Results 141 to 150 of about 196,626 (324)

Microenvironment Self‐Adaptive Nanoarmor to Address Adhesion‐ and Colonization‐Related Obstacles in Impaired Intestine Promote Bacteriotherapy Against Parkinson's Disease

Advanced Science, EarlyView.
A microenvironment self‐adaptive nanoarmor is developed to effectively address the adhesion‐ and colonization‐related challenges posed by multiple physiological and pathological characteristics in the intestine. L. plantarum@MPN@CS showed significant therapeutic potential in treating Parkinson's disease (PD), a model for extraintestinal disorders, as ...
Limeng Zhu, Yuyu Wu, Yingjie Chen, Xiyi Chen, Xingjie Zan, Yanlong Liu, Wujun Geng   +6 more
wiley   +1 more source

Development of prediction model for alanine transaminase elevations during the first 6 months of conventional synthetic DMARD treatment. [PDF]

Sci Rep, 2023
Kuusalo L, Venäläinen MS, Kirjala H, Saranpää S, Elo LL, Pirilä L.   +5 more
europepmc   +1 more source

Outcomes and safety of concomitant nevirapine and rifampicin treatment under programme conditions in Malawi. [PDF]

, 2010
SETTING: Thyolo District Hospital, rural Malawi. OBJECTIVES: To report on 1) clinical, immunological and virological outcomes and 2) safety among human immunodeficiency virus (HIV) infected patients with tuberculosis (TB) who received concurrent ...
Bauerfeind, A, Foncha, C, Harries, A D, Kwanjana, J, Manzi, M, Misinde, D, Moses, M, Mwagomba, B, Tayler-Smith, K, Zachariah, R   +9 more
core   +1 more source

Clinical features of hepatitis C-infected patients with persistently normal alanine transaminase levels in the southwestern United States [PDF]

, 1999
Mazen M. Jamal, Anurag Soni, Patrick G. Quinn, Donald E. Wheeler, Sanjeev Arora, David Johnston   +5 more
openalex   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

The prevalence of the elevation serum alanine amino transaminase at gorgan in Northern Iran [PDF]

, 2011
The elevation of serum alanine aminotranferase levels is associated most commonly with some forms of liver diseases. The aim of this study was to determine the prevalence of elevated serum alanine aminotransferase levels and the possible liver damages in
Mansourian, A.R., Saifi, A., Veghari, G.R.   +2 more
core  

Novel Vascularized Human Liver Organoids for Modeling Alcohol‐Induced Liver Injury and Developing Hepatoprotective Therapy

Advanced Science, EarlyView.
This study successfully engineered vascularized liver organoids (3HLOs) by co‐culturing human reprogrammed hepatocyte‐like cells (hrHLs) with human umbilical vein endothelial cells (HUVECs) and human umbilical mesenchymal stem cells (HUMSCs). Upon implantation, the 3HLOs established functional vascular anastomosis with the host circulation and ...
Kangdi Yang, Xiayan Chu, Xuerui Wang, Wenkun Zhang, Jinnuo Lu, Chuting Xu, Shoucheng Hu, Guoyu Pan, Chih‐Tsung Yang, Xiaohui Zhang, Shaojin Li, Zhaobin Guo, Hanyang Liu, Guangbo Ge   +13 more
wiley   +1 more source

A note on the prothrombin time abnormality in the patients with amebic liver abscess [PDF]

, 2006
Amebic liver abscess is reported worldwide and can present with a a wide spectrum of clinical manifetations. Similar to the other liver diseases, the prothrombin time abnormality can be seen in the patients with amebic liver abscess.
Suwansaksri, Jamsai, Suwansaksri, Nattakarn, Wiwaniikit, Viroj   +2 more
core   +1 more source

Correlation of Neutrophil Lymphocyte Ratio, Alanine Transaminase, and Aspartate Transaminase with Disease Severity in Mild-Moderate and Severe-Critical Coronavirus Disease-19 Patients

, 2023
Melvin F Gonga, Niluh Suwasanti, Nunung Nugroho, Bernadette Dian Novita, Dave Gerald Oenarta   +4 more
openalex   +2 more sources

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source