Results 51 to 60 of about 276,470 (294)

Elevated Liver Enzymes Is Not an Impediment to Allopurinol Dose Escalation: An Observational Cohort Study

Arthritis Care &Research, EarlyView.
Objective Routine liver enzyme monitoring is advocated for while on allopurinol, but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzyme levels in patients with gout commenced on allopurinol. Methods One hundred and fifty patients with gout and normal baseline serum aminotransferases initiated on ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

Biochemical study of some metabolic indicators of fish Mastacembelus mastacembelus (Banks & Solander, 1794) and its parasite tapeworm Senga mastacembeli

Fisheries and Aquatic Sciences
This study is the first global attempt to evaluate the influence of the parasitic tapeworm Senga mastacembeli on its fish host, Mastacembelus mastacembelus, using tissue biomolecules to bridge the informational void regarding this fish.
Mohammad Hussein Mikael, Najwa Mahfoodh Ahmed, Bushra Hasan AL-Niaeemi   +2 more
doaj   +1 more source

Changes in Alanine transaminase levels in response to statins: Sri Lankan experience in patient with type 2 Diabetes mellitus with Dyslipidemia

Sri Lanka Journal of Diabetes Endocrinology and Metabolism, 2018
Background:Statins form the pharmacologic cornerstone of the primary and secondary prevention of atherosclerotic cardiovascular disease. While statins are well-tolerated by most people, the most common adverse effect is the asymptomatic elevation of ...
C.N. Antonypillai, W.C.K. Jayawardena, I.G. Samarakkody, S. Dahanayake, L. Monaragala, D.L.N. Wijerathne, T.L. Dassanayake   +6 more
doaj   +1 more source

Multifunctional Neutrophil Nanovesicles Induce Remodeling of Tumor Immune Microenvironment and Synergistic Multimodal Tumor Therapy

Advanced Functional Materials, EarlyView.
Schematic illustration of the engineered RN@FDT for multimodal tumor therapy. a) Fabrication of FD&DOX/TFA‐loaded RGD‐NNV (RN@FDT) and the light‐triggered disassemble of RN@FDT. b) After internalized by tumor cells, RN@FDT are disintegrated under NIR‐II laser irradiation to boost PTT and induce cell apoptosis.
Jiahui Zhang, Cheng Ji, Xin‐Jian Fang, Yu Qian, Jiayuan Shi, Wenhui Liu, Baiyuan Fan, Yuan Zhong, Jiayi Wang, Dan Yu, Maoye Wang, Min Fu, Xiaoxin Zhang, Runbi Ji, Hélder A. Santos, Hongbo Zhang, Xu Zhang   +16 more
wiley   +1 more source

Presence of raised alanine transaminase (ALT) levels and any fibrosis according to the severity of fatty liver assessed by ultrasound.

, 2022
Presence of raised alanine transaminase (ALT) levels and any fibrosis according to the severity of fatty liver assessed by ultrasound.
Nikhil Tandon (126558), Ariba Peerzada (12072472), Shalimar (10643465), Lakshmy Ramakrishnan (249738), Bhanvi Grover (12072475), Devasenathipathy Kandasamy (12072466), Garima Rautela (12072469), Ritvik Amarchand (6112175), Roopa Shivashankar (344936), Md Asadullah (12072463), Raju Sharma (12072478), Anand Krishnan (238402), Baibaswata Nayak (292413), Dimple Kondal (3486635), Dorairaj Prabhakaran (102287)   +14 more
core   +1 more source

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

Relation of transaminase levels with severity of Hepatitis A in children.

Pakistan Armed Forces Medical Journal
Objectives: To determine the sensitivity, specificity and diagnostic accuracy of serum alanine transaminase and serum aspartate transaminase in detecting the presence of severe Hepatitis A in children. Study Design: Cross-sectional validation study.
Rehan Mehmood, Farooq Ikram, Babar Ali, Sammara Sarwar, Zohaib Akhtar, Bilal Munawar   +5 more
doaj   +1 more source

Limited mid palmar versus extended incision in surgical treatment of carpal tunnel syndrome: Clinical analysis

Zanco Journal of Medical Sciences, 2020
Background and objective: Patients on blood transfusion may develop complications related to iron overload and the effects of chelating agents (drugs), which adversely affect the liver in thalassemia, which is a genetic blood disorder of hemoglobin ...
Jagar Omar Doski, Reber Saeed Sindy, Farhad Taher Hamzani, Hishyar Osman Omar   +3 more
doaj   +1 more source

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Immunomodulatory and hepatoprotective properties of Solanum torvum (Turkey berry)

Sahel Medical Journal, 2018
Background: Solanum torvum, commonly known as turkey berry, is used majorly as a medicinal plant, especially in Africa. Thus, this research investigated the effects of aqueous leaf extract of S.
Silvanus Olu Innih, Kingsley Chukwunonso Agu, Gerald Ikechi Eze   +2 more
doaj   +1 more source