Results 41 to 50 of about 175,083 (295)

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Effect of hyperbaric oxygenation on the regeneration of the liver after partial hepatectomy in rats

Brazilian Journal of Medical and Biological Research, 2004
The aim of the present study was to assess the influence of hyperbaric oxygenation (HBO) on rat liver regeneration before and after partial hepatectomy.
T.T. Kurir, A. Markotic, V. Katalinic, D. Bozanic, V. Cikes, T. Zemunik, D. Modun, J. Rincic, V. Boraska, B. Bota, I. Salamunic, S. Radic   +11 more
doaj   +1 more source

Probing alanine transaminase catalysis with hyperpolarized 13CD3-pyruvate [PDF]

Journal of Magnetic Resonance, 2013
Hyperpolarized metabolites offer a tremendous sensitivity advantage (>10(4) fold) when measuring flux and enzyme activity in living tissues by magnetic resonance methods. These sensitivity gains can also be applied to mechanistic studies that impose time and metabolite concentration limitations.
A W, Barb, S K, Hekmatyar, J N, Glushka, J H, Prestegard   +3 more
openaire   +2 more sources

Localization of L-alanine: 4,5-dioxovalerate transaminase in the matrix of the rat kidney mitochondria

, 1991
The bulk of the enzyme L-alanine: 4,5-dioxovalerate transaminase, which catalyses the transamination reaction between L-alanine and 4,5-dioxovalerate to synthesize d-aminolevulinic acid was predominantly recovered in the mitochondrial matrix.
Tyagi, Rakesh K., Datta, K.
core   +1 more source

beta-Chloro-L-alanine inhibition of the Escherichia coli alanine-valine transaminase [PDF]

Journal of Bacteriology, 1985
beta-Chloro-L-alanine, an amino acid analog which inhibits a number of enzymes, reversibly inhibited the Escherichia coli K-12 alanine-valine transaminase, transaminase C. This inhibition, along with the inhibition of transaminase B, accounted for the isoleucine-plus-valine requirement of E. coli in the presence of beta-chloro-L-alanine.
W A, Whalen, M D, Wang, C M, Berg
openaire   +2 more sources

Multimodal Soft Surgical Robots Enabled by Eco‐Degradable, Sterilizable Polymers and Transient Electronics

Advanced Functional Materials, EarlyView.
A compostable PGS soft surgical robot with interchangeable modules integrates transient Mo tactile and Si thermal sensors for dual feedback. The device preserves its function after clinical‐grade sterilization, demonstrates stable actuation and cardiac tissue grasping with real‐time in vivo pulsatile monitoring, and biodegrades post‐use with soil‐safe, 
Minseong Chae, Kyung‐Sub Kim, Gyeong‐Seok Hwang, Jun‐Seok Shim, Sung‐Woo Kim, Yong‐Wu Kim, Jieun Han, Jae‐Young Bae, Jae‐Hwan Lee, Minjung Chae, Jooik Jeon, Joo‐Hyeon Park, You‐Jung Park, Ju‐Yong Lee, Sung‐Geun Choi, Min‐Ha Oh, Yong‐Joong Shin, Young‐In Ryu, Ji‐Woo Gu, Seong‐Yu Choi, Jeong‐Yun Sun, Jung Keun Hyun, Myoung‐Ryul Ok, Sang Yup Kim, Edyta Wyszkowska, Ju‐Young Kim, Kang‐Sik Lee, Seung‐Kyun Kang   +27 more
wiley   +1 more source

Changes in Alanine transaminase levels in response to statins: Sri Lankan experience in patient with type 2 Diabetes mellitus with Dyslipidemia

Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2018
Background:Statins form the pharmacologic cornerstone of the primary and secondary prevention of atherosclerotic cardiovascular disease. While statins are well-tolerated by most people, the most common adverse effect is the asymptomatic elevation of ...
C.N. Antonypillai, W.C.K. Jayawardena, I.G. Samarakkody, S. Dahanayake, L. Monaragala, D.L.N. Wijerathne, T.L. Dassanayake   +6 more
doaj   +1 more source

De Ritis ratio (aspartate transaminase/alanine transaminase) as a significant prognostic factor with upper urinary tract carcinoma who underwent radical nephroureterectomy and adjuvant chemotherapy

, 2019
We investigate the correlation between preoperative De Ritis ratio (aspartate transaminase [AST]/alanine transaminase [ALT]) and postoperative clinical outcome in patients with upper urinary tract carcinoma (UTUC) who underwent radical nephroureterectomy
Ji Hyeong Yu (7049456), Luck Hee Sung (7049450), Dae Yeon Cho (7049449), Jae Yong Chung (7049454), Hyeong Dong Yuk (5539460)   +4 more
core   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Immunomodulatory and hepatoprotective properties of Solanum torvum (Turkey berry)

Sahel Medical Journal, 2018
Background: Solanum torvum, commonly known as turkey berry, is used majorly as a medicinal plant, especially in Africa. Thus, this research investigated the effects of aqueous leaf extract of S.
Silvanus Olu Innih, Kingsley Chukwunonso Agu, Gerald Ikechi Eze   +2 more
doaj   +1 more source