Results 251 to 260 of about 897,077 (404)

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Advanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang   +15 more
wiley   +1 more source

Amino Acid Electrosynthesis with Oxygen Vacancy-Mediated CeO₂ Nanocrystals: Facet Effect and Catalytic Mechanism. [PDF]

JACS Au
Shao J, Wang JH, Zhang YF, Xue SZ, Dong H, Liu HC, Li C, Zhang YW.   +7 more
europepmc   +1 more source

β-Alanine as an Ethylene Precursor. Investigations Towards Preparation, and Properties, of a Soluble Enzyme System From a Subcellular Particulate Fraction of Bean Cotyledons [PDF]

, 1969
Robert A. Stinson, Mary E. Spencer
openalex   +1 more source

Chimeric Nanozyme Bacterial Outer Membrane Vesicles Reprograming Tumor Microenvironment for Safe and Efficient Anticancer Therapy

Advanced Science, EarlyView.
This study reports an innovative strategy to improve the safety of OMVs by shielding them with a sophisticated shell composed of DaFe shell and Au nanoparticles, which not only reduces the toxicity of OMVs during circulation but also enables rapid release of these therapeutically active components in tumor for combined therapy involving glucose ...
Fan Zhang, Qianqian Li, Haibing Dai, Weiqun Li, Xiang Chen, Huibin Wu, Shanming Lu, Ran Luo, Feng Li, Guihong Lu, Jianbo Yu, Lin Mei   +11 more
wiley   +1 more source

Elucidation of short linear motif-based interactions of the MIT and rhodanese domains of the ubiquitin-specific protease 8. [PDF]

Biol Direct
Konstantinou A, Varga JK, Córdova-Pérez A, Simonetti L, Gomez-Lucas L, Schueler-Furman O, Davey NE, Kulathu Y, Ivarsson Y.   +8 more
europepmc   +1 more source

Density functional theory as a tool for the structure determination of radiation-induced bioradicals [PDF]

, 2004
DE PROFT, F, GEERLINGS, P, LAHORTE, P, Pauwels, Ewald, Van Speybroeck, Veronique, Waroquier, Michel   +5 more
core   +1 more source

On the influence of the oral administration of DL-Alanine on the acidity of gastric juice

, 1955
Yugo Aoshima
openalex   +2 more sources

Inhibitors of alanine racemase enzyme: a review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2015
M. Azam, U. Jayaram
semanticscholar   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

Advanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang, Lixia Song, Rui Fan, Qianqian Chen, Ruisheng Fu, Mei You, Yuxiao Wu, Meng Cai, Yong Li, Meihong Xu   +9 more
wiley   +1 more source

Discovery of novel DdlA inhibitors in multidrug-resistant Pseudomonas aeruginosa using virtual screening, molecular docking, and dynamics simulations. [PDF]

Sci Rep
Aldakheel FM, Alduraywish SA.
europepmc   +1 more source