, 2023
IntroductionMetabolic reprogramming potentiates host protection against antibiotic-sensitive or -resistant bacteria. However, it remains unclear whether a single reprogramming metabolite is effective enough to combat both antibiotic-sensitive and ...
Jiao Xiang, Min-yi Li, Hui Li, Hui Li, Hui Li, Hui Li   +5 more
doaj   +1 more source

Resource plasticity-driven carbon-nitrogen budgeting enables specialization and division of labor in a clonal community

eLife, 2020
Previously, we found that in glucose-limited Saccharomyces cerevisiae colonies, metabolic constraints drive cells into groups exhibiting gluconeogenic or glycolytic states.
Sriram Varahan, Vaibhhav Sinha, Adhish Walvekar, Sandeep Krishna, Sunil Laxman   +4 more
doaj   +1 more source

An Asp to Strike Out Cancer? Therapeutic Possibilities Arising from Aspartate’s Emerging Roles in Cell Proliferation and Survival

Biomolecules, 2021
A better understanding of the metabolic constraints of a tumor may lead to more effective anticancer treatments. Evidence has emerged in recent years shedding light on a crucial aspartate dependency of many tumor types.
Iiro Taneli Helenius, Hanumantha Rao Madala, Jing-Ruey Joanna Yeh   +2 more
doaj   +1 more source

Chloroquine Triggers Cell Death and Inhibits PARPs in Cell Models of Aggressive Hepatoblastoma

Frontiers in Oncology, 2020
Background: Hepatoblastoma (HB) is the most common pediatric liver malignancy. Despite advances in chemotherapeutic regimens and surgical techniques, the survival of patients with advanced HB remains poor, underscoring the need for new therapeutic ...
Katja Eloranta, Stefano Cairo, Emmi Liljeström, Tea Soini, Tea Soini, Antti Kyrönlahti, Jean-Gabriel Judde, David B. Wilson, David B. Wilson, Markku Heikinheimo, Markku Heikinheimo, Marjut Pihlajoki   +11 more
doaj   +1 more source