Results 211 to 220 of about 457,916 (395)
Chronic hepatitis in United Kingdom blood donors infected with hepatitis C virus [PDF]
Irving, W L+4 more
core +1 more source
Chronic Infection with Hepatitis C Virus in Patients with Elevated or Persistently Normal Serum Alanine Aminotransferase Levels: Comparison of Hepatic Histology and Response to Interferon Therapy [PDF]
Mitchell L. Shiffman+6 more
openalex +1 more source
This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv+8 more
wiley +1 more source
Molecular Adaptation of Alanine : Glyoxylate Aminotransferase Targeting in Primates [PDF]
Joanna D. Holbrook+4 more
openalex +1 more source
The complex centered on Ghd7 binds to numerous carbon and nitrogen metabolism genes on the genome through the corresponding motifs and transactivates the transcriptional expression of these carbon and nitrogen metabolism genes. With the assistance of OsNAC42 and other unknown Ghd7‐interacting proteins, this complex can regulate different metabolic ...
Guangming Lou+23 more
wiley +1 more source
Macrophage GHSR‐Foxo1 axis regulates CCl4‐induced liver fibrosis by promoting inflammation and TGF‐β1‐mediated HSC activation. GHSR activates PKA‐dependent phosphorylation of Foxo1 at serine 273, promoting macrophage pro‐inflammatory polarization to enhance the production of pro‐inflammatory cytokines that damage hepatocytes, thereby inducing liver ...
Da Mi Kim+9 more
wiley +1 more source
Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu+9 more
wiley +1 more source
FORT: Forward-Only Regression Training of Normalizing Flows [PDF]
Simulation-free training frameworks have been at the forefront of the generative modelling revolution in continuous spaces, leading to neural dynamical systems that encompass modern large-scale diffusion and flow matching models. Despite the scalability of training, the generation of high-quality samples and their corresponding likelihood under the ...
arxiv