Results 71 to 80 of about 499,523 (302)
Cholinergic cells in the nucleus basalis of mice express the N-methyl-D-aspartate-receptor subunit NR2C and its replacement by the NR2B subunit enhances frontal and amygdaloid acetylcholine levels [PDF]
, 2006 It is known that glutamatergic and cholinergic systems interact functionally at the level of the cholinergic basal forebrain. The N-methyl-D-aspartate receptor (NMDA-R) is a multiprotein complex composed of NR1, NR2 and/or NR3 subunits.
Dolga, A., +22 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel +6 more
wiley +1 more source
Presence of Aspartate Aminotransferase in peri-implant crevicular fluid with and without mucositis
, 2012 © 2012 American Academy of Implant Dentistry. This document is the Published version of a Published Work that appeared in final form in Journal of Oral Implantology (JOI). To access the final edited and published work see https://doi.org/10.1563/AAID-JOI-
Sánchez-Pérez, Arturo +2 more
core +1 more source
, 2018 ObjectiveDespite the serious neurodevelopmental sequelae of epileptic encephalopathy during infancy, the pathomechanisms involved remain unclear. To find potential biomarkers that can reflect the pathogenesis of epileptic encephalopathy, we explored the ...
Mi-Sun Yum (5104079) +5 more
core +1 more source
Covalent flavinylation of L-aspartate oxidase from Escherichia coli using N6-(6-carboxyhexyl)-FAD succinidoester [PDF]
, 1999 L-Aspartate oxidase is a flavoprotein catalyzing the first step in the de novo biosynthesis of pyridine nucleotides in E. coli. Binding of FAD to L- aspartate oxidase is relatively weak (K(d) 6.7 x 10-7 M), resulting in partial loss of the coenzyme under
C. Treu +13 more
core +1 more source
Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells
Molecular & Cellular Oncology, 2019 Cancer cells rely on glutamine to fuel mitochondria, however it remains unclear whether this is needed for bioenergetic or biosynthetic pathways. Our study suggests that an essential function of mitochondrial glutamine metabolism is to provide aspartate ...
H. Furkan Alkan +1 more
doaj +1 more source
Mitochondrial Regulation of the 26S Proteasome
Cell Reports, 2020 Summary: The proteasome is the main proteolytic system for targeted protein degradation in the cell and is fine-tuned according to cellular needs.
Thomas Meul +23 more
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko +4 more
wiley +1 more source
In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]
, 2008 N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien +4 more
core
, 2018 ObjectiveDespite the serious neurodevelopmental sequelae of epileptic encephalopathy during infancy, the pathomechanisms involved remain unclear. To find potential biomarkers that can reflect the pathogenesis of epileptic encephalopathy, we explored the ...
Mi-Sun Yum (5104079) +5 more
core +1 more source