Results 41 to 50 of about 276,470 (294)

beta-Chloro-L-alanine inhibition of the Escherichia coli alanine-valine transaminase [PDF]

Journal of Bacteriology, 1985
beta-Chloro-L-alanine, an amino acid analog which inhibits a number of enzymes, reversibly inhibited the Escherichia coli K-12 alanine-valine transaminase, transaminase C. This inhibition, along with the inhibition of transaminase B, accounted for the isoleucine-plus-valine requirement of E. coli in the presence of beta-chloro-L-alanine.
W A, Whalen, M D, Wang, C M, Berg
openaire   +2 more sources

The role of Kupffer cells in carbon tetrachloride intoxication in mice. [PDF]

, 2012
Carbon tetrachloride (CCl(4))-induced acute hepatitis is assumed to involve two phases. The initial phase, initiated within 2 h after CCl(4) administration, involves the generation of reactive oxygen species.
10130, Ueno, Satoko, Fukui, Kiyoshi, Ichi, Ikuyo, 10129, Fukuda, Mana, 10128, Kojo, Shosuke, Kobayashi, Keiko, Sakai, Takashi, 10131, 10125, 10124, Kiso, Kaori, 10127, 10126   +15 more
core  

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Excess generation of endogenous heme inhibits L-alanine: 4,5-dioxovalerate transaminase in rat liver mitochondria

, 1986
In the present study, we examined the possibility that the excess heme generation within mitochondria may provide a local concentration, sufficient to inhibit the activity of L-alanine: 4,5-dioxovalerate transaminase, the enzyme proposed for an alternate
Shanker, J., Datta, K.
core   +1 more source

Liver function tests may be useful tools for advanced cancer patient care: A preliminary single-center result

Kaohsiung Journal of Medical Sciences, 2014
Accurate prognostication in advanced cancer may facilitate better palliative care. An objective marker may be more applicable and appropriate than a subjective evaluation by physicians. The aim of this study was to evaluate liver function tests as useful
Hui-Ju Tsai, Ming-Yen Hsieh, Yi-Chun Tsai, Zi-Yun Liu, Hui-Ya Hsieh, Chiou-Mei Lee, Ching-Hsin Chien, Yu-Wen Chiu, Hung-Yi Chuang, Chia-Tsuan Huang   +9 more
doaj   +1 more source

Probing alanine transaminase catalysis with hyperpolarized 13CD3-pyruvate [PDF]

Journal of Magnetic Resonance, 2013
Hyperpolarized metabolites offer a tremendous sensitivity advantage (>10(4) fold) when measuring flux and enzyme activity in living tissues by magnetic resonance methods. These sensitivity gains can also be applied to mechanistic studies that impose time and metabolite concentration limitations.
A W, Barb, S K, Hekmatyar, J N, Glushka, J H, Prestegard   +3 more
openaire   +2 more sources

Impact of Six‐Month Monitoring Compared to Three‐Month Monitoring of Laboratories During Methotrexate Therapy

Arthritis Care &Research, EarlyView.
Objective To evaluate whether extending the American College of Rheumatology–recommended monitoring interval for complete blood count and liver function tests in patients receiving methotrexate (MTX) affects timely detection of medication‐related toxicity.
Spencer Simko, Ray Zhang, Sohini Mukherjee, Puneet Bajaj, Bonnie L. Bermas   +4 more
wiley   +1 more source

Effect of hyperbaric oxygenation on the regeneration of the liver after partial hepatectomy in rats

Brazilian Journal of Medical and Biological Research, 2004
The aim of the present study was to assess the influence of hyperbaric oxygenation (HBO) on rat liver regeneration before and after partial hepatectomy.
T.T. Kurir, A. Markotic, V. Katalinic, D. Bozanic, V. Cikes, T. Zemunik, D. Modun, J. Rincic, V. Boraska, B. Bota, I. Salamunic, S. Radic   +11 more
doaj   +1 more source

The Importance of De Ritis Ratio in Patients with Bladder Cancer

Bagcilar Medical Bulletin, 2020
Objective:Numerous studies prove the relationship between serum aspartate transaminase/alanine transaminase (AST/ALT) ratio (De Ritis Ratio) and cancer cases.
Kasım Ertaş, Recep Eryılmaz, Rahmi Aslan, Murat Demir, Kerem Taken   +4 more
doaj   +1 more source

Induction of L-alanine: 4,5-dioxovalerate transaminase by phenylhydrazine is associated with depletion of heme level

, 1986
The hemin regulation of L-alanine:4,5-dioxovalerate transaminase, the enzyme proposed for an alternate route of δ-aminolevulinic acid (ALA) biosynthesis in mammalian system was studied in different conditions: phenylhydrazine induced anemia, polycythemia
Singh, N. K., Datta, K., Chhabra, R.
core   +1 more source