Results 61 to 70 of about 467,415 (311)

Recurrent Hypothermia and Autonomic Dysfunction Secondary to Shapiro Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 44‐year‐old man presented with recurrent hypothermia, diaphoresis and hypertension. Extensive investigation for infectious, inflammatory, metabolic and endocrine aetiologies was negative. MR scan of the brain demonstrated no lesions but revealed callosal dysgenesis, consistent with Shapiro syndrome.
Naveen Kumar, Jeremy Johnson, Susanne Watkins, Eoin Mulroy   +3 more
wiley   +1 more source

Eliminating Assay Background of a Low-Cost, Colorimetric Glutamine Biosensor by Engineering an Alternative Formulation of Cell-Free Protein Synthesis

Chemosensors
Glutamine is an essential biomolecule that plays a pivotal role in many diseases, such as cancer, where it can serve as fuel for rapid proliferation. Treatments for these diseases can be monitored and optimized through the detection of glutamine, though ...
Joseph P. Talley, Tyler J. Free, Tyler P. Green, Dallin M. Chipman, Bradley C. Bundy   +4 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

D-aspartate and NMDA, but not L-aspartate, block AMPA receptors in rat hippocampal neurons

, 2005
Udgivelsesdato: 2005-Jun1 The amino acid, D-aspartate, exists in the mammalian brain and is an agonist at the N-methyl-D-aspartate (NMDA) subtype of ionotropic glutamate receptors.
Pickering, Darryl, Zabek, Rebecca L, Bai, Donglin, Lu, Wei-Yang, Gong, Xiang-Qun, Xiang-Qun Gong, Anne Frandsen, Wei-Yang Lu, Rebecca L Zabek, Donglin Bai, Frandsen, Anne, Yudi Wan, Wan, Yudi, Darryl S Pickering   +13 more
core   +1 more source

Photoinactivation of Aspartate Aminotransferase

Journal of Biological Chemistry, 1970
Abstract The cofactor pyridoxal 5'-phosphate bound through an aldimine linkage to lysine residues of the enzyme aspartate aminotransferase is very stable to irradiation with light of 420 nm. The catalytic function of the enzyme exposed to light absorbed by the cofactor remains unaffected, indicating that pyridoxal 5'-phosphate is not an efficient ...
N, Burridge, J E, Churchich
openaire   +2 more sources

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Respiratory Supercomplexes Promote Mitochondrial Efficiency and Growth in Severely Hypoxic Pancreatic Cancer

Cell Reports, 2020
Summary: Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive fibrosis and hypovascularization, resulting in significant intratumoral hypoxia (low oxygen) that contributes to its aggressiveness, therapeutic resistance, and high mortality.
Kate E.R. Hollinshead, Seth J. Parker, Vinay V. Eapen, Joel Encarnacion-Rosado, Albert Sohn, Tugba Oncu, Michael Cammer, Joseph D. Mancias, Alec C. Kimmelman   +8 more
doaj   +1 more source

The Structure and Properties of Copolyaspartate II. Copoly(ethyl-L-aspartate-benzyl-L-aspartate) and Copoly(methyl-L-aspartate-benzyl-L-aspartate) [PDF]

Polymer Journal, 1982
The Structure and Properties of Copolyaspartate II. Copoly(ethyl- L -aspartate-benzyl- L -aspartate) and Copoly(methyl- L -aspartate-benzyl- L -aspartate)
Tsujita, Yoshiharu, Fukagawa, Mikio, Uematsu, Ichitaro   +2 more
openaire   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels [PDF]

, 2006
It is known that glutamatergic and cholinergic systems interact functionally at the level of the cholinergic basal forebrain. The N-methyl-D-aspartate receptor (NMDA-R) is a multiprotein complex composed of NR1, NR2 and/or NR3 subunits.
Dolga, A.,, Eisel, U.L.M.,, Dolga, Amalia, Dere, E., I. Pieri, L. Marchetti, Dere, E.,, Pieri, I., Marchetti, L., De Souza Silva, M. A., Huston, J. P., Marchetti, L.,, A. Dolga, J. P. Huston, Dolga, Amalia; id_orcid, U. L. M. Eisel, Huston, J.P.,, Pieri, I.,, Eisel, U. L. M., Souza Silva, M.A. De,, E. Dere, M. A. De Souza Silva, Eisel, U. L. M.; id_orcid   +22 more
core   +1 more source