Results 51 to 60 of about 297,769 (330)

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Association of Alanine Aminotransferase and Periodontitis: A Cross-Sectional Analysis—NHANES 2009–2012

International Journal of Inflammation, 2016
Objective. Alanine Aminotransferase is an enzyme associated with not only liver diseases, liver conditions, and metabolic syndrome, but also inflammation. Periodontitis is associated with increased cytokines and other markers of inflammation. The purpose
R. Constance Wiener, Usha Sambamoorthi, Richard J. Jurevic   +2 more
doaj   +1 more source

Indirect treatment comparison of dabrafenib plus trametinib versus vemurafenib plus cobimetinib in previously untreated metastatic melanoma patients. [PDF]

, 2017
BackgroundMetastatic melanoma is an aggressive form of skin cancer with a high mortality rate and the fastest growing global incidence rate of all malignancies.
Ahuja, Amit, Chen, Lei, Daud, Adil, Gill, Japinder, Kamra, Sheily   +4 more
core   +2 more sources

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

The Interactions between Metallic Nanoparticles and Cytochrome P450, Alanine Aminotransferase, and Aspartate Aminotransferase Enzymes

Journal of Pure and Applied Microbiology, 2023
The use of metallic nanoparticles (NPs) in various industrial and biomedical fields is increasing exponentially. As a result, research examining the potentially toxic impact of these NPs on human health is also increasing. Cytochrome P450 (P450s) enzymes
Hayat A. Al-Btoush
doaj   +1 more source

Perbedaan Kadar Alanine Aminotransferase (Alt) Dalam Serum Dari Darah Yang Disentrifugasi Pada Kecepatan 3000 Rpm Selama 5 Menit Dan 4400 Rpm Selama 3 Menit [PDF]

, 2019
Background : Laboratory tests for liver and heart are emergency, so the examination must be carried out quickly including ALT examination. One way is by reducing the time of centrifugation without reducing the quality of serum.
.,, Suryani
core  

Assessing Non-Invasive Liver Function in Patients With Intestinal Failure Receiving Total Parenteral Nutrition-Results From the Prospective PNLiver Trial [PDF]

, 2020
Liver abnormalities in intestinal failure (IF) patients receiving parenteral nutrition (PN) can progress undetected by standard laboratory tests to intestinal failure associated liver disease (IFALD). The aim of this longitudinal study is to evaluate the
Bednarsch, Jan, Blüthner, Elisabeth, Gerlach-Runge, Undine, Karber, Mirjam, Maasberg, Sebastian, Pape, Ulrich-Frank, Pascher, Andreas, Pevny, Sophie, Pratschke, Johann, Stockmann, Martin, Tacke, Frank   +10 more
core   +1 more source

Synergistic All‐in‐One Electroceutical Platform Utilizing a Plasma–Photodynamic Hybrid Approach for Enhanced Wound Healing

Advanced Functional Materials, EarlyView.
A flexible hybrid patch integrating a robust cold atmospheric plasma (CAP) system with a high‐power, ultrathin bio‐OLED was developed to enable synergistic wound healing. This multimodal therapy, combining plasma and photodynamic treatment, enhanced angiogenesis, cell proliferation, and collagen deposition, demonstrating superior in vivo efficacy and ...
Jun‐Yeop Song, Hyun Cheol Bang, Young Hyun Son, Dae‐In Ha, Eun‐Ju Hong, Sun‐Woo Lee, Jeongsook Kim, Doyeong Kim, Sang‐Min Park, Kyu Pil Lee, Hyo‐Jung Kwon, Jeong Hyun Kwon   +11 more
wiley   +1 more source

Chronic Hepatitis C: Acute Exacerbation and Alanine Aminotransferase Flare

Viruses, 2023
The hepatitis C virus (HCV) causes acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma, as well as extrahepatic manifestations such as malignant lymphoma. Currently, direct-acting antiviral agents (DAAs) against HCV infection can lead to
Tatsuo Kanda, Naoki Matsumoto, Tomotaka Ishii, Shuhei Arima, Shinji Shibuya, Masayuki Honda, Reina Sasaki-Tanaka, Ryota Masuzaki, Shini Kanezawa, Tsukasa Nishizawa, Yasuhiro Gon, Masahiro Ogawa, Hirofumi Kogure   +12 more
doaj   +1 more source

Yale - Alanine Aminotransferase v1 [PDF]

, 2019
Summary: Procedure used to measure the Alanine Amino activity in blood, plasma, and serum. Alanine Amino (ALT) activity is measured by the enzymatically coupled reactions of ALT (to form pyruvate from alanine and α-ketoglutarate) and Lactate dehydrogenase (conversion of pyruvate to lactate with oxdiation of NADH to NAD).
Gary Cline, John Stack
openaire   +1 more source