Paralogous ALT1 and ALT2 retention and diversification have generated catalytically active and inactive aminotransferases in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2012 BACKGROUND: Gene duplication and the subsequent divergence of paralogous pairs play a central role in the evolution of novel gene functions. S. cerevisiae possesses two paralogous genes (ALT1/ALT2) which presumably encode alanine aminotransferases.
Georgina Peñalosa-Ruiz +5 more
doaj +1 more source
Lactate Dehydrogenase and Hepatic Transaminases as Prognostic Markers of Hypoxic Ischaemic Encephalopathy in Neonates with Perinatal Asphyxia [PDF]
Indian Journal of Neonatal Medicine and Research, 2020 Introduction: Hypoxic Ischaemic Encephalopathy (HIE) following perinatal asphyxia, due to cerebral hypoxia is an important cause of neonatal morbidly and mortality. Hypoxia causes cell death in various tissues like liver, kidney and muscles also.
VIJAYAKUMAR BALAKRISHNAN +3 more
doaj +1 more source
Correlation between Aspartate Aminotransferase/Alanine Aminotransferase and Prognosis of Hemophagocytic Lymphohistiocytosis in Children [PDF]
Zhongguo quanke yixue, 2023 Background Aspartate aminotransferase (AST) /alanine aminotransferase (ALT) is a novel indicator to evaluate the prognosis of acute critical illness in recent years.
SHI Xiaoqi, LUO Nandu, HUANG Jiaojiao, DU Zuochen, HUANG Pei, CAO Xiuli, CHEN Yan, HE Zhixu
doaj +1 more source
Korean Journal of Clinical Laboratory Science, 2021 The present study was conducted to assess the relationship between aspartate aminotransferase/ alanine aminotransferase (AST/ALT) ratio and pulse pressure in Korean adults with hypertension.
Hyun Yoon
doaj +1 more source
Simultaneus effect of aerobic training and garlic supplementation on resting levels serum of amino transferases in obese men [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2020 Background: Obesity is a risk factor for several diseases including metabolic and cardiovascular diseases and is underlying cause of liver diseases. Researches indicate that life style modification via changes in physical activity levels and healthy diet
Pejhman Zahedi +2 more
doaj +1 more source
Serum γ-glutamyltransferase, alanine aminotransferase and aspartate aminotransferase activity in healthy blood donor of different ethnic groups in Gorgan [PDF]
, 2016 Introduction: Measure of liver enzymes may help to increase safety of blood donation for both blood donor and recipient. Determination of liver enzymes may prepare valuable clinical information.
Marjani, A. +2 more
core +1 more source
Nonalcoholic steatohepatitis pharmacotherapy and predictors of response: dual role of aminotransferases as biosensors of metabolism and biomarkers of histological improvement [PDF]
, 2019 Nonalcoholic steatohepatitis (NASH)—the severe histological form of nonalcoholic fatty liver disease (NAFLD)—is regarded as a major health problem worldwide (1,2).
Pirola, Carlos José +1 more
core +1 more source
Empagliflozin is associated with improvements in liver enzymes potentially consistent with reductions in liver fat: results from randomised trials including the EMPA-REG OUTCOME® trial [PDF]
, 2018 Aims/hypothesis: In addition to beneficial effects on glycaemia and cardiovascular death, empagliflozin improves adiposity indices. We investigated the effect of empagliflozin on aminotransferases (correlates of liver fat) in individuals with type 2 ...
Fitchett, David +4 more
core +1 more source
Nevirapine versus Efavirenz for patients co-infected with HIV and Tuberculosis: A Randomised Non-Inferiority Trial [PDF]
, 2013 BACKGROUND: In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-
Agnès Sobry +39 more
core +3 more sources
The effect of 12 weeks regular physical activity and vitamin E in the treatment of non-alcoholic steatohepatitis: A pilot study [PDF]
, 2015 Background: Despite the prevalence of Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH), there was no treatment has been proven to be effective in these common diseases.
Eslami, L. +5 more
core +7 more sources