Results 51 to 60 of about 572,945 (313)

Selective Plasmatic Amino Acid Alterations as a Potential Biomarker for Pathological Stratification in Autism Spectrum Disorders

Biomedicines
Background: Autism Spectrum Disorders (ASD) are neurodevelopmental disorders characterized by repetitive behaviors and social interaction deficits. While the severity of ASD is classified into levels (1–3) by the DSM-5, reliable circulating biomarkers to
Andrea De Giacomo, Nicoletta Lionetti, Maria Grazia Di Lago, Simonetta Simonetti, Giulia Iapadre, Alessandro Rizzello, Vittorio Sanginario, Federica Gradia, Donatella Tansella, Eustachio Vitullo, Marta Simone, Dario Sardella, Tania Lorè, Roberta Cardinali, Silvia Russo, Vincenzo Salpietro, Salvatore Scacco, Maurizio Delvecchio, Antonio Gnoni   +18 more
doaj   +1 more source

Uncoupling Protein 3 Catalyzes the Exchange of C4 Metabolites Similar to UCP2

Biomolecules, 2023
Uncoupling protein 3 (UCP3) belongs to the mitochondrial carrier protein superfamily SLC25 and is abundant in brown adipose tissue (BAT), the heart, and muscles.
Jürgen Kreiter, Tatyana Tyschuk, Elena E. Pohl   +2 more
doaj   +1 more source

Acylation of aspartate aminotransferase [PDF]

Biochemical Journal, 1967
1. Acetylation of aspartate aminotransferase from pig heart inhibits completely the enzymic activity when the coenzyme is in the amino form (pyridoxamine phosphate) or when the coenzyme has been removed, but not when the coenzyme is in the aldehyde form (pyridoxal phosphate). 2.
C, Turano, A, Giartosio, F, Riva, V, Baroncelli   +3 more
openaire   +2 more sources

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Regulación de la utilización del aspartato por los astrocitos durante la prelactancia

Universitas Scientiarum, 2009
Regulation of the use of aspartate by the astrocytes during the presuckling period. During the perinatal period the concentration ofN-acetyl-L-aspartate (NAA) produced by neurons increases.
Cecilia Espíndola, Ludis Morales, María Juliana Salamanca Ortiz, Jairo Alfonso Tovar-Franco   +3 more
doaj  

An engineered biosensor enables dynamic aspartate measurements in living cells

eLife
Intracellular levels of the amino acid aspartate are responsive to changes in metabolism in mammalian cells and can correspondingly alter cell function, highlighting the need for robust tools to measure aspartate abundance.
Kristian Davidsen, Jonathan S Marvin, Abhi Aggarwal, Timothy A Brown, Lucas B Sullivan   +4 more
doaj   +1 more source

Pyrazinamide triggers degradation of its target aspartate decarboxylase

Nature Communications, 2019
Pyrazinamide is a sterilizing first-line tuberculosis drug. Genetic, metabolomic and biophysical analyses previously demonstrated that pyrazinoic acid, the bioactive form of the prodrug pyrazinamide (PZA), interrupts biosynthesis of coenzyme A in ...
Pooja Gopal, J. Sarathy, Michelle Yee, P. Ragunathan, Joon Shin, S. Bhushan, Junhao Zhu, T. Akopian, Olga Kandror, T. Lim, M. Gengenbacher, Q. Lin, E. Rubin, G. Grueber, T. Dick   +14 more
semanticscholar   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Differences in ureide and amino acid content of water stressed soybean inoculated with Bradyrhizobium japonicum and B. elkanii Alterações na concentração de ureídos e aminoácidos em soja sob estresse hídrico com inoculação de Bradyrhizobium japonicum e B. elkanii

Pesquisa Agropecuária Brasileira, 2005
The objective of this work was to study the response to water stress of a drought sensitive soybean cultivar inoculated with Bradyrhizobium japonicum (strain CB1809, Semia 586) and B. elkanii (strain 29W, Semia 5019).
Maria Lucrecia Gerosa Ramos, Richard Parsons, Janet Irene Sprent   +2 more
doaj   +1 more source

Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction

Communications Biology, 2018
Defective arginine synthesis, due to the silencing of argininosuccinate synthase 1 (ASS1), is a common metabolic vulnerability in cancer, known as arginine auxotrophy.
Chun-Ting Cheng, Y. Qi, Yi Wang, Kevin K. Chi, Yiyin Chung, C. Ouyang, Yun-Ru Chen, M. Oh, Xiangpeng Sheng, Yulong Tang, Yun Liu, H. H. Lin, Ching-Ying Kuo, Dustin E. Schones, Christina M. Vidal, Jennyfer Milagros Chumacero Chu, Hung-Jung Wang, Y. Chen, K. Miller, P. Chu, Y. Yen, Lei Jiang, Hsing Jien Kung, Hsing Jien Kung, D. Ann   +24 more
semanticscholar   +1 more source