Results 51 to 60 of about 469,247 (341)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Protective Effect of Physalis Angulata Extract on Cisplatin-induced Hepatotoxicity in Rats

مجلة الانبار للعلوم البيطرية
The Physalis angulata extract has various therapeutic potentials and antioxidant properties, making it a promising candidate in supportive therapies to reduce the side effects of cytotoxic drugs. This study aimed the protective effects of P.
Atyaf Salih Hamood, , Ashwaq Talib Hameed, Nedhal Ibrahime Lateff,   +2 more
doaj   +1 more source

Association of the Aspartate Aminotransferase to Alanine Aminotransferase Ratio with BNP Level and Cardiovascular Mortality in the General Population: The Yamagata Study 10-Year Follow-Up

Disease Markers, 2016
Background. Early identification of high risk subjects for cardiovascular disease in health check-up is still unmet medical need. Cardiovascular disease is characterized by the superior increase in aspartate aminotransferase (AST) to alanine ...
Miyuki Yokoyama, Tetsu Watanabe, Y. Otaki, Hiroki Takahashi, T. Arimoto, T. Shishido, T. Miyamoto, T. Konta, Y. Shibata, M. Daimon, Y. Ueno, T. Kato, T. Kayama, I. Kubota   +13 more
semanticscholar   +1 more source

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Optimization of methods for aspartate aminotransferase and alanine aminotransferase.

Clinical Chemistry, 1978
Abstract Conditions for accurate measurement of catalytic activity of aspartate aminotransferase and alanine aminotransferase in human serum have been reinvestigated. The basic variables (kind of buffer, buffer concentration, pH, ion effects, and the influence of pyridoxal-5-phosphate) can now be considered optimized.
H U, Bergmeyer, P, Scheibe, A W, Wahlefeld   +2 more
openaire   +2 more sources

The aspartate aminotransferase-to-alanine aminotransferase ratio predicts all-cause and cardiovascular mortality in patients with type 2 diabetes

Medicine, 2016
An increased aspartate aminotransferase-to-alanine aminotransferase ratio (AAR) has been widely used as a marker of advanced hepatic fibrosis. Increased AAR was also shown to be significantly associated with the risk of developing cardiovascular (CV ...
G. Zoppini, V. Cacciatori, C. Negri, Vincenzo Stoico, G. Lippi, G. Targher, E. Bonora   +6 more
semanticscholar   +1 more source

Viral load and alanine aminotransferase correlate with serologic response in chronic hepatitis B patients treated with entecavir

, 2017
Background and Aim: Although entecavir has been shown to have good efficacy and low resistance for the treatment of chronic hepatitis B (CHB), factors associated with a favorable response remain unknown.
Wang, Chia-Chi;Tseng, Kuo-Chih;Peng, Cheng-Yuan;Hsieh, Tsai-Yuan;Lin, Chih-Lin;Su, Tung-Hung;Tseng, Tai-Chung;Hsu, Ching-Sheng;Lin, Hans Hsienhong;Kao, Jia-Horng, 高嘉宏   +1 more
core   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Postprandial Dysmetabolism and Non-Alcoholic Fatty Liver Disease in Relation to Type 2 Diabetes Mellitus and Cardiovascular Risk [PDF]

, 2007
Het aantal gevallen van “ouderdomssuikerziekte” (type 2 diabetes mellitus) neemt in de Westerse wereld snel toe als gevolg van veranderingen in leefstijl (verhoogde consumptie van vet- en energierijke voeding en verminderde lichaamsbeweging), en als ...
Schindhelm, R.K.
core  

Chronic Hepatitis C: Acute Exacerbation and Alanine Aminotransferase Flare

Viruses, 2023
The hepatitis C virus (HCV) causes acute and chronic hepatitis, cirrhosis, and hepatocellular carcinoma, as well as extrahepatic manifestations such as malignant lymphoma. Currently, direct-acting antiviral agents (DAAs) against HCV infection can lead to
Tatsuo Kanda, Naoki Matsumoto, Tomotaka Ishii, Shuhei Arima, Shinji Shibuya, Masayuki Honda, Reina Sasaki-Tanaka, Ryota Masuzaki, Shini Kanezawa, Tsukasa Nishizawa, Yasuhiro Gon, Masahiro Ogawa, Hirofumi Kogure   +12 more
doaj   +1 more source