Results 251 to 260 of about 814,837 (335)

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

Uncovering Major Structural and Functional Features of Methyl-Coenzyme M Reductase (MCR) from <i>Methanobrevibacter ruminantium</i> in Complex with Two Substrates. [PDF]

Int J Mol Sci
Chai HH, Park W, Lim D.
europepmc   +1 more source

The effect of L-carnosine, D-carnosine, L-histidine and β-alanine on the specific growth rate and viability of yeast cultures grown on fermentable (glucose) and non-fermentable (glycerol) carbon sources.

, 2015
P. Cartwright Stephanie, Bill Roslyn M., R. Hipkiss Alan   +2 more
openalex   +2 more sources

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Electron and proton FLASH beam dosimetry using unified alanine, EBT-XD, and HD-V2 Gafchromic film dosimeters. [PDF]

Med Phys
Jung S, Kim IJ, Yi CY, Kim YH, Seong YM, Solomon R, Choi SH, Jang YJ, Lee SB, Kim CE, Pak SI, Park JI.   +11 more
europepmc   +1 more source

DL-Alanine [PDF]

, 2020
openaire   +1 more source

Resonant Raman Scattering and Optical Absorption Studies of Zn(II) Impurities in L-Alanine Single Crystal [PDF]

A. Nonato, Gabriel Teles, C.C. Silva, Rosivaldo Xavier da Silva, Juan S. Rodríguez-Hernández, C. W. A. Paschoal, Alan Silva de Menezes, Clenilton Costa dos Santos   +7 more
openalex   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

Advanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng, Zongbi Yi, Jing Hu, Jiali Li, Yu Xu, Xiuli Guo, Qian Ji, Kaixiang Feng, Ying Zhang, Sirui Bai, Yushuang Tan, Yufei Yan, Linzhi Han, Jing Jiang, Tengfei Wang, Xiang Wang, Ziqing Zhan, Ruiying Huang, Jinfang Zhang, Conghua Xie, Binghe Xu   +20 more
wiley   +1 more source

Structural mapping of NTCP distinguishes its dual functionality as a hepatitis B virus receptor and bile acid transporter. [PDF]

PLoS Pathog
Matsuzawa K, Ekimoto T, Kobayashi C, Shionoya K, Mifune J, Morita T, Takeuchi JS, Park SY, Ikeguchi M, Sureau C, Kawaguchi A, Watashi K.   +11 more
europepmc   +1 more source

Acidic Residues Important for Substrate Binding and Cofactor Reactivity in Eukaryotic Ornithine Decarboxylase Identified by Alanine Scanning Mutagenesis

, 1995
Andrei L. Osterman, Lisa N. Kinch, Nick V. Grishin, Margaret A. Phillips   +3 more
openalex   +1 more source