Results 171 to 180 of about 312,991 (333)

Effects of Various Drugs on Alcohol-induced Oxidative Stress in the Liver

open access: yesMolecules, 2008
The major aim of this work was to investigate how alcohol-induced oxidative stress in combined chemotherapy changes the metabolic function of the liver in experimental animals.
Svetlana Trivic   +4 more
doaj   +1 more source

Nucleotides as an Anti‐Aging Supplementation in Older Adults: A Randomized Controlled Trial (TALENTs study)

open access: yesAdvanced Science, EarlyView.
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang   +9 more
wiley   +1 more source

Temperature dependence of optical rotation study on parity-violating phase transition of D-, L-, and DL-alanine [PDF]

open access: yesarXiv, 2002
Chiral molecules are characterized by a specific optical rotation angle. An experimental method was presented to dissect the temperature dependence of the optical rotation angle with the molecular chirality of D-alanine, L-alanine and DL-alanine crystals. Salam hypothesis predicted that quantum mechanical cooperative and condensation phenomena may give
arxiv  

The association of alanine transaminase with aging, frailty, and mortality.

open access: yesThe journals of gerontology. Series A, Biological sciences and medical sciences, 2010
The relationships between blood tests of liver function and injury (alanine transaminase [ALT], gamma-glutamyl transferase, bilirubin, and albumin) with age, frailty, and survival were investigated in 1,673 community-dwelling men aged 70 years or older ...
D. L. Le Couteur   +8 more
semanticscholar   +1 more source

Communications Among Neurocytes in Parkinson's Disease Regulated by Differential Metabolism and Blood‐Brain Barrier Traversing of Chiral Gold Cluster‐MOF Integrated Nanoparticles

open access: yesAdvanced Science, EarlyView.
This study have loaded chiral gold nanoclusters onto the inner and outer surfaces of ZIF and uncovers the biodistribution, metabolic variances, and therapeutic mechanism of chiral nanoparticles, providing deep insights into the nanobiological effects of chiral anti‐inflammatory nanomedicines in PD therapy for future clinical transformation.
Junyang Chen   +7 more
wiley   +1 more source

Photoelectron Circular Dichroism of Aqueous-Phase Alanine [PDF]

open access: yesarXiv
Amino acids and other small chiral molecules play key roles in biochemistry. However, in order to understand how these molecules behave in vivo, it is necessary to study them under aqueous-phase conditions. Photoelectron circular dichroism (PECD) has emerged as an extremely sensitive probe of chiral molecules, but its suitability for application to ...
arxiv  

Comparative Effects of Ginseng Extract and Green Tea with Pomeol Bruler on C-Reactive Protein and Liver Enzymes of Rats Fed a High-Fat Diet

open access: yesمجله دانشگاه علوم پزشکی گرگان, 2022
Background and Objective: Many studies have been done on the effects of ginseng and green tea on inflammatory factors and liver enzymes, but no research has yet studied the comparative effects of ginseng and green tea extracts with Pomeol Breuler on C ...
Mandana Salehi   +3 more
doaj  

PRMT5 Inhibitor Synergizes with Chemotherapy to Induce Resembling Mismatch Repair Deficiency and Enhance Anti‐TIGIT Therapy in Microsatellite‐Stable Colorectal Cancer

open access: yesAdvanced Science, EarlyView.
Microsatellite‐stable (MSS) colorectal cancer (CRC) resists immunotherapy. PRMT5 inhibition enhances CPT‐11 sensitivity, inducing a PMS2‐deficient‐like state and cytosolic dsDNA release, which activates the cGAS‐STING pathway to promote anti‐tumor immunity. However, this combination therapy upregulates TIGIT expression on CD8+ T cells, and the addition
Jiang Zhu   +10 more
wiley   +1 more source

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