Results 121 to 130 of about 196,626 (324)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Comparative Performance and Hemato-Biochemical Profile of Jinding Ducks in Different Production Systems of Bangladesh [PDF]

Pakistan Veterinary Journal, 2013
Jinding ducks are newly introduced to Bangladesh in commercial and household rearing. In order to assess production and hemato-biochemical status of Jinding ducks studies were conducted on household ducks of Chatkhil (August 2005-2006) and Sonagazi duck ...
S. A. Khan, M. Alauddin1, M. M. Hassan, S. K. M. A. Islam, M. B. Hossain, A. H. Shaikat, M. N. Islam, N. C. Debnath and M. A. Hoque*
doaj  

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

The Association between Dietary Nitrate Intake and Alanine Transaminase in Adolescent Girls

Journal of Environmental Health and Sustainable Development, 2022
Introduction: The effects of dietary nitrate on health are controversial. The current study aims to investigate the relationship between dietary intake of nitrate and liver enzymes among Iranian adolescent girls.
Zahra Darabi, Gordon A Ferns, Majid Ghayour-Mobarhan, Sayyed Saeid Khayyatzadeh   +3 more
doaj  

Alleviation of diabetic complications by ginsenoside Rg3-enriched red ginseng extract in western diet-fed LDL–/– mice

Journal of Ginseng Research, 2018
In this study, we precisely showed how the Rg3-enriched red ginseng extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL–/– mice.
Evelyn Saba, Seung-Hyung Kim, Sung-Dae Kim, Sang-Joon Park, Dongmi Kwak, Jun-Hwan Oh, Chae-Kyu Park, Man Hee Rhee   +7 more
doaj   +1 more source

Supplementary Figure 1 from Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase

, 2023
Ju Dong Yang, Jianliang Dai, Amit G. Singal, Purva Gopal, Benyam D. Addissie, Mindie H. Nguyen, Alex S. Befeler, K. Rajender Reddy, Myron Schwartz, Denise M. Harnois, Hiroyuki Yamada, Gregory J. Gores, Ziding Feng, Jorge A. Marrero, Lewis R. Roberts   +14 more
openalex   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Detection of D-glutamate Production from the Dual Function Enzyme, 4-amino-4-deoxychorismate Lyase/D-amino Acid Transaminase, in Mycobacterium smegmatis

Bio-Protocol, 2019
D-amino acid transaminase (D-AAT) is able to synthesize both D-glutamate and D-alanine, according to the following reaction: D-alanine + α-ketoglutarate ⇌ D-glutamate + pyruvate. These two D-amino acids are essential components of the peptidoglycan layer
Helen Opel-Reading, Roman Mortuza, Kurt Krause   +2 more
doaj   +1 more source

Sex influenced association of directly measured insulin sensitivity and serum transaminase levels: Why alanine aminotransferase only predicts cardiovascular risk in men? [PDF]

, 2015
Barbara Buday, Péter Pach, Botond Literáti-Nagy, Márta Vitai, Györgyi Kovács, Zsuzsa Vecsei, László Korányi, Csaba Lengyel   +7 more
openalex   +1 more source

Investigating Mitochondrial Viscosity in Ferroptosis‐Mediated Drug‐Induced Liver Injury using a Double‐Targeted Strategy

Advanced Science, EarlyView.
Utilizing a mitochondrial double‐targeted strategy, a novel near‐infrared fluorescent probe (FTZ‐2) is established for monitoring viscosity variations in ferroptosis‐mediated drug‐induced liver injury. In summary, this work provided a practical strategy for the early diagnosis and evaluation of liver injury.
Yongqing Zhou, Yan Wang, Bing Huang, Hosoowi Lee, Mei Yan, Juyoung Yoon   +5 more
wiley   +1 more source