Results 51 to 60 of about 499,523 (302)

Selective Plasmatic Amino Acid Alterations as a Potential Biomarker for Pathological Stratification in Autism Spectrum Disorders

Biomedicines
Background: Autism Spectrum Disorders (ASD) are neurodevelopmental disorders characterized by repetitive behaviors and social interaction deficits. While the severity of ASD is classified into levels (1–3) by the DSM-5, reliable circulating biomarkers to
Andrea De Giacomo, Nicoletta Lionetti, Maria Grazia Di Lago, Simonetta Simonetti, Giulia Iapadre, Alessandro Rizzello, Vittorio Sanginario, Federica Gradia, Donatella Tansella, Eustachio Vitullo, Marta Simone, Dario Sardella, Tania Lorè, Roberta Cardinali, Silvia Russo, Vincenzo Salpietro, Salvatore Scacco, Maurizio Delvecchio, Antonio Gnoni   +18 more
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Regulación de la utilización del aspartato por los astrocitos durante la prelactancia

Universitas Scientiarum, 2009
Regulation of the use of aspartate by the astrocytes during the presuckling period. During the perinatal period the concentration ofN-acetyl-L-aspartate (NAA) produced by neurons increases.
Cecilia Espíndola, Ludis Morales, María Juliana Salamanca Ortiz, Jairo Alfonso Tovar-Franco   +3 more
doaj  

An engineered biosensor enables dynamic aspartate measurements in living cells

eLife
Intracellular levels of the amino acid aspartate are responsive to changes in metabolism in mammalian cells and can correspondingly alter cell function, highlighting the need for robust tools to measure aspartate abundance.
Kristian Davidsen, Jonathan S Marvin, Abhi Aggarwal, Timothy A Brown, Lucas B Sullivan   +4 more
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Differences in ureide and amino acid content of water stressed soybean inoculated with Bradyrhizobium japonicum and B. elkanii Alterações na concentração de ureídos e aminoácidos em soja sob estresse hídrico com inoculação de Bradyrhizobium japonicum e B. elkanii

Pesquisa Agropecuária Brasileira, 2005
The objective of this work was to study the response to water stress of a drought sensitive soybean cultivar inoculated with Bradyrhizobium japonicum (strain CB1809, Semia 586) and B. elkanii (strain 29W, Semia 5019).
Maria Lucrecia Gerosa Ramos, Richard Parsons, Janet Irene Sprent   +2 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

THE EFFECT OF SINGLE COMPLEX INTOXICATION WITH MORPHINE AND ALCOHOL ON THE CONTENT OF NEUROACTIVE AMINO ACIDS IN THE BRAIN OF RATS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Background. Cases of combined consumption of surfactants (alcohol and opiates) in both the adult population and adolescents are quite common at present.
Velichko I. M., Lelevich S. V., Lelevich V. V.   +2 more
doaj   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Acylation of aspartate aminotransferase [PDF]

Biochemical Journal, 1967
1. Acetylation of aspartate aminotransferase from pig heart inhibits completely the enzymic activity when the coenzyme is in the amino form (pyridoxamine phosphate) or when the coenzyme has been removed, but not when the coenzyme is in the aldehyde form (pyridoxal phosphate). 2.
C, Turano, A, Giartosio, F, Riva, V, Baroncelli   +3 more
openaire   +2 more sources