Results 251 to 260 of about 321,126 (349)

Nanoshield‐Assisted Viral Gene Therapy with Induction of Non‐Apoptotic Cell Death and Durable Antitumor Immunity

Advanced Science, EarlyView.
A novel hybrid gene delivery platform combines adeno‐associated virus (AAV)‐mediated receptor‐interacting kinase 3 (RIPK3) expression with manganese dioxide‐polyethyleneimine (MnO2−PEI) nanoshield to induce necroptosis, ferroptosis, and immunogenic cell death, effectively reprogramming the tumor microenvironment.
Soo‐Hwan Lee, Yunkyeong Cho, Seunghwan Bang, Daeun Sung, Jahyun Koo, Seoyoung Kim, Youngil Koh, Hojun Kim, Hyojin Lee   +8 more
wiley   +1 more source

Structural and Functional Insights into the Major Bacterial L-alanine Transaminases

, 2013
Póster presentado en el XXXVI Congreso de la Sociedad Española de Bioquímica y Biología Molecular SEBBM, celebrada del 3 al 6 de septiembre de 2013 en Madrid (España)
Fernández, Francisco J., Peña-Soler, Esther, López-Estepa, Miguel, Garces, Fernando, Richardson, Andrew J., Quintana, Juan F., Rudd, Kenneth E., Coll, Miquel, Vega, María Cristina   +8 more
openaire   +1 more source

Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway

Advanced Science, EarlyView.
Relapsed and refractory multiple myeloma remains a major clinical challenge. This study shows that FOXM1 contributes to resistance against BH3 mimetics in multiple myeloma cells. The FOXM1 inhibitor NB73 enhances the effectiveness of BH3 mimetics by reducing FOXM1 expression and suppressing the MYC pathway.
Zhi Wen, Yidan Wang, Kathryn C. Fox, Adam M. Bissonnette, Luke F. Moat, Terrie E. Kitchner, Kelsey Springstroh, Sung Hoon Kim, Dagna S. Sheerar, Patcharon Tanawattanacharoen, Chady A. Leon, Seth O. Fagbemi, John A. Katzenellenbogen, Scott J. Hebbring, Benita S. Katzenellenbogen, Siegfried Janz, Adedayo A. Onitilo   +16 more
wiley   +1 more source

Lutetium‐Based Nanoprobes for Radiosensitization with Immune Microenvironment Remodeling and NIR‐II Fluorescence Imaging‐Guided Surgery in Colorectal Cancer

Advanced Science, EarlyView.
Enhancing radiosensitization, modulating the tumor immune microenvironment, and ensuring complete resection are crucial for colorectal cancer (CRC) treatment. This study presents a multifunctional NIR‐II fluorescent nanoprobe, RVLu@ICG, which enhances radiosensitization, remodels the tumor immune microenvironment, and enables precise image‐guided ...
Yongying Dang, Xianzhi Liu, Zifan Zheng, Ao Wang, Ying Huang, Zhong Luo, Haina Tian, Siyaqi Li, Qiang Luo, Peiyuan Wang, Weiling He   +10 more
wiley   +1 more source

Clinical Significance of Pre-to-Postoperative Dynamics of Aspartate Transaminase/Alanine Transaminase Ratio in Predicting the Prognosis of Renal Cell Carcinoma after Surgical Treatment. [PDF]

Dis Markers, 2020
Kang M, Shin SJ, Sung HH, Jeon HG, Jeong BC, Jeon SS, Lee HM, Seo SI.   +7 more
europepmc   +1 more source

A Mesoporous Calcium Peroxide Nanocuboid with High Tumor Accumulation Across Biological Barriers for High Efficacy Tumor Therapy

Advanced Science, EarlyView.
The ferroheme (FH) and exceedingly small magnetic iron oxide nanoparticles (IO) loaded mesoporous calcium peroxide nanocuboid (MCPNC) with conjugation of hyaluronic acid (HA) possesses exceptional capability of tumor accumulation, and enhances therapeutic efficacy of tumors based on the mechanism of promoting a positive feedback loop of Fenton reaction
Qingdeng Fan, Min Wang, Jie Lin, Ya Huang, Jing Yang, Jiaoyang Zhu, Bin Ren, Li Sun, Zongheng Li, Aochi Liu, Wei Xiong, Zhenni Wei, Lin Huang, Chenggong Yan, Ge Wen, Zhao Chen, Xiaoyuan Chen, Zheyu Shen   +17 more
wiley   +1 more source

FIB‐3 index as a novel age‐independent predictor of liver fibrosis and prognosis in hepatocellular carcinoma patients undergoing hepatectomy

Annals of Gastroenterological Surgery, EarlyView.
Fibrosis‐3 index (FIB‐3) can stratify the risk of the survival and the recurrence‐free survival. The FIB‐3 index is a reliable, age‐independent tool for assessing liver fibrosis and prognosis in HCC patients post‐hepatectomy. Its use may improve clinical outcomes and support personalized treatment strategies. Abstract Background Liver fibrosis is a key
Yuki Imaoka, Masahiro Ohira, Tsuyoshi Kobayashi, Naruhiko Honmyo, Michinori Hamaoka, Takashi Onoe, Daisuke Takei, Koichi Oishi, Tomoyuki Abe, Toshihiro Nakayama, Miho Akabane, Kazunari Sasaki, Hideki Ohdan, Hiroshima Surgical study group of Clinical Oncology (HiSCO)   +13 more
wiley   +1 more source

Inhibition of the alanine–α-oxoglutaric acid transaminase of pig-heart muscle by cyclic hydrazides [PDF]

, 1957
Ray Hicks, J. Cymerman‐Craig
openalex   +1 more source

Significance of Neoadjuvant S‐1‐Based Chemotherapy for Older Patients With Locally Advanced Gastric Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Neoadjuvant chemotherapy (NAC) has been extensively developed for locally advanced gastric cancer (GC). In Asia, S‐1‐based regimens, such as docetaxel, oxaliplatin, and S‐1 (DOS) and S‐1 and oxaliplatin (SOX), are expected to become the standard of care.
Kota Kawabata, Takuro Saito, Yukinori Kurokawa, Kazuyoshi Yamamoto, Tsuyoshi Takahashi, Koji Tanaka, Tomoki Makino, Kiyokazu Nakajima, Hidetoshi Eguchi, Yuichiro Doki   +9 more
wiley   +1 more source

Association Between Distance to the Transplant Center and Survival Following Living Donor Liver Transplantation

Annals of Gastroenterological Surgery, EarlyView.
This study investigated the impacts of distance to transplant center on posttransplant survival following LDLT. Patients living further away from the transplant center had worse graft and patient survival rates than those of patients living closer, probably due to less frequency of follow‐up visits, and living > 40 miles from our treatment center was ...
Hajime Matsushima, Akihiko Soyama, Takanobu Hara, Ayaka Kinoshita, Takashi Hamada, Kazushige Migita, Ayaka Satoh, Hajime Imamura, Tomohiko Adachi, Susumu Eguchi   +9 more
wiley   +1 more source