Results 241 to 250 of about 897,077 (404)

Targeted STING Activation Using Modified Ultrasound‐Responsive Microbubbles Enhances Immune Checkpoint Blockade Against Melanoma

Advanced Science, EarlyView.
This study explores the use of ultrasound contrast agents loaded with Stimulator of Interferon Genes (STING) agonists as an approach to activate the body's immune system against cancer. Termed Microbubble‐assisted UltraSound‐guided Immunotherapy of Cancer (MUSIC), this strategy effectively inhibits tumor growth and improves survival in mouse models of ...
Sina Khorsandi, Kristin Huntoon, Yifan Wang, Adam Woodward, Abin Antony, Connor Endsley, Nazia Hafeez, Jared L. Edwards, Nicole McCuen, Prasanna G. Alluri, Betty Y.S. Kim, Wen Jiang, Jacques Lux   +12 more
wiley   +1 more source

Biocatalytic reductive amination with CRISPR-Cas9 engineered yeast. [PDF]

Sci Rep
Hagman A, Stenström O, Carlström G, Akke M, Grey C, Carlquist M.   +5 more
europepmc   +1 more source

Mitochondrial defects associated with β-alanine toxicity: relevance to hyper-beta-alaninemia

Molecular and Cellular Biochemistry, 2016
A. Shetewy, K. Shimada-Takaura, Danielle Warner, C. J. Jong, Abu-Bakr Al Mehdi, M. Alexeyev, Kyoko Takahashi, S. Schaffer   +7 more
semanticscholar   +1 more source

An Engineered PfAgo with Wide Catalytic Temperature Range and Substrate Spectrum

Advanced Science, EarlyView.
This work presents a strategy for engineering thermophilic Ago proteins to obtain wide catalytic temperature range and broad substrate spectrum. This strategy is applied to engineer PfAgo and TtdAgo, and the biochemical properties of the engineered PfAgo are systematically characterized. The study further elucidates the structural differences involved.
Longyu Wang, Xiaochen Xie, Fuyong Huang, Qiang Wei, Tianxin Cai, Na Yu, Shi Chen, Fei Wang, Wanping Chen, Chin‐yu Chen, Chunhua Li, Lixin Ma   +11 more
wiley   +1 more source

Structural Modelling of Krüppel-Like Factor 15 Zinc Finger Binding Domain to DNA Using AlphaFold 3.0: Potential Therapeutic Target for Type 2 Diabetes. [PDF]

J Cell Mol Med
Mohammad A, Abubaker J, Marafie SK, AlShawaf E, Ali H, Al-Mulla F.   +5 more
europepmc   +1 more source

METTL14‐Induced M6A Methylation Increases G6pc Biosynthesis, Hepatic Glucose Production and Metabolic Disorders in Obesity

Advanced Science, EarlyView.
It is shown that obesity is associated with increases in hepatic METTL14 and m6A methylation of G6pc transcript. YTHDF1 and YTHDF3 bind to m6A‐marked G6pc mRNA to increase its synthesis. Hepatocyte‐specific deletion of Mettl14 decreases G6pc m6A methylation, G6pc biosynthesis, and G6pc‐mediated gluconeogenesis, alleviating glucose metabolic defects in ...
Qiantao Zheng, Xiao Zhong, Qianqian Kang, Zhiguo Zhang, Decheng Ren, Yong Liu, Liangyou Rui   +6 more
wiley   +1 more source

The homeostasis of β-alanine is key for Arabidopsis reproductive growth and development. [PDF]

Plant J
Wu S, Zhang Y, Luzarowska U, Yang L, Salem MA, Thirumalaikumar VP, Sade N, Galperin VE, Fernie A, Sampathkumar A, Bershtein S, Fusari CM, Brotman Y.   +12 more
europepmc   +1 more source

The crystal structure ofL-alanine [PDF]

, 1966
Harold Simpson, R.E. Marsh
openalex   +1 more source

Inhalable Polymeric Nanoparticle Containing Triphenylphosphanium Bromide‐modified Sonosensitizer for Enhanced Therapy of Acute Bacterial Pneumonia

Advanced Science, EarlyView.
Bacterial pneumonia is the sixth leading cause of death. In this study, an inhalable polymeric nanoparticle NPFCPS‐P is developed, which under US stimulation showed high efficacy in the treatment of acute bacterial pneumonia. This nanoplatform would be much less prone to select bacterial resistance and represented a promising measure for antibiotics ...
Lin Wang, Fangzhou Chen, Nier Wu, Lingfei Hu, Haihua Xiao, Hanchen Zhang, Dongsheng Zhou   +6 more
wiley   +1 more source

d-Alanine, a Circadian Metabolite that Regulates Glucose Metabolism and Viral Infection. [PDF]

Chembiochem
Kimura T, Sakai S, Isaka Y.
europepmc   +1 more source