Results 61 to 70 of about 572,945 (313)

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

THE EFFECT OF SINGLE COMPLEX INTOXICATION WITH MORPHINE AND ALCOHOL ON THE CONTENT OF NEUROACTIVE AMINO ACIDS IN THE BRAIN OF RATS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2020
Background. Cases of combined consumption of surfactants (alcohol and opiates) in both the adult population and adolescents are quite common at present.
Velichko I. M., Lelevich S. V., Lelevich V. V.   +2 more
doaj   +1 more source

HIF1α Suppresses Tumor Cell Proliferation through Inhibition of Aspartate Biosynthesis.

Cell Reports, 2019
Cellular aspartate drives cancer cell proliferation, but signaling pathways that rewire aspartate biosynthesis to control cell growth remain largely unknown. Hypoxia-inducible factor-1α (HIF1α) can suppress tumor cell proliferation.
Florinda Meléndez-Rodríguez, Andrés A. Urrutia, Doriane Lorendeau, Gianmarco Rinaldi, O. Roche, Nuray Bögürcü-Seidel, Marta Ortega Muelas, Claudia Mesa-Ciller, Guillermo Turiel, Antonio Bouthelier, P. Hernansanz-Agustín, Ainara Elorza, E. Escasany, Q. Li, Mar Torres-Capelli, Daniel Tello, E. Fuertes, Enrique Fraga, A. Martínez-Ruíz, Belén Pérez, J. M. Giménez-Bachs, A. S. Salinas-Sánchez, T. Acker, Ricardo Sánchez Prieto, S. Fendt, K. de Bock, Julián Aragonés   +26 more
semanticscholar   +1 more source

FDG‐PET Associations With Disease Severity and Outcomes in NMDA‐Receptor IgG Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Patients with N‐methyl‐D‐aspartate (NMDA) receptor‐immunoglobulin G (IgG) autoimmune encephalitis (NMDAR‐IgG AE) demonstrate occipital lobe hypometabolism on baseline brain fluorodeoxyglucose‐positron emission tomography (bFDG‐PET).
Jonathan K. Lee, Jeffrey Lambe, Scott Johnson, Akua Abrah, Jennifer Bullen, Jeffrey A. Cohen, Tatchaporn Ongphichetmetha, Amy Kunchok   +7 more
wiley   +1 more source

Loss of Carbamoyl Phosphate Synthetase 1 Potentiates Hepatocellular Carcinoma Metastasis by Reducing Aspartate Level

Advanced Science
Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Numerous studies have shown that metabolic reprogramming is crucial for the development of HCC. Carbamoyl phosphate synthase 1 (CPS1), a rate‐limiting enzyme in urea cycle, is an
Siyuan Chen, Qin Tang, Manqiu Hu, Sijie Song, Xiaohong Wu, You Zhou, Zihan Yang, Siqi Liao, Li Zhou, Qingliang Wang, Hongtao Liu, Mengsu Yang, Zhe‐Sheng Chen, Wei Zhao, Song He, Zhihang Zhou   +15 more
doaj   +1 more source

Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

Nature Communications, 2019
A major constraint for developing new anti-tuberculosis drugs is the limited number of validated targets that allow eradication of persistent infections.
Erik J Hasenoehrl, Dannah Rae Sajorda, Linda Berney-Meyer, Samantha T. Johnson, J. Tufariello, Tobias Fuhrer, G. Cook, W. Jacobs, Michael Berney   +8 more
semanticscholar   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

The Role of Hyperemesis Gravidarum in the First-Trimester as a Predictor of Intrahepatic Cholestasis of Pregnancy

Clinical and Experimental Obstetrics & Gynecology
Background: Intrahepatic cholestasis of pregnancy (ICP) and hyperemesis gravidarum (HEG) are pregnancy-specific liver diseases associated with significant fetal and maternal complications.
Ayça Kubat Küçükyurt, Selma Atiye Kolcu   +1 more
doaj   +1 more source

Anti-fibrotic effects of Cuscuta chinensis with in vitro hepatic stellate cells and a thioacetamide-induced experimental rat model

Pharmaceutical Biology, 2017
Context: Cuscuta chinensis Lam. (Convolvulaceae) has been used as a traditional herbal remedy for treating liver and kidney disorders. Objective: Anti-fibrotic effects of C.
Jin Seoub Kim, Sushruta Koppula, Mun Jeong Yum, Gwang Mo Shin, Yun Jin Chae, Seok Min Hong, Jae Dong Lee, MinDong Song   +7 more
doaj   +1 more source

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source