Sex influenced association of directly measured insulin sensitivity and serum transaminase levels: Why alanine aminotransferase only predicts cardiovascular risk in men? [PDF]
, 2015 Barbara Buday +7 more
openalex +1 more source
Advanced Science, EarlyView.Novel quaternary ammonium salt‐linked STING agonist ADC demonstrates high potency, stability, enhanced solubility, and reduced off‐target toxicity, potently activating the STING pathway in the tumor microenvironment through the synergistic action of the Fab and Fc regions of antibodies (activity switch‐on) while exhibiting ≈20 fold lower activity in ...
Yu Long +17 more
wiley +1 more source
Advanced Science, EarlyView.Mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) is developed as robust hydroxyl radical and oxygen nanogenerators for multimodal therapies. Their NIR‐II LSPR property also allowed MGSNs to be ideal phototheranostic agents. The chemodynamic and photothermal therapy efficiently induced the tumor cell apoptosis, enabling the MGNSs@Pt
Fei Cun +7 more
wiley +1 more source
Generating Minimum Free Energy Paths With Denoising Diffusion Probabilistic Models [PDF]
arXivA method combining denoising diffusion probabilistic models (DDPMs) with the string method is presented to generate minimum free energy paths between metastable states in molecular systems. It has been demonstrated in recent work that DDPMs at low noise levels can approximate the gradient of the potential of mean force, allowing efficient sampling of ...
arxiv
Effect of illness uncertainty on alanine transaminase levels and aspartate aminotransferase levels in patients with nonalcoholic fatty liver disease. [PDF]
Nagoya J Med Sci, 2022 Ozawa N +13 more
europepmc +1 more source
Peptide Bond Formation Between the Hetrosubunits of ω-Transaminase, Alanine Dehydrogenase, and Formate Dehydrogenase Through Subunit Splicing Promoted by Heterodimerization of Leucine Zipper Motifs [PDF]
, 2020 Rong Li, Yao Chen, Kun Du, Wei Feng
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Advanced Science, EarlyView.A self‐propelled nanomedicine delivery system forms DMCU nanoparticles in the bladder via in situ polymerization of dopamine hydrochloride, Mn2+, cGAMP, and urease. The urease‐driven propulsion enhances retention and drug delivery. These nanoparticles activate the STING pathway, stimulating dendritic cells and T cells to boost anti‐bladder cancer ...
Lei Peng +9 more
wiley +1 more source
Undiagnosed abnormal alanine transaminase levels in vulnerable populations: Impact of sex, race/ethnicity, and body mass. [PDF]
Obes Sci Pract, 2023 Kim RG, Khalili M.
europepmc +1 more source
Advanced Science, EarlyView.This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai +6 more
wiley +1 more source
Outcomes and safety of concomitant nevirapine and rifampicin treatment under programme conditions in Malawi. [PDF]
, 2010 SETTING: Thyolo District Hospital, rural Malawi. OBJECTIVES: To report on 1) clinical, immunological and virological outcomes and 2) safety among human immunodeficiency virus (HIV) infected patients with tuberculosis (TB) who received concurrent ...
Bauerfeind, A +9 more
core +1 more source