Results 31 to 40 of about 572,945 (313)

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumors

Nature Cell Biology, 2018
As oxygen is essential for many metabolic pathways, tumour hypoxia may impair cancer cell proliferation1–4. However, the limiting metabolites for proliferation under hypoxia and in tumours are unknown.
J. Garcia-Bermudez, Lou Baudrier, Konnor C. La, Xiphias Ge Zhu, Justine Fidelin, Vladislav O. Sviderskiy, T. Papagiannakopoulos, H. Molina, M. Snuderl, C. Lewis, Richard L. Possemato, Kıvanç Birsoy   +11 more
semanticscholar   +1 more source

Aspartate aminotransferase and cardiovascular disease—a narrative review

, 2020
This narrative review summarized the existing knowledge on the association between aspartate aminotransferase (AST) and cardiovascular disease (CVD). AST plays a key role in the metabolism of amino acids, maintenance of NAD+/NADH ratio in cells, Krebs ...
G. Ndrepepa
semanticscholar   +1 more source

Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis

Circulation Research, 2019
Supplemental Digital Content is available in the text. Rationale: Hypertrophied hearts switch from mainly using fatty acids (FAs) to an increased reliance on glucose for energy production. It has been shown that preserving FA oxidation (FAO) prevents the
J. Ritterhoff, S. Young, Outi Villet, Dan Shao, Fausto Carnevale Neto, Lisa F Bettcher, Yun-Wei A. Hsu, Stephen C. Kolwicz, D. Raftery, R. Tian   +9 more
semanticscholar   +1 more source

Aspartate is an endogenous metabolic limitation for tumour growth

Nature Cell Biology, 2018
Defining the metabolic limitations of tumour growth will help to develop cancer therapies1. Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that a metabolic limitation may restrict cell proliferation in vivo ...
Lucas B. Sullivan, Alba Luengo, Laura V. Danai, Lauren N. Bush, Frances F. Diehl, Aaron M. Hosios, Allison N. Lau, Sarah Elmiligy, S. Malstrom, C. Lewis, M. V. Vander Heiden   +10 more
semanticscholar   +1 more source

Aspartate aminotransferase Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

Nature Communications, 2020
Gene rv3722c of Mycobacterium tuberculosis is essential for in vitro growth, and encodes a putative pyridoxal phosphate-binding protein of unknown function.
R. Jansen, L. Mandyoli, Ryan Hughes, Shoko Wakabayashi, Jessica T. Pinkham, Bruna P Selbach, Kristine M. Guinn, E. Rubin, J. Sacchettini, K. Rhee   +9 more
semanticscholar   +1 more source

Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells

Cell, 2015
Summary Mitochondrial respiration is important for cell proliferation, however the specific metabolic requirements fulfilled by respiration to support proliferation have not been defined.
Lucas B. Sullivan, D. Y. Gui, Aaron M. Hosios, Lauren N. Bush, Elizaveta Freinkman, M. V. Vander Heiden   +5 more
semanticscholar   +1 more source

Antidepressant Effect of Shaded White Leaf Tea Containing High Levels of Caffeine and Amino Acids

Molecules, 2020
The young leaves of green tea become lighter in color than usual when protected from sunlight by a shading net for about two weeks while growing. These leaves are called “shaded white leaf tea” or SWLT.
Keiko Unno, Daisuke Furushima, Yuzuki Nomura, Hiroshi Yamada, Kazuaki Iguchi, Kyoko Taguchi, Toshikazu Suzuki, Makoto Ozeki, Yoriyuki Nakamura   +8 more
doaj   +1 more source

Sitting Interruption Modalities during Prolonged Sitting Acutely Improve Postprandial Metabolome in a Crossover Pilot Trial among Postmenopausal Women

Metabolites
Older adults sit during most hours of the day; more than 30% are considered physically inactive. The accumulation of prolonged sitting time is an exercise-independent risk factor for aging-related conditions such as cardiometabolic disease and cancer ...
Jeffrey S. Patterson, Brinda K. Rana, Haiwei Gu, Dorothy D. Sears   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source