Results 241 to 250 of about 276,470 (294)

Platycodon grandiflorus–Derived Nanovesicles Sensitize Gastric Cancer to T Cell Killing via Ferroptosis‐Driven Membrane Mechanical Remodeling

Advanced Science, EarlyView.
Plant‐derived nanovesicles from Platycodon grandiflorus act as bioactive lipid delivery platforms that transport γ‐linolenic acid into gastric cancer cells. This lipid cargo promotes ferroptotic lipid peroxidation, remodels membrane mechanics, and increases tumor‐cell susceptibility to cytotoxic T‐cell attack.
Jian Wu, Ruijuan Zhang, Yixin Duan, Shuqi Huo, Xiang Zhang, Yibin Xing, Lingjing Ma, Tiran Jiang, Xingyu Chen, Qingmin Sun   +9 more
wiley   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

Advanced Science, EarlyView.
An engineered allosteric biosensor (UUU‐DZ‐tFNA) was developed, in which UDG specifically recognizes and activates a DNAzyme to achieve signal cycle amplification in a sequentially activatable mode. UUU‐DZ‐tFNA achieves in situ UDG detection across multiple biological levels and facilitates risk stratification and drug resistance monitoring of NB ...
Yaqing Lu, Yingyu Zhang, Xianwei Zhang, Mengxin Zhang, Fei Zhang, Jushan Sun, Yahui Yang, Kangbo Liu, Peng Wang, Shuying Luo, Wancun Zhang   +10 more
wiley   +1 more source

Comparative characterization of Aedes 3-hydroxykynurenine transaminase/alanine glyoxylate transaminase and Drosophila serine pyruvate aminotransferase [PDF]

FEBS Letters, 2002
This study describes the comparative analysis of two insect recombinant aminotransferases, Aedes aegypti 3-hydroxykynurenine (3-HK) transaminase/alanine glyoxylate aminotransferase (Ae-HKT/AGT) and Drosophila melanogaster serine pyruvate aminotransferase
Qian Han, Jianyong Li
exaly   +2 more sources

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Aspartate and Alanine Transaminases in Middle Ear Effusions

Acta Oto-Laryngologica, 1975
Mucous secretion from 24 ears with secretory otitis media was analysed for aspartate aminotransferase (Asp-AT) and from 18 ears for alanine aminotransferase (Ala-AT). The activity of both these enzymes in middle ear fluids was 40 times larger than in serum, the differences being statistically significant.
T, Palva, R, Nousiainen, V, Raunio
openaire   +2 more sources

Effects of the Antidepressant/Antipanic Drug Phenelzine on Alanine and Alanine Transaminase in Rat Brain

Cellular and Molecular Neurobiology, 2001
1. Phenelzine (PLZ) is an antidepressant with anxiolytic properties. Acute and chronic PLZ administration increase brain GABA levels, an effect due, at least in part, to an inhibition of the activity of the GABA metabolizing enzyme, GABA transaminase (GABA-T). 2.
V A, Tanay, M B, Parent, J T, Wong, T, Paslawski, I L, Martin, G B, Baker   +5 more
openaire   +2 more sources

Inhibition of Alanine Transaminase by the Hypoglycæmic Sulphonylurea Derivatives

Nature, 1957
BECAUSE of the recent interest in the mechanism of action of the two antidiabetic sulphonylurea derivatives, carbutamide (N1 sulphanilyl N2 n-butylcarbamide) and tolbutamide (N1 p-toluylsulphonyl N2 n-butylcarbamide), the effect of these compounds on the liver transaminase system was investigated, since inhibition of transamination reactions could lead
openaire   +2 more sources

Gamma-glutamyltransferase, alanine transaminase and aspartate transaminase levels and the diagnosis of gestational diabetes mellitus

Clinical Biochemistry, 2012
To evaluate gamma-glutamyltransferase (GGT), alanine transaminases (ALT) and aspartate transaminases (AST) levels and prevalent gestational diabetes mellitus (GDM).Random plasma glucose, GGT, ALT and AST and the 50-g glucose challenge test were done on antenatal women followed by diagnostic 3-point 75-g oral glucose tolerance test within two weeks. GDM
Tan, P.C., Aziz, A.Z., Ismail, Ikram Shah, Omar, S.Z.   +3 more
openaire   +3 more sources

[12] Glutamate-alanine transaminase

1985
Publisher Summary Glutamate–alanine transaminase is widely distributed. However, its activity in mammalian tissues is somewhat lower than that of glutamic–oxaloacetic transaminase (GOT). In the rat, highest activity is found in the liver with small amounts in skeletal muscle, heart, brain, and very little activity in kidney. The reaction catalyzed by
openaire   +1 more source